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Potent anti-influenza H7 human monoclonal antibody induces separation of hemagglutinin receptor-binding head domains.
Turner HL, Pallesen J, Lang S, Bangaru S, Urata S, Li S, Cottrell CA, Bowman CA, Crowe JE, Wilson IA, Ward AB
(2019) PLoS Biol 17: e3000139
MeSH Terms: Amino Acid Sequence, Animals, Antibodies, Neutralizing, Antibody Specificity, Baculoviridae, Binding Sites, Cloning, Molecular, Cryoelectron Microscopy, Gene Expression, Hemagglutinin Glycoproteins, Influenza Virus, Hydrogen Bonding, Immunoglobulin Fab Fragments, Influenza A virus, Molecular Docking Simulation, Protein Binding, Protein Conformation, alpha-Helical, Protein Conformation, beta-Strand, Protein Interaction Domains and Motifs, Recombinant Proteins, Sequence Alignment, Sequence Homology, Amino Acid, Sf9 Cells, Spodoptera
Added March 31, 2019
0 Communities
1 Members
0 Resources
23 MeSH Terms
An alternative N-terminal fold of the intestine-specific annexin A13a induces dimerization and regulates membrane-binding.
McCulloch KM, Yamakawa I, Shifrin DA, McConnell RE, Foegeding NJ, Singh PK, Mao S, Tyska MJ, Iverson TM
(2019) J Biol Chem 294: 3454-3463
MeSH Terms: Animals, Annexins, Cell Membrane, Epithelial Cells, Humans, Hydrogen-Ion Concentration, Intestinal Mucosa, Intestines, Liposomes, Mice, Models, Molecular, Organ Specificity, Protein Binding, Protein Conformation, alpha-Helical, Protein Multimerization, Protein Structure, Quaternary, Protein Transport
Added April 1, 2019
0 Communities
1 Members
0 Resources
17 MeSH Terms
Structure-function analyses of the ion channel TRPC3 reveal that its cytoplasmic domain allosterically modulates channel gating.
Sierra-Valdez F, Azumaya CM, Romero LO, Nakagawa T, Cordero-Morales JF
(2018) J Biol Chem 293: 16102-16114
MeSH Terms: Allosteric Regulation, Ankyrin Repeat, HEK293 Cells, Humans, Ion Channel Gating, Mutation, Protein Conformation, alpha-Helical, Protein Domains, TRPC Cation Channels
Added April 10, 2019
0 Communities
1 Members
0 Resources
9 MeSH Terms
De novo designed transmembrane peptides activating the α5β1 integrin.
Mravic M, Hu H, Lu Z, Bennett JS, Sanders CR, Orr AW, DeGrado WF
(2018) Protein Eng Des Sel 31: 181-190
MeSH Terms: Amino Acid Sequence, Cell Membrane, Computer-Aided Design, Drug Design, Humans, Integrin alpha5beta1, Micelles, Peptides, Protein Conformation, alpha-Helical, Protein Domains
Added November 21, 2018
0 Communities
1 Members
0 Resources
10 MeSH Terms
Structure and Function of the Transmembrane Domain of NsaS, an Antibiotic Sensing Histidine Kinase in Staphylococcus aureus.
Bhate MP, Lemmin T, Kuenze G, Mensa B, Ganguly S, Peters JM, Schmidt N, Pelton JG, Gross CA, Meiler J, DeGrado WF
(2018) J Am Chem Soc 140: 7471-7485
MeSH Terms: Anti-Bacterial Agents, Bacitracin, Bacterial Proteins, Gene Knockout Techniques, Histidine Kinase, Hydrophobic and Hydrophilic Interactions, Magnetic Resonance Spectroscopy, Membrane Proteins, Microbial Sensitivity Tests, Molecular Dynamics Simulation, Nisin, Protein Conformation, alpha-Helical, Protein Domains, Staphylococcus aureus
Added March 21, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
Bexarotene Binds to the Amyloid Precursor Protein Transmembrane Domain, Alters Its α-Helical Conformation, and Inhibits γ-Secretase Nonselectively in Liposomes.
Kamp F, Scheidt HA, Winkler E, Basset G, Heinel H, Hutchison JM, LaPointe LM, Sanders CR, Steiner H, Huster D
(2018) ACS Chem Neurosci 9: 1702-1713
MeSH Terms: Amyloid Precursor Protein Secretases, Amyloid beta-Protein Precursor, Bexarotene, Cholesterol, HEK293 Cells, Humans, Liposomes, Molecular Structure, Neuroprotective Agents, Phosphatidylcholines, Protein Conformation, alpha-Helical, Protein Domains, Receptor, Notch1, Static Electricity
Added November 21, 2018
0 Communities
1 Members
0 Resources
14 MeSH Terms
The triple helix of collagens - an ancient protein structure that enabled animal multicellularity and tissue evolution.
Fidler AL, Boudko SP, Rokas A, Hudson BG
(2018) J Cell Sci 131:
MeSH Terms: Animals, Cellular Microenvironment, Collagen Type IV, Evolution, Molecular, Extracellular Matrix, Protein Conformation, alpha-Helical
Added April 16, 2018
0 Communities
1 Members
0 Resources
6 MeSH Terms
Integrated Structural Biology for α-Helical Membrane Protein Structure Determination.
Xia Y, Fischer AW, Teixeira P, Weiner B, Meiler J
(2018) Structure 26: 657-666.e2
MeSH Terms: Algorithms, Binding Sites, Electron Spin Resonance Spectroscopy, Humans, Membrane Proteins, Microscopy, Electron, Models, Molecular, Monte Carlo Method, Nuclear Magnetic Resonance, Biomolecular, Protein Binding, Protein Conformation, alpha-Helical, Protein Folding, Protein Interaction Domains and Motifs, Rhodopsin, Thermodynamics
Added March 17, 2018
0 Communities
1 Members
0 Resources
15 MeSH Terms
Selective killing of with pH-responsive helix-coil conformation transitionable antimicrobial polypeptides.
Xiong M, Bao Y, Xu X, Wang H, Han Z, Wang Z, Liu Y, Huang S, Song Z, Chen J, Peek RM, Yin L, Chen LF, Cheng J
(2017) Proc Natl Acad Sci U S A 114: 12675-12680
MeSH Terms: Amines, Animals, Anti-Bacterial Agents, Antimicrobial Cationic Peptides, Disease Models, Animal, Female, Glutamic Acid, Helicobacter Infections, Helicobacter pylori, Hydrogen-Ion Concentration, Mice, Mice, Inbred C57BL, Mice, Inbred ICR, Organ Specificity, Protein Conformation, alpha-Helical, Static Electricity, Stomach
Added March 14, 2018
0 Communities
1 Members
0 Resources
17 MeSH Terms
Prostaglandin E glyceryl ester is an endogenous agonist of the nucleotide receptor P2Y.
Brüser A, Zimmermann A, Crews BC, Sliwoski G, Meiler J, König GM, Kostenis E, Lede V, Marnett LJ, Schöneberg T
(2017) Sci Rep 7: 2380
MeSH Terms: Animals, Binding Sites, Cell Line, Tumor, Cyclooxygenase 2, Dinoprostone, HEK293 Cells, High-Throughput Nucleotide Sequencing, High-Throughput Screening Assays, Humans, Kinetics, Ligands, Mice, Molecular Docking Simulation, Protein Binding, Protein Conformation, alpha-Helical, Protein Conformation, beta-Strand, Protein Interaction Domains and Motifs, Purinergic Agonists, RAW 264.7 Cells, Receptors, Purinergic P2, Substrate Specificity, Thermodynamics, Transcriptome
Added March 17, 2018
0 Communities
2 Members
0 Resources
23 MeSH Terms