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Results: 1 to 10 of 122

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Central EP3 (E Prostanoid 3) Receptors Mediate Salt-Sensitive Hypertension and Immune Activation.
Xiao L, Itani HA, do Carmo LS, Carver LS, Breyer RM, Harrison DG
(2019) Hypertension 74: 1507-1515
MeSH Terms: Adaptive Immunity, Analysis of Variance, Animals, Biomarkers, Biopsy, Needle, Brain, Dinoprostone, Disease Models, Animal, Female, Flow Cytometry, Hypertension, Immunohistochemistry, Male, Mice, Mice, Inbred C57BL, NG-Nitroarginine Methyl Ester, Random Allocation, Real-Time Polymerase Chain Reaction, Receptors, Prostaglandin E, EP3 Subtype, Sodium, Dietary
Added December 3, 2019
1 Communities
0 Members
0 Resources
20 MeSH Terms
The effect of the EP3 antagonist DG-041 on male mice with diet-induced obesity.
Ceddia RP, Downey JD, Morrison RD, Kraemer MP, Davis SE, Wu J, Lindsley CW, Yin H, Daniels JS, Breyer RM
(2019) Prostaglandins Other Lipid Mediat 144: 106353
MeSH Terms: Acrylamides, Animals, Blood Pressure, Body Weight, Diet, High-Fat, HEK293 Cells, Humans, Insulin Resistance, Male, Mice, Muscle, Skeletal, Obesity, Phenotype, Receptors, Prostaglandin E, EP3 Subtype, Sulfones, Triglycerides
Added September 4, 2019
0 Communities
1 Members
0 Resources
16 MeSH Terms
mPGES-1-Mediated Production of PGE and EP4 Receptor Sensing Regulate T Cell Colonic Inflammation.
Maseda D, Banerjee A, Johnson EM, Washington MK, Kim H, Lau KS, Crofford LJ
(2018) Front Immunol 9: 2954
MeSH Terms: Animals, CD4-Positive T-Lymphocytes, Colitis, Dinoprostone, Intestinal Mucosa, Mice, Inbred C57BL, Mice, Knockout, Mice, Transgenic, Nuclear Receptor Subfamily 1, Group F, Member 3, Prostaglandin-E Synthases, Receptors, Prostaglandin E, EP2 Subtype, Receptors, Prostaglandin E, EP4 Subtype, T-Lymphocytes, T-Lymphocytes, Regulatory
Added March 25, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
Intestinal host defense outcome is dictated by PGE production during efferocytosis of infected cells.
Dejani NN, Orlando AB, Niño VE, Penteado LA, Verdan FF, Bazzano JMR, Codo AC, Salina ACG, Saraiva AC, Avelar MR, Spolidorio LC, Serezani CH, Medeiros AI
(2018) Proc Natl Acad Sci U S A 115: E8469-E8478
MeSH Terms: Animals, Citrobacter rodentium, Colitis, Dendritic Cells, Dinoprostone, Enterobacteriaceae Infections, Female, Intestines, Macrophages, Mice, Receptors, Prostaglandin E, EP4 Subtype
Added March 18, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
Protective Role of mPGES-1 (Microsomal Prostaglandin E Synthase-1)-Derived PGE (Prostaglandin E) and the Endothelial EP4 (Prostaglandin E Receptor) in Vascular Responses to Injury.
Hao H, Hu S, Wan Q, Xu C, Chen H, Zhu L, Xu Z, Meng J, Breyer RM, Li N, Liu DP, FitzGerald GA, Wang M
(2018) Arterioscler Thromb Vasc Biol 38: 1115-1124
MeSH Terms: Animals, Cell Adhesion, Cell Proliferation, Cells, Cultured, Dinoprostone, Disease Models, Animal, Endothelial Cells, Female, Femoral Artery, Humans, Leukocytes, Male, Mice, Inbred C57BL, Mice, Knockout, Muscle, Smooth, Neointima, Prostaglandin-E Synthases, Re-Epithelialization, Receptors, Epoprostenol, Receptors, Prostaglandin E, EP4 Subtype, Signal Transduction, Vascular System Injuries
Added May 29, 2018
1 Communities
0 Members
0 Resources
22 MeSH Terms
mPGES1-Dependent Prostaglandin E (PGE) Controls Antigen-Specific Th17 and Th1 Responses by Regulating T Autocrine and Paracrine PGE Production.
Maseda D, Johnson EM, Nyhoff LE, Baron B, Kojima F, Wilhelm AJ, Ward MR, Woodward JG, Brand DD, Crofford LJ
(2018) J Immunol 200: 725-736
MeSH Terms: Animals, Autocrine Communication, Dinoprostone, Epitopes, T-Lymphocyte, Gene Expression Regulation, Immunization, Immunomodulation, Lymphocyte Activation, Mice, Paracrine Communication, Phenotype, Prostaglandin-E Synthases, Receptors, Prostaglandin E, EP2 Subtype, Receptors, Prostaglandin E, EP4 Subtype, Th1 Cells, Th17 Cells
Added March 25, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
Efferocytosis-induced prostaglandin E2 production impairs alveolar macrophage effector functions during Streptococcus pneumoniae infection.
Salina AC, Souza TP, Serezani CH, Medeiros AI
(2017) Innate Immun 23: 219-227
MeSH Terms: Animals, Apoptosis, Bacteriolysis, Cyclic AMP, Cyclic AMP-Dependent Protein Kinases, Dinoprostone, Female, Homeostasis, Humans, Hydrogen Peroxide, Jurkat Cells, Macrophages, Alveolar, Phagocytosis, Pneumococcal Infections, Rats, Rats, Wistar, Receptors, Prostaglandin E, EP2 Subtype, Receptors, Prostaglandin E, EP4 Subtype, Signal Transduction, Streptococcus pneumoniae
Added May 4, 2017
0 Communities
1 Members
0 Resources
20 MeSH Terms
Macrophage Cyclooxygenase-2 Protects Against Development of Diabetic Nephropathy.
Wang X, Yao B, Wang Y, Fan X, Wang S, Niu A, Yang H, Fogo A, Zhang MZ, Harris RC
(2017) Diabetes 66: 494-504
MeSH Terms: Albuminuria, Animals, Cells, Cultured, Cyclooxygenase 2, Diabetes Mellitus, Experimental, Diabetes Mellitus, Type 1, Diabetic Nephropathies, Fibrosis, Immunoblotting, Immunohistochemistry, Kidney, Macrophages, Male, Mice, Mice, Knockout, NF-kappa B, Neutrophil Infiltration, Neutrophils, Nitric Oxide Synthase Type II, Real-Time Polymerase Chain Reaction, Receptors, Prostaglandin E, Receptors, Prostaglandin E, EP4 Subtype, Signal Transduction, T-Lymphocytes
Added April 26, 2017
1 Communities
1 Members
0 Resources
24 MeSH Terms
Prostaglandin E2 receptor EP3 regulates both adipogenesis and lipolysis in mouse white adipose tissue.
Xu H, Fu JL, Miao YF, Wang CJ, Han QF, Li S, Huang SZ, Du SN, Qiu YX, Yang JC, Gustafsson JÅ, Breyer RM, Zheng F, Wang NP, Zhang XY, Guan YF
(2016) J Mol Cell Biol 8: 518-529
MeSH Terms: Adipocytes, Adipogenesis, Adipose Tissue, White, Animals, Cell Differentiation, Gene Deletion, Inflammation, Insulin Resistance, Lipolysis, Lipoproteins, VLDL, Mice, Mice, Obese, Obesity, Phenotype, Protein Isoforms, Rats, Sprague-Dawley, Receptors, Prostaglandin E, EP3 Subtype, Signal Transduction, Triglycerides
Added February 7, 2019
1 Communities
0 Members
0 Resources
MeSH Terms
Regulation of arterial reactivity by concurrent signaling through the E-prostanoid receptor 3 and angiotensin receptor 1.
Kraemer MP, Choi H, Reese J, Lamb FS, Breyer RM
(2016) Vascul Pharmacol 84: 47-54
MeSH Terms: Angiotensin II, Animals, Calcium, Dinoprostone, Dose-Response Relationship, Drug, Femoral Artery, Focal Adhesion Kinase 2, Male, Mice, Mice, Inbred C57BL, Mice, Knockout, Receptor, Angiotensin, Type 1, Receptors, Prostaglandin E, EP3 Subtype, Vasoconstriction, rho-Associated Kinases
Added April 6, 2017
0 Communities
2 Members
0 Resources
15 MeSH Terms