Androgen receptor inhibitor treatments: Cardiovascular adverse events and comorbidity considerations in patients with non-metastatic prostate cancer.
Morgans AK, Shore N, Cope D, McNatty A, Moslehi J, Gomella L, Sartor O
(2021) Urol Oncol 39
: 52-62MeSH Terms: Androgen Antagonists, Cardiovascular Diseases, Drug Interactions, Humans, Male, Neoplasm Metastasis, Prostatic Neoplasms, Castration-Resistant, Risk Assessment, Risk FactorsAdded September 29, 2020
9 MeSH Terms
Combination immunotherapy and radiotherapy causes an abscopal treatment response in a mouse model of castration resistant prostate cancer.
Dudzinski SO, Cameron BD, Wang J, Rathmell JC, Giorgio TD, Kirschner AN
(2019) J Immunother Cancer 7
: 218MeSH Terms: Animals, Disease Models, Animal, Humans, Immunotherapy, Male, Mice, Prostatic Neoplasms, Castration-ResistantAdded March 3, 2020
7 MeSH Terms
Radiosensitization by enzalutamide for human prostate cancer is mediated through the DNA damage repair pathway.
Sekhar KR, Wang J, Freeman ML, Kirschner AN
(2019) PLoS One 14
: e0214670MeSH Terms: Aged, Animals, Cell Line, Tumor, Cell Proliferation, DNA Damage, DNA Repair, Drug Resistance, Neoplasm, Humans, Male, Mice, Mice, Nude, Mice, Transgenic, Phenylthiohydantoin, Prostatic Neoplasms, Prostatic Neoplasms, Castration-Resistant, Radiation Tolerance, Radiation-Sensitizing Agents, Signal Transduction, Xenograft Model Antitumor AssaysAdded April 2, 2019
19 MeSH Terms
Activation of GRP/GRP-R signaling contributes to castration-resistant prostate cancer progression.
Qiao J, Grabowska MM, Forestier-Roman IS, Mirosevich J, Case TC, Chung DH, Cates JM, Matusik RJ, Manning HC, Jin R
(2016) Oncotarget 7
: 61955-61969MeSH Terms: Adenocarcinoma, Androgen Antagonists, Androgens, Antineoplastic Agents, Cell Line, Tumor, Disease Progression, Gastrin-Releasing Peptide, Gene Expression Regulation, Neoplastic, Genetic Variation, Humans, Male, Prostatic Neoplasms, Castration-Resistant, RNA Splicing, Receptors, Androgen, Receptors, Bombesin, Signal Transduction, Transcription, GeneticAdded April 6, 2017
17 MeSH Terms
NF-κB and androgen receptor variant 7 induce expression of SRD5A isoforms and confer 5ARI resistance.
Austin DC, Strand DW, Love HL, Franco OE, Grabowska MM, Miller NL, Hameed O, Clark PE, Matusik RJ, Jin RJ, Hayward SW
(2016) Prostate 76
: 1004-18MeSH Terms: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase, 5-alpha Reductase Inhibitors, Animals, Apoptosis, Drug Resistance, Gene Expression, Gene Knockdown Techniques, Humans, Isoenzymes, Lower Urinary Tract Symptoms, Male, Membrane Proteins, Mice, Mice, Nude, NF-kappa B, Orchiectomy, Prostate, Prostatic Hyperplasia, Prostatic Neoplasms, Castration-Resistant, Receptors, Androgen, Testosterone, Treatment Failure, Up-RegulationAdded April 18, 2017
23 MeSH Terms
Enzalutamide Versus Bicalutamide in Castration-Resistant Prostate Cancer: The STRIVE Trial.
Penson DF, Armstrong AJ, Concepcion R, Agarwal N, Olsson C, Karsh L, Dunshee C, Wang F, Wu K, Krivoshik A, Phung D, Higano CS
(2016) J Clin Oncol 34
: 2098-106MeSH Terms: Adult, Aged, Androgen Antagonists, Anilides, Antineoplastic Agents, Double-Blind Method, Humans, Male, Middle Aged, Nitriles, Phenylthiohydantoin, Prostate-Specific Antigen, Prostatic Neoplasms, Castration-Resistant, Tosyl CompoundsAdded February 4, 2016
14 MeSH Terms
PIM kinase inhibitor AZD1208 for treatment of MYC-driven prostate cancer.
Kirschner AN, Wang J, van der Meer R, Anderson PD, Franco-Coronel OE, Kushner MH, Everett JH, Hameed O, Keeton EK, Ahdesmaki M, Grosskurth SE, Huszar D, Abdulkadir SA
(2015) J Natl Cancer Inst 107
: MeSH Terms: Administration, Oral, Allografts, Animals, Antineoplastic Agents, Apoptosis, Biphenyl Compounds, Cell Hypoxia, Cell Proliferation, Down-Regulation, Gene Expression Regulation, Enzymologic, Gene Expression Regulation, Neoplastic, Genes, myc, Humans, Male, Mice, Prostatic Neoplasms, Prostatic Neoplasms, Castration-Resistant, Protein Kinase Inhibitors, Proto-Oncogene Proteins c-pim-1, Thiazolidines, Tumor Suppressor Protein p53, Xenograft Model Antitumor AssaysAdded January 21, 2015
22 MeSH Terms
Inhibition of NF-kappa B signaling restores responsiveness of castrate-resistant prostate cancer cells to anti-androgen treatment by decreasing androgen receptor-variant expression.
Jin R, Yamashita H, Yu X, Wang J, Franco OE, Wang Y, Hayward SW, Matusik RJ
(2015) Oncogene 34
: 3700-10MeSH Terms: Androgen Antagonists, Anilides, Antineoplastic Agents, Antineoplastic Combined Chemotherapy Protocols, Boronic Acids, Bortezomib, Cell Line, Tumor, Humans, Male, NF-kappa B, Nitriles, Prostatic Neoplasms, Castration-Resistant, Pyrazines, Receptors, Androgen, Signal Transduction, Tosyl Compounds, Xenograft Model Antitumor AssaysAdded January 20, 2015
17 MeSH Terms
NF-κB gene signature predicts prostate cancer progression.
Jin R, Yi Y, Yull FE, Blackwell TS, Clark PE, Koyama T, Smith JA, Matusik RJ
(2014) Cancer Res 74
: 2763-72MeSH Terms: Animals, Carcinogenesis, Cell Line, Tumor, Disease Models, Animal, Disease Progression, Gene Expression Profiling, Gene Regulatory Networks, Humans, I-kappa B Proteins, Male, Mice, Mice, Transgenic, NF-KappaB Inhibitor alpha, NF-kappa B, Neoplasm Metastasis, Prostatic Neoplasms, Prostatic Neoplasms, Castration-Resistant, Signal TransductionAdded May 27, 2014
18 MeSH Terms
Nrf1 and Nrf2 transcription factors regulate androgen receptor transactivation in prostate cancer cells.
Schultz MA, Hagan SS, Datta A, Zhang Y, Freeman ML, Sikka SC, Abdel-Mageed AB, Mondal D
(2014) PLoS One 9
: e87204MeSH Terms: Analysis of Variance, Cell Line, Tumor, Chromatin Immunoprecipitation, DNA Primers, Dihydrotestosterone, Electrophoretic Mobility Shift Assay, Humans, Immunoblotting, Luciferases, Male, NF-E2-Related Factor 2, Nuclear Respiratory Factor 1, Prostatic Neoplasms, Castration-Resistant, Real-Time Polymerase Chain Reaction, Receptors, Androgen, Transcriptional ActivationAdded March 13, 2014
16 MeSH Terms