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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 12

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Neurotoxic lipid peroxidation species formed by ischemic stroke increase injury.
Zeiger SL, Musiek ES, Zanoni G, Vidari G, Morrow JD, Milne GJ, McLaughlin B
(2009) Free Radic Biol Med 47: 1422-31
MeSH Terms: Animals, Calcium, Cells, Cultured, Cytochromes c, Dose-Response Relationship, Drug, Humans, Lipid Peroxidation, Mass Spectrometry, Mitochondria, Neurons, Prostaglandins A, Rats, Rats, Sprague-Dawley, Reactive Oxygen Species, Reperfusion Injury, Stroke, Time Factors
Added March 26, 2014
1 Communities
2 Members
0 Resources
17 MeSH Terms
Cyclopentenone isoprostanes are novel bioactive products of lipid oxidation which enhance neurodegeneration.
Musiek ES, Breeding RS, Milne GL, Zanoni G, Morrow JD, McLaughlin B
(2006) J Neurochem 97: 1301-13
MeSH Terms: Adaptor Proteins, Signal Transducing, Animals, Arachidonate 12-Lipoxygenase, Cells, Cultured, Cyclopentanes, Dose-Response Relationship, Drug, Excitatory Amino Acid Agonists, Glutamic Acid, Glutathione, Isoprostanes, Lipid Peroxidation, Mitogen-Activated Protein Kinase 3, Models, Neurological, Molecular Structure, Nerve Degeneration, Neurons, Oxidative Stress, Phosphorylation, Prostaglandins A, Rats, Rats, Sprague-Dawley, Reactive Oxygen Species, Shc Signaling Adaptor Proteins, Src Homology 2 Domain-Containing, Transforming Protein 1
Added March 26, 2014
0 Communities
2 Members
0 Resources
24 MeSH Terms
The cyclopentenone (A2/J2) isoprostanes--unique, highly reactive products of arachidonate peroxidation.
Milne GL, Musiek ES, Morrow JD
(2005) Antioxid Redox Signal 7: 210-20
MeSH Terms: Animals, Arachidonic Acid, Carbon, Chromatography, Gas, Cyclopentanes, Docosahexaenoic Acids, Eicosanoids, Fatty Acids, Gas Chromatography-Mass Spectrometry, Humans, Isoprostanes, Leukotrienes, Lipids, Models, Chemical, Oxidation-Reduction, Peroxides, Prostaglandin-Endoperoxide Synthases, Prostaglandins A, Time Factors, alpha-Linolenic Acid
Added March 26, 2014
0 Communities
1 Members
0 Resources
20 MeSH Terms
The cyclopentenone product of lipid peroxidation, 15-A2t-isoprostane, is efficiently metabolized by HepG2 cells via conjugation with glutathione.
Milne GL, Zanoni G, Porta A, Sasi S, Vidari G, Musiek ES, Freeman ML, Morrow JD
(2004) Chem Res Toxicol 17: 17-25
MeSH Terms: Cyclopentanes, Cysteine, Glutathione, Humans, Lipid Peroxidation, Prostaglandins A, Spectrometry, Mass, Electrospray Ionization, Time Factors, Tritium, Tumor Cells, Cultured
Added March 5, 2014
0 Communities
2 Members
0 Resources
10 MeSH Terms
The cyclopentenone product of lipid peroxidation, 15-A(2t)-isoprostane (8-isoprostaglandin A(2)), is efficiently conjugated with glutathione by human and rat glutathione transferase A4-4.
Hubatsch I, Mannervik B, Gao L, Roberts LJ, Chen Y, Morrow JD
(2002) Chem Res Toxicol 15: 1114-8
MeSH Terms: Animals, Cyclopentanes, Glutathione, Glutathione Transferase, Humans, Kinetics, Lipid Peroxidation, Prostaglandins A, Rats, Recombinant Proteins, Spectrometry, Mass, Electrospray Ionization
Added December 10, 2013
0 Communities
1 Members
0 Resources
11 MeSH Terms
The origin of 15R-prostaglandins in the Caribbean coral Plexaura homomalla: molecular cloning and expression of a novel cyclooxygenase.
Valmsen K, Järving I, Boeglin WE, Varvas K, Koljak R, Pehk T, Brash AR, Samel N
(2001) Proc Natl Acad Sci U S A 98: 7700-5
MeSH Terms: Amino Acid Sequence, Animals, Cloning, Molecular, Cnidaria, Dinoprostone, Molecular Sequence Data, Prostaglandin-Endoperoxide Synthases, Prostaglandins, Prostaglandins A, Sequence Alignment, Stereoisomerism
Added December 10, 2013
0 Communities
1 Members
0 Resources
11 MeSH Terms
Formation of reactive cyclopentenone compounds in vivo as products of the isoprostane pathway.
Chen Y, Morrow JD, Roberts LJ
(1999) J Biol Chem 274: 10863-8
MeSH Terms: Animals, Arachidonic Acid, Cyclopentanes, Humans, Liver, Mass Spectrometry, Oxidation-Reduction, Prostaglandin D2, Prostaglandins A, Rats
Added December 10, 2013
0 Communities
1 Members
0 Resources
10 MeSH Terms
Evidence for the formation of a novel cyclopentenone isoprostane, 15-A2t-isoprostane (8-iso-prostaglandin A2) in vivo.
Chen Y, Zackert WE, Roberts LJ, Morrow JD
(1999) Biochim Biophys Acta 1436: 550-6
MeSH Terms: Animals, Carbon Tetrachloride, Chromatography, High Pressure Liquid, Gas Chromatography-Mass Spectrometry, Liver, Oxidative Stress, Prostaglandins A, Rats, Rats, Sprague-Dawley, Tritium
Added December 10, 2013
0 Communities
1 Members
0 Resources
10 MeSH Terms
Prostaglandin A2 blocks the activation of G1 phase cyclin-dependent kinase without altering mitogen-activated protein kinase stimulation.
Hitomi M, Shu J, Strom D, Hiebert SW, Harter ML, Stacey DW
(1996) J Biol Chem 271: 9376-83
MeSH Terms: 3T3 Cells, Animals, Calcium-Calmodulin-Dependent Protein Kinases, Cell Cycle, Cell Transformation, Neoplastic, Cyclin-Dependent Kinases, Enzyme Activation, G1 Phase, G2 Phase, Kinetics, Mice, Microinjections, Mitosis, Oncogene Proteins v-raf, Oncogenes, Phosphorylation, Prostaglandins A, Retinoblastoma Protein, Retroviridae Proteins, Oncogenic, Time Factors, ras Proteins
Added June 10, 2010
1 Communities
1 Members
0 Resources
21 MeSH Terms
Prostacyclin production during pregnancy: comparison of production during normal pregnancy and pregnancy complicated by hypertension.
Goodman RP, Killam AP, Brash AR, Branch RA
(1982) Am J Obstet Gynecol 142: 817-22
MeSH Terms: Adult, Creatinine, Epoprostenol, Female, Gas Chromatography-Mass Spectrometry, Humans, Hypertension, Pregnancy, Pregnancy Complications, Cardiovascular, Pregnancy Trimester, Second, Pregnancy Trimester, Third, Prostaglandins, Prostaglandins A, Synthetic
Added December 10, 2013
0 Communities
1 Members
0 Resources
13 MeSH Terms