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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 21

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Prospective Study of Cardiac Events During Proteasome Inhibitor Therapy for Relapsed Multiple Myeloma.
Cornell RF, Ky B, Weiss BM, Dahm CN, Gupta DK, Du L, Carver JR, Cohen AD, Engelhardt BG, Garfall AL, Goodman SA, Harrell SL, Kassim AA, Jadhav T, Jagasia M, Moslehi J, O'Quinn R, Savona MR, Slosky D, Smith A, Stadtmauer EA, Vogl DT, Waxman A, Lenihan D
(2019) J Clin Oncol 37: 1946-1955
MeSH Terms: Adult, Aged, Aged, 80 and over, Bortezomib, Cardiovascular Diseases, Disease-Free Survival, Electrocardiography, Female, Heart Diseases, Humans, Kaplan-Meier Estimate, Male, Middle Aged, Molecular Targeted Therapy, Multiple Myeloma, Natriuretic Peptide, Brain, Neoplasm Recurrence, Local, Oligopeptides, Prospective Studies, Proteasome Inhibitors, Risk Factors, Time-to-Treatment, Treatment Outcome, Troponin I, Troponin T
Added November 12, 2019
0 Communities
1 Members
0 Resources
25 MeSH Terms
Mechanisms of KCNQ1 channel dysfunction in long QT syndrome involving voltage sensor domain mutations.
Huang H, Kuenze G, Smith JA, Taylor KC, Duran AM, Hadziselimovic A, Meiler J, Vanoye CG, George AL, Sanders CR
(2018) Sci Adv 4: eaar2631
MeSH Terms: Cell Membrane, HEK293 Cells, Humans, KCNQ1 Potassium Channel, Leupeptins, Long QT Syndrome, Loss of Function Mutation, Magnetic Resonance Spectroscopy, Mutant Proteins, Mutation, Proteasome Endopeptidase Complex, Proteasome Inhibitors, Protein Domains, Protein Folding, Protein Structure, Secondary, Proteolysis
Added March 14, 2018
0 Communities
3 Members
0 Resources
16 MeSH Terms
Recurrent cardiotoxicity potentiated by the interaction of proteasome inhibitor and immunomodulatory therapy for the treatment of multiple myeloma.
Fradley MG, Groarke JD, Laubach J, Alsina M, Lenihan DJ, Cornell RF, Maglio M, Shain KH, Richardson PG, Moslehi J
(2018) Br J Haematol 180: 271-275
MeSH Terms: Adult, Antineoplastic Agents, Immunological, Antineoplastic Combined Chemotherapy Protocols, Cardiotoxicity, Electrocardiography, Female, Heart Diseases, Humans, Magnetic Resonance Imaging, Multiple Myeloma, Proteasome Inhibitors
Added December 2, 2017
0 Communities
1 Members
0 Resources
11 MeSH Terms
A retrospective analysis of 3954 patients in phase 2/3 trials of bortezomib for the treatment of multiple myeloma: towards providing a benchmark for the cardiac safety profile of proteasome inhibition in multiple myeloma.
Laubach JP, Moslehi JJ, Francis SA, San Miguel JF, Sonneveld P, Orlowski RZ, Moreau P, RosiƱol L, Faber EA, Voorhees P, Mateos MV, Marquez L, Feng H, Desai A, van de Velde H, Elliott J, Shi H, Dow E, Jobanputra N, Esseltine DL, Niculescu L, Anderson KC, Lonial S, Richardson PG
(2017) Br J Haematol 178: 547-560
MeSH Terms: Antineoplastic Agents, Benchmarking, Bortezomib, Cardiovascular Diseases, Clinical Trials, Phase II as Topic, Clinical Trials, Phase III as Topic, Dyspnea, Heart Failure, Humans, Multiple Myeloma, Proteasome Inhibitors, Retrospective Studies, Risk Factors
Added December 2, 2017
0 Communities
1 Members
0 Resources
13 MeSH Terms
Bortezomib augments lymphocyte stimulatory cytokine signaling in the tumor microenvironment to sustain CD8+T cell antitumor function.
Pellom ST, Dudimah DF, Thounaojam MC, Uzhachenko RV, Singhal A, Richmond A, Shanker A
(2017) Oncotarget 8: 8604-8621
MeSH Terms: Adenocarcinoma, Animals, Antineoplastic Agents, Bortezomib, Breast Neoplasms, CD8-Positive T-Lymphocytes, Cell Line, Tumor, Cytokines, Female, Fibrosarcoma, Kidney Neoplasms, Lung Neoplasms, Lymphocytes, Tumor-Infiltrating, Mice, Inbred BALB C, Mice, Transgenic, Phosphatidylinositol 3-Kinase, Proteasome Endopeptidase Complex, Proteasome Inhibitors, Proto-Oncogene Proteins c-akt, Receptors, Cytokine, STAT5 Transcription Factor, Signal Transduction, Tumor Escape, Tumor Microenvironment
Added March 14, 2017
2 Communities
1 Members
0 Resources
24 MeSH Terms
Cardiovascular and Thrombotic Complications of Novel Multiple Myeloma Therapies: A Review.
Li W, Garcia D, Cornell RF, Gailani D, Laubach J, Maglio ME, Richardson PG, Moslehi J
(2017) JAMA Oncol 3: 980-988
MeSH Terms: Antineoplastic Agents, Cardiovascular Diseases, Humans, Immunologic Factors, Lenalidomide, Multiple Myeloma, Proteasome Inhibitors, Risk Factors, Thalidomide, Thromboembolism, Thrombosis
Added March 26, 2017
0 Communities
1 Members
0 Resources
11 MeSH Terms
Specificity of Protein Covalent Modification by the Electrophilic Proteasome Inhibitor Carfilzomib in Human Cells.
Federspiel JD, Codreanu SG, Goyal S, Albertolle ME, Lowe E, Teague J, Wong H, Guengerich FP, Liebler DC
(2016) Mol Cell Proteomics 15: 3233-3242
MeSH Terms: Cell Line, Tumor, Cholestanetriol 26-Monooxygenase, Click Chemistry, Glutathione Transferase, Hep G2 Cells, Humans, Molecular Structure, Oligopeptides, Proteasome Inhibitors, Tandem Mass Spectrometry
Added March 14, 2018
0 Communities
1 Members
0 Resources
10 MeSH Terms
Local application of a proteasome inhibitor enhances fracture healing in rats.
Yoshii T, Nyman JS, Yuasa M, Esparza JM, Okawa A, Gutierrez GE
(2015) J Orthop Res 33: 1197-204
MeSH Terms: Animals, Biomechanical Phenomena, Bone Morphogenetic Protein 2, Cell Differentiation, Femoral Fractures, Fracture Healing, Male, Osteogenesis, Proteasome Inhibitors, Rats, Rats, Sprague-Dawley, Stem Cells, Tomography, X-Ray Computed
Added March 16, 2015
1 Communities
1 Members
0 Resources
13 MeSH Terms
The challenge of cross-trial comparisons using limited data.
Laubach JP, Faber EA, Voorhees P, Moslehi J, Varga C, Niculescu L, Anderson KC, Richardson PG
(2014) Haematologica 99: e145-6
MeSH Terms: Female, Humans, Male, Multiple Myeloma, Oligopeptides, Proteasome Inhibitors
Added March 4, 2015
0 Communities
1 Members
0 Resources
6 MeSH Terms
Combined chemical and genetic approach to inhibit proteolysis by the proteasome.
Collins GA, Gomez TA, Deshaies RJ, Tansey WP
(2010) Yeast 27: 965-74
MeSH Terms: ATP-Binding Cassette Transporters, Biological Transport, Enzyme Inhibitors, Gene Deletion, Leupeptins, Peptide Hydrolases, Proteasome Inhibitors, Saccharomyces cerevisiae, Saccharomyces cerevisiae Proteins
Added March 10, 2014
0 Communities
1 Members
0 Resources
9 MeSH Terms