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Galantamine protects against synaptic, axonal, and vision deficits in experimental neurotrauma.
Naguib S, Bernardo-Colón A, Cencer C, Gandra N, Rex TS
(2020) Neurobiol Dis 134: 104695
MeSH Terms: Acetylcholinesterase, Administration, Oral, Animals, Axons, Cholinesterase Inhibitors, Evoked Potentials, Visual, Galantamine, Male, Mice, Inbred C57BL, Neuroprotective Agents, Optic Nerve, Optic Nerve Injuries, Retina, Synapses
Added March 3, 2020
0 Communities
1 Members
0 Resources
14 MeSH Terms
BIO 300, a Nanosuspension of Genistein, Mitigates Radiation-Induced Erectile Dysfunction and Sensitizes Human Prostate Cancer Xenografts to Radiation Therapy.
Jackson IL, Pavlovic R, Alexander AA, Connors CQ, Newman D, Mahmood J, Eley J, Harvey AJ, Kaytor MD, Vujaskovic Z
(2019) Int J Radiat Oncol Biol Phys 105: 400-409
MeSH Terms: Animals, Blood Pressure, Disease Models, Animal, Drugs, Investigational, Erectile Dysfunction, Fibrosis, Genistein, Male, Mice, Mice, Nude, Nanoparticles, Penile Erection, Penis, Prostate, Radiation Injuries, Experimental, Radiation-Protective Agents, Random Allocation, Rats, Rats, Sprague-Dawley, Regional Blood Flow, Suspensions, Transplantation, Heterologous
Added March 30, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
Cancer therapy-induced cardiovascular toxicity: old/new problems and old drugs.
Beyer AM, Bonini MG, Moslehi J
(2019) Am J Physiol Heart Circ Physiol 317: H164-H167
MeSH Terms: Animals, Anthracyclines, Antibiotics, Antineoplastic, Cardiotoxicity, Cardiovascular System, Heart Diseases, Humans, Protective Agents
Added November 12, 2019
0 Communities
1 Members
0 Resources
8 MeSH Terms
Metformin Improves Learning and Memory in the SAMP8 Mouse Model of Alzheimer's Disease.
Farr SA, Roesler E, Niehoff ML, Roby DA, McKee A, Morley JE
(2019) J Alzheimers Dis 68: 1699-1710
MeSH Terms: Alzheimer Disease, Animals, Disease Models, Animal, Maze Learning, Memory, Metformin, Mice, Neuroprotective Agents, Treatment Outcome
Added April 30, 2019
0 Communities
1 Members
0 Resources
9 MeSH Terms
Pharmacologic ATF6 activation confers global protection in widespread disease models by reprograming cellular proteostasis.
Blackwood EA, Azizi K, Thuerauf DJ, Paxman RJ, Plate L, Kelly JW, Wiseman RL, Glembotski CC
(2019) Nat Commun 10: 187
MeSH Terms: Activating Transcription Factor 6, Animals, Animals, Newborn, Cells, Cultured, Cerebral Infarction, Disease Models, Animal, Endoplasmic Reticulum, Female, Heart Ventricles, Humans, Kidney, Kidney Diseases, Male, Mice, Mice, Inbred C57BL, Mice, Knockout, Myocardial Infarction, Myocytes, Cardiac, Primary Cell Culture, Protective Agents, Proteostasis, Rats, Reperfusion Injury, Treatment Outcome, Unfolded Protein Response
Added March 3, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
Bexarotene Binds to the Amyloid Precursor Protein Transmembrane Domain, Alters Its α-Helical Conformation, and Inhibits γ-Secretase Nonselectively in Liposomes.
Kamp F, Scheidt HA, Winkler E, Basset G, Heinel H, Hutchison JM, LaPointe LM, Sanders CR, Steiner H, Huster D
(2018) ACS Chem Neurosci 9: 1702-1713
MeSH Terms: Amyloid Precursor Protein Secretases, Amyloid beta-Protein Precursor, Bexarotene, Cholesterol, HEK293 Cells, Humans, Liposomes, Molecular Structure, Neuroprotective Agents, Phosphatidylcholines, Protein Conformation, alpha-Helical, Protein Domains, Receptor, Notch1, Static Electricity
Added November 21, 2018
0 Communities
1 Members
0 Resources
14 MeSH Terms
"Manganese-induced neurotoxicity: a review of its behavioral consequences and neuroprotective strategies".
Peres TV, Schettinger MR, Chen P, Carvalho F, Avila DS, Bowman AB, Aschner M
(2016) BMC Pharmacol Toxicol 17: 57
MeSH Terms: Animals, Brain, Cognition Disorders, Food, Humans, Manganese, Manganese Poisoning, Motor Skills Disorders, Neuroprotective Agents, Parkinson Disease
Added April 26, 2017
0 Communities
1 Members
0 Resources
10 MeSH Terms
Beyond Acetylcholinesterase Inhibitors: Novel Cholinergic Treatments for Alzheimer's Disease.
Kamkwalala AR, Newhouse PA
(2017) Curr Alzheimer Res 14: 377-392
MeSH Terms: Alzheimer Disease, Animals, Cholinergic Agents, Humans, Neuroprotective Agents, Nootropic Agents
Added March 3, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
Meclizine Preconditioning Protects the Kidney Against Ischemia-Reperfusion Injury.
Kishi S, Campanholle G, Gohil VM, Perocchi F, Brooks CR, Morizane R, Sabbisetti V, Ichimura T, Mootha VK, Bonventre JV
(2015) EBioMedicine 2: 1090-101
MeSH Terms: Acute Kidney Injury, Adenosine Triphosphate, Animals, Cell Respiration, Cytochromes c, Deoxyglucose, Disease Models, Animal, Epithelial Cells, Ethanolamines, Galactose, Glycolysis, Humans, Inflammation, Ischemic Preconditioning, Kidney, Kidney Tubules, L-Lactate Dehydrogenase, LLC-PK1 Cells, Male, Meclizine, Mice, Inbred C57BL, Mitochondria, Protective Agents, Reperfusion Injury, Sodium Cyanide, Swine, Up-Regulation
Added September 12, 2016
1 Communities
1 Members
0 Resources
27 MeSH Terms
Bilirubin prevents acute DSS-induced colitis by inhibiting leukocyte infiltration and suppressing upregulation of inducible nitric oxide synthase.
Zucker SD, Vogel ME, Kindel TL, Smith DL, Idelman G, Avissar U, Kakarlapudi G, Masnovi ME
(2015) Am J Physiol Gastrointest Liver Physiol 309: G841-54
MeSH Terms: Animals, Bilirubin, Cell Movement, Colitis, Colon, Cytotoxins, Dextran Sulfate, Interleukin-5, Intestinal Mucosa, Leukocytes, Male, Mice, Mice, Inbred C57BL, Nitric Oxide Synthase Type II, Protective Agents, Up-Regulation, Vascular Cell Adhesion Molecule-1
Added April 27, 2017
0 Communities
1 Members
0 Resources
17 MeSH Terms