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Results: 1 to 10 of 38

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Dendritic Cell Amiloride-Sensitive Channels Mediate Sodium-Induced Inflammation and Hypertension.
Barbaro NR, Foss JD, Kryshtal DO, Tsyba N, Kumaresan S, Xiao L, Mernaugh RL, Itani HA, Loperena R, Chen W, Dikalov S, Titze JM, Knollmann BC, Harrison DG, Kirabo A
(2017) Cell Rep 21: 1009-1020
MeSH Terms: Amiloride, Animals, Cells, Cultured, Cytokines, Dendritic Cells, Epithelial Sodium Channel Blockers, Epithelial Sodium Channels, Hypertension, Inflammation, Male, Mice, Mice, Inbred C57BL, NADPH Oxidases, Oxidative Stress, Prostaglandins E, Protein Kinase C, Sodium, Sodium-Hydrogen Exchanger 1, Superoxides
Added December 27, 2017
0 Communities
2 Members
0 Resources
19 MeSH Terms
Isolevuglandins as a gauge of lipid peroxidation in human tumors.
Yan HP, Roberts LJ, Davies SS, Pohlmann P, Parl FF, Estes S, Maeng J, Parker B, Mernaugh R
(2017) Free Radic Biol Med 106: 62-68
MeSH Terms: Antibodies, Carcinogenesis, Cell Line, Tumor, Cell Proliferation, Free Radicals, Humans, Lipid Peroxidation, Neoplasms, Oxidative Stress, Phospholipids, Prostaglandin-Endoperoxide Synthases, Prostaglandins E, Reactive Oxygen Species
Added July 17, 2019
1 Communities
1 Members
0 Resources
MeSH Terms
Reactive gamma-ketoaldehydes as novel activators of hepatic stellate cells in vitro.
Longato L, Andreola F, Davies SS, Roberts JL, Fusai G, Pinzani M, Moore K, Rombouts K
(2017) Free Radic Biol Med 102: 162-173
MeSH Terms: Aldehydes, Apoptosis, Autophagy, Cell Proliferation, Hepatic Stellate Cells, Humans, Lipid Peroxidation, Liver, Liver Cirrhosis, NF-kappa B, Oxidative Stress, Prostaglandins E, Reactive Oxygen Species
Added July 17, 2019
1 Communities
1 Members
0 Resources
MeSH Terms
Isolevuglandin-type lipid aldehydes induce the inflammatory response of macrophages by modifying phosphatidylethanolamines and activating the receptor for advanced glycation endproducts.
Guo L, Chen Z, Amarnath V, Yancey PG, Van Lenten BJ, Savage JR, Fazio S, Linton MF, Davies SS
(2015) Antioxid Redox Signal 22: 1633-45
MeSH Terms: Aldehydes, Animals, Humans, Inflammation, Lipids, Macrophages, Male, Mice, Inbred C57BL, Mice, Knockout, NF-kappa B, Phosphatidylethanolamines, Prostaglandins E, Pyrrolidines, Receptor for Advanced Glycation End Products
Added October 8, 2015
2 Communities
2 Members
0 Resources
14 MeSH Terms
Levuglandin forms adducts with histone h4 in a cyclooxygenase-2-dependent manner, altering its interaction with DNA.
Carrier EJ, Zagol-Ikapitte I, Amarnath V, Boutaud O, Oates JA
(2014) Biochemistry 53: 2436-41
MeSH Terms: Chromatography, Liquid, Cyclooxygenase 2, DNA, Histones, Mass Spectrometry, Prostaglandin D2, Prostaglandins E, Solubility
Added January 22, 2015
0 Communities
2 Members
0 Resources
8 MeSH Terms
Isoketals form cytotoxic phosphatidylethanolamine adducts in cells.
Sullivan CB, Matafonova E, Roberts LJ, Amarnath V, Davies SS
(2010) J Lipid Res 51: 999-1009
MeSH Terms: Animals, Cell Line, Cell Survival, Cytotoxins, Endothelial Cells, Humans, Phosphatidylethanolamines, Phospholipase D, Prostaglandins E, Streptomyces
Added June 1, 2013
1 Communities
3 Members
0 Resources
10 MeSH Terms
Characterization of covalent adducts of nucleosides and DNA formed by reaction with levuglandin.
Carrier EJ, Amarnath V, Oates JA, Boutaud O
(2009) Biochemistry 48: 10775-81
MeSH Terms: Chromatography, Liquid, DNA, Nucleosides, Prostaglandins E, Spectrometry, Mass, Electrospray Ionization
Added March 20, 2014
1 Communities
3 Members
0 Resources
5 MeSH Terms
Levels of prostaglandin E metabolite and leukotriene E(4) are increased in the urine of smokers: evidence that celecoxib shunts arachidonic acid into the 5-lipoxygenase pathway.
Duffield-Lillico AJ, Boyle JO, Zhou XK, Ghosh A, Butala GS, Subbaramaiah K, Newman RA, Morrow JD, Milne GL, Dannenberg AJ
(2009) Cancer Prev Res (Phila) 2: 322-9
MeSH Terms: Arachidonate 5-Lipoxygenase, Arachidonic Acid, Celecoxib, Cyclooxygenase 2, Cyclooxygenase 2 Inhibitors, Female, Humans, Leukotriene E4, Male, Middle Aged, Pneumonia, Prostaglandins E, Pyrazoles, Signal Transduction, Smoking, Sulfonamides
Added March 26, 2014
1 Communities
1 Members
0 Resources
16 MeSH Terms
Low concentrations of reactive gamma-ketoaldehydes prime thromboxane-dependent human platelet aggregation via p38-MAPK activation.
Bernoud-Hubac N, Alam DA, Lefils J, Davies SS, Amarnath V, Guichardant M, Roberts LJ, Lagarde M
(2009) Biochim Biophys Acta 1791: 307-13
MeSH Terms: Blood Platelets, Blotting, Western, Collagen, Cytosol, Humans, Isoprostanes, MAP Kinase Kinase Kinases, Phospholipases A2, Phosphorylation, Platelet Activation, Platelet Aggregation, Prostaglandins E, Proto-Oncogene Proteins, Pyridoxamine, Thromboxane B2, Vitamin B Complex
Added June 1, 2013
1 Communities
1 Members
0 Resources
16 MeSH Terms
Measurement of chronic oxidative and inflammatory stress by quantification of isoketal/levuglandin gamma-ketoaldehyde protein adducts using liquid chromatography tandem mass spectrometry.
Davies SS, Amarnath V, Brame CJ, Boutaud O, Roberts LJ
(2007) Nat Protoc 2: 2079-91
MeSH Terms: Aldehydes, Chromatography, High Pressure Liquid, Inflammation, Isoprostanes, Lipid Peroxidation, Oxidative Stress, Prostaglandins E, Proteins, Tandem Mass Spectrometry
Added December 10, 2013
1 Communities
3 Members
0 Resources
9 MeSH Terms