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Differential cyclooxygenase expression levels and survival associations in type I and type II ovarian tumors.
Beeghly-Fadiel A, Wilson AJ, Keene S, El Ramahi M, Xu S, Marnett LJ, Fadare O, Crispens MA, Khabele D
(2018) J Ovarian Res 11: 17
MeSH Terms: Aged, Biomarkers, Tumor, Cyclooxygenase 1, Cyclooxygenase 2, Female, Gene Expression Regulation, Neoplastic, Humans, Immunohistochemistry, Kaplan-Meier Estimate, Middle Aged, Neoplasm Grading, Neoplasm Staging, Ovarian Neoplasms, Prognosis, Proportional Hazards Models, Prostaglandin-Endoperoxide Synthases
Added March 21, 2018
0 Communities
2 Members
0 Resources
16 MeSH Terms
Dual cyclooxygenase-fatty acid amide hydrolase inhibitor exploits novel binding interactions in the cyclooxygenase active site.
Goodman MC, Xu S, Rouzer CA, Banerjee S, Ghebreselasie K, Migliore M, Piomelli D, Marnett LJ
(2018) J Biol Chem 293: 3028-3038
MeSH Terms: Amidohydrolases, Catalytic Domain, Cyclooxygenase Inhibitors, Isoenzymes, Phenylcarbamates, Phenylpropionates, Prostaglandin-Endoperoxide Synthases, Protein Binding, Stereoisomerism, Substrate Specificity
Added April 22, 2018
0 Communities
1 Members
0 Resources
10 MeSH Terms
Isolevuglandins as a gauge of lipid peroxidation in human tumors.
Yan HP, Roberts LJ, Davies SS, Pohlmann P, Parl FF, Estes S, Maeng J, Parker B, Mernaugh R
(2017) Free Radic Biol Med 106: 62-68
MeSH Terms: Antibodies, Carcinogenesis, Cell Line, Tumor, Cell Proliferation, Free Radicals, Humans, Lipid Peroxidation, Neoplasms, Oxidative Stress, Phospholipids, Prostaglandin-Endoperoxide Synthases, Prostaglandins E, Reactive Oxygen Species
Added July 17, 2019
1 Communities
1 Members
0 Resources
MeSH Terms
13-Methylarachidonic acid is a positive allosteric modulator of endocannabinoid oxygenation by cyclooxygenase.
Kudalkar SN, Nikas SP, Kingsley PJ, Xu S, Galligan JJ, Rouzer CA, Banerjee S, Ji L, Eno MR, Makriyannis A, Marnett LJ
(2015) J Biol Chem 290: 7897-909
MeSH Terms: Allosteric Regulation, Arachidonic Acids, Endocannabinoids, Kinetics, Oxygen, Prostaglandin-Endoperoxide Synthases
Added February 22, 2016
0 Communities
3 Members
0 Resources
6 MeSH Terms
The role of prostaglandins in allergic lung inflammation and asthma.
Claar D, Hartert TV, Peebles RS
(2015) Expert Rev Respir Med 9: 55-72
MeSH Terms: Animals, Asthma, Cyclooxygenase Inhibitors, Disease Models, Animal, Humans, Lung, Pneumonia, Prostaglandin-Endoperoxide Synthases, Prostaglandins, Receptors, Prostaglandin, Respiratory Hypersensitivity, Signal Transduction
Added January 20, 2015
0 Communities
2 Members
0 Resources
12 MeSH Terms
Cyclooxygenase inhibition abrogates aeroallergen-induced immune tolerance by suppressing prostaglandin I2 receptor signaling.
Zhou W, Goleniewska K, Zhang J, Dulek DE, Toki S, Lotz MT, Newcomb DC, Boswell MG, Polosukhin VV, Milne GL, Wu P, Moore ML, FitzGerald GA, Peebles RS
(2014) J Allergy Clin Immunol 134: 698-705.e5
MeSH Terms: Air Pollution, Allergens, Animals, Enzyme Inhibitors, Epoprostenol, Humans, Hypersensitivity, Immune Tolerance, Indomethacin, Mice, Mice, 129 Strain, Mice, Inbred BALB C, Mice, Inbred C57BL, Mice, Knockout, Ovalbumin, Prostaglandin-Endoperoxide Synthases, Receptors, Epoprostenol, Signal Transduction
Added January 20, 2015
0 Communities
1 Members
0 Resources
18 MeSH Terms
Neurosensory perception of environmental cues modulates sperm motility critical for fertilization.
McKnight K, Hoang HD, Prasain JK, Brown N, Vibbert J, Hollister KA, Moore R, Ragains JR, Reese J, Miller MA
(2014) Science 344: 754-7
MeSH Terms: Animals, Caenorhabditis elegans, Caenorhabditis elegans Proteins, Environmental Exposure, Female, Fertilization, Male, Neurons, Afferent, Neurosecretory Systems, Oocytes, Ovum, Perception, Pheromones, Prostaglandin-Endoperoxide Synthases, Prostaglandins, Sperm Motility, Spermatozoa, Transforming Growth Factor beta
Added May 19, 2014
0 Communities
1 Members
0 Resources
18 MeSH Terms
An ancient relative of cyclooxygenase in cyanobacteria is a linoleate 10S-dioxygenase that works in tandem with a catalase-related protein with specific 10S-hydroperoxide lyase activity.
Brash AR, Niraula NP, Boeglin WE, Mashhadi Z
(2014) J Biol Chem 289: 13101-11
MeSH Terms: Bacterial Proteins, Catalase, Nostoc, Nuclear Magnetic Resonance, Biomolecular, Oxidation-Reduction, Prostaglandin-Endoperoxide Synthases
Added January 21, 2015
0 Communities
1 Members
0 Resources
6 MeSH Terms
Cyclooxygenase metabolites in the kidney.
Harris RC, Zhang MZ
(2011) Compr Physiol 1: 1729-58
MeSH Terms: Animals, Arachidonic Acid, Gene Expression, Humans, Kidney, Prostaglandin-Endoperoxide Synthases, Prostaglandins, Receptors, Prostaglandin
Added February 26, 2014
1 Communities
2 Members
0 Resources
8 MeSH Terms
Inflammatory prostaglandin E2 signaling in a mouse model of Alzheimer disease.
Shi J, Wang Q, Johansson JU, Liang X, Woodling NS, Priyam P, Loui TM, Merchant M, Breyer RM, Montine TJ, Andreasson K
(2012) Ann Neurol 72: 788-98
MeSH Terms: Age Factors, Alzheimer Disease, Amyloid Precursor Protein Secretases, Amyloid beta-Peptides, Amyloid beta-Protein Precursor, Analysis of Variance, Animals, Animals, Newborn, Aspartic Acid Endopeptidases, Brain, Calcium-Binding Proteins, Cells, Cultured, Cognitive Dysfunction, DNA-Binding Proteins, Dinoprostone, Disease Models, Animal, Encephalitis, Female, Gene Expression Regulation, Glial Fibrillary Acidic Protein, Humans, Male, Mice, Mice, Inbred C57BL, Mice, Transgenic, Microfilament Proteins, Microtubule-Associated Proteins, Mutation, Neurons, Oxidative Stress, Peptide Fragments, Prostaglandin-Endoperoxide Synthases, RNA, Messenger, Receptors, Prostaglandin E, EP3 Subtype, Signal Transduction, Synaptosomal-Associated Protein 25, Vesicle-Associated Membrane Protein 2
Added December 21, 2013
2 Communities
1 Members
0 Resources
37 MeSH Terms