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IRE1α-XBP1 signaling in leukocytes controls prostaglandin biosynthesis and pain.
Chopra S, Giovanelli P, Alvarado-Vazquez PA, Alonso S, Song M, Sandoval TA, Chae CS, Tan C, Fonseca MM, Gutierrez S, Jimenez L, Subbaramaiah K, Iwawaki T, Kingsley PJ, Marnett LJ, Kossenkov AV, Crespo MS, Dannenberg AJ, Glimcher LH, Romero-Sandoval EA, Cubillos-Ruiz JR
(2019) Science 365:
MeSH Terms: Animals, Cells, Cultured, Cyclooxygenase 2, Dinoprostone, Endoribonucleases, Humans, Leukocytes, Mice, Mice, Inbred C57BL, Myeloid Cells, Pain, Postoperative, Promoter Regions, Genetic, Prostaglandin-E Synthases, Protein Serine-Threonine Kinases, Signal Transduction, Unfolded Protein Response, Visceral Pain, X-Box Binding Protein 1
Added March 12, 2020
0 Communities
1 Members
0 Resources
18 MeSH Terms
mPGES-1-Mediated Production of PGE and EP4 Receptor Sensing Regulate T Cell Colonic Inflammation.
Maseda D, Banerjee A, Johnson EM, Washington MK, Kim H, Lau KS, Crofford LJ
(2018) Front Immunol 9: 2954
MeSH Terms: Animals, CD4-Positive T-Lymphocytes, Colitis, Dinoprostone, Intestinal Mucosa, Mice, Inbred C57BL, Mice, Knockout, Mice, Transgenic, Nuclear Receptor Subfamily 1, Group F, Member 3, Prostaglandin-E Synthases, Receptors, Prostaglandin E, EP2 Subtype, Receptors, Prostaglandin E, EP4 Subtype, T-Lymphocytes, T-Lymphocytes, Regulatory
Added March 25, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
Protective Role of mPGES-1 (Microsomal Prostaglandin E Synthase-1)-Derived PGE (Prostaglandin E) and the Endothelial EP4 (Prostaglandin E Receptor) in Vascular Responses to Injury.
Hao H, Hu S, Wan Q, Xu C, Chen H, Zhu L, Xu Z, Meng J, Breyer RM, Li N, Liu DP, FitzGerald GA, Wang M
(2018) Arterioscler Thromb Vasc Biol 38: 1115-1124
MeSH Terms: Animals, Cell Adhesion, Cell Proliferation, Cells, Cultured, Dinoprostone, Disease Models, Animal, Endothelial Cells, Female, Femoral Artery, Humans, Leukocytes, Male, Mice, Inbred C57BL, Mice, Knockout, Muscle, Smooth, Neointima, Prostaglandin-E Synthases, Re-Epithelialization, Receptors, Epoprostenol, Receptors, Prostaglandin E, EP4 Subtype, Signal Transduction, Vascular System Injuries
Added May 29, 2018
1 Communities
0 Members
0 Resources
22 MeSH Terms
mPGES1-Dependent Prostaglandin E (PGE) Controls Antigen-Specific Th17 and Th1 Responses by Regulating T Autocrine and Paracrine PGE Production.
Maseda D, Johnson EM, Nyhoff LE, Baron B, Kojima F, Wilhelm AJ, Ward MR, Woodward JG, Brand DD, Crofford LJ
(2018) J Immunol 200: 725-736
MeSH Terms: Animals, Autocrine Communication, Dinoprostone, Epitopes, T-Lymphocyte, Gene Expression Regulation, Immunization, Immunomodulation, Lymphocyte Activation, Mice, Paracrine Communication, Phenotype, Prostaglandin-E Synthases, Receptors, Prostaglandin E, EP2 Subtype, Receptors, Prostaglandin E, EP4 Subtype, Th1 Cells, Th17 Cells
Added March 25, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
Oxicams, a class of nonsteroidal anti-inflammatory drugs and beyond.
Xu S, Rouzer CA, Marnett LJ
(2014) IUBMB Life 66: 803-11
MeSH Terms: Anti-Inflammatory Agents, Non-Steroidal, Humans, Inflammation, Intramolecular Oxidoreductases, Meloxicam, Piroxicam, Prostaglandin-E Synthases, Thiazines, Thiazoles
Added February 22, 2016
0 Communities
2 Members
0 Resources
9 MeSH Terms
Reduced T cell-dependent humoral immune response in microsomal prostaglandin E synthase-1 null mice is mediated by nonhematopoietic cells.
Kojima F, Frolov A, Matnani R, Woodward JG, Crofford LJ
(2013) J Immunol 191: 4979-88
MeSH Terms: Animals, Arthritis, Experimental, Bone Marrow Transplantation, Cells, Cultured, Collagen, Female, Immunity, Humoral, Immunoglobulin G, Immunoglobulin M, Interferon-gamma, Interleukin-17, Interleukin-2, Interleukin-4, Intramolecular Oxidoreductases, Male, Mice, Mice, Inbred DBA, Mice, Knockout, Prostaglandin-E Synthases, T-Lymphocytes
Added January 21, 2015
0 Communities
1 Members
0 Resources
20 MeSH Terms
Anti-inflammatory properties of prostaglandin E2: deletion of microsomal prostaglandin E synthase-1 exacerbates non-immune inflammatory arthritis in mice.
Frolov A, Yang L, Dong H, Hammock BD, Crofford LJ
(2013) Prostaglandins Leukot Essent Fatty Acids 89: 351-8
MeSH Terms: Animals, Arthritis, Experimental, Autoantibodies, Chromatography, Liquid, Collagen Type II, Dinoprostone, Female, Gene Deletion, Inflammation, Intramolecular Oxidoreductases, Joints, Lipid Metabolism, Macrophages, Male, Mice, Neutrophil Infiltration, Neutrophils, Prostaglandin-E Synthases, Severity of Illness Index, Tandem Mass Spectrometry
Added January 21, 2015
0 Communities
1 Members
0 Resources
20 MeSH Terms
Prostaglandin E2 deficiency uncovers a dominant role for thromboxane A2 in house dust mite-induced allergic pulmonary inflammation.
Liu T, Laidlaw TM, Feng C, Xing W, Shen S, Milne GL, Boyce JA
(2012) Proc Natl Acad Sci U S A 109: 12692-7
MeSH Terms: Allergens, Animals, Antigens, Dermatophagoides, Asthma, Dinoprostone, Intercellular Adhesion Molecule-1, Intramolecular Oxidoreductases, Male, Mice, Mice, Knockout, Pneumonia, Prostaglandin-E Synthases, Pulmonary Eosinophilia, Receptors, Prostaglandin E, EP1 Subtype, Receptors, Prostaglandin E, EP2 Subtype, Receptors, Thromboxane, Signal Transduction, Thromboxane A2, Up-Regulation
Added March 26, 2014
1 Communities
1 Members
0 Resources
19 MeSH Terms
Observation of two modes of inhibition of human microsomal prostaglandin E synthase 1 by the cyclopentenone 15-deoxy-Δ(12,14)-prostaglandin J(2).
Prage EB, Morgenstern R, Jakobsson PJ, Stec DF, Voehler MW, Armstrong RN
(2012) Biochemistry 51: 2348-56
MeSH Terms: Anti-Inflammatory Agents, Binding Sites, Glutathione, Humans, Inflammation, Intramolecular Oxidoreductases, Mass Spectrometry, Microsomes, Prostaglandin D2, Prostaglandin-E Synthases
Added March 3, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
mPGES-1 null mice are resistant to bleomycin-induced skin fibrosis.
McCann MR, Monemdjou R, Ghassemi-Kakroodi P, Fahmi H, Perez G, Liu S, Shi-Wen X, Parapuram SK, Kojima F, Denton CP, Abraham DJ, Martel-Pelletier J, Crofford LJ, Leask A, Kapoor M
(2011) Arthritis Res Ther 13: R6
MeSH Terms: Animals, Antibiotics, Antineoplastic, Bleomycin, Blotting, Western, Disease Models, Animal, Female, Fibroblasts, Fibrosis, Fluorescent Antibody Technique, Immunohistochemistry, Intramolecular Oxidoreductases, Male, Mice, Mice, Knockout, Prostaglandin-E Synthases, Scleroderma, Systemic
Added September 18, 2013
0 Communities
1 Members
0 Resources
16 MeSH Terms