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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 20

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Metabolic coessentiality mapping identifies C12orf49 as a regulator of SREBP processing and cholesterol metabolism.
Bayraktar EC, La K, Karpman K, Unlu G, Ozerdem C, Ritter DJ, Alwaseem H, Molina H, Hoffmann HH, Millner A, Atilla-Gokcumen GE, Gamazon ER, Rushing AR, Knapik EW, Basu S, Birsoy K
(2020) Nat Metab 2: 487-498
MeSH Terms: Animals, Cell Line, Cell Proliferation, Cholesterol, Gene Expression Regulation, Golgi Apparatus, Humans, Hyperlipidemias, Lipid Metabolism, Membrane Proteins, Proprotein Convertases, Serine Endopeptidases, Sterol Regulatory Element Binding Proteins, Zebrafish
Added September 9, 2020
0 Communities
1 Members
0 Resources
14 MeSH Terms
Proprotein Convertase Processing Enhances Peroxidasin Activity to Reinforce Collagen IV.
Colon S, Bhave G
(2016) J Biol Chem 291: 24009-24016
MeSH Terms: Basement Membrane, Collagen Type IV, Extracellular Matrix Proteins, HEK293 Cells, Humans, Peroxidase, Proprotein Convertases, Protein Domains
Added March 3, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
Local effects of human PCSK9 on the atherosclerotic lesion.
Giunzioni I, Tavori H, Covarrubias R, Major AS, Ding L, Zhang Y, DeVay RM, Hong L, Fan D, Predazzi IM, Rashid S, Linton MF, Fazio S
(2016) J Pathol 238: 52-62
MeSH Terms: Animals, Atherosclerosis, Disease Models, Animal, Flow Cytometry, Fluorescent Antibody Technique, Humans, Immunohistochemistry, Immunoprecipitation, Macrophages, Peritoneal, Mice, Mice, Inbred C57BL, Mice, Knockout, Mice, Transgenic, Proprotein Convertase 9, Proprotein Convertases, Receptors, LDL, Serine Endopeptidases, Transplantation Chimera
Added February 3, 2017
1 Communities
2 Members
0 Resources
18 MeSH Terms
Response to letter regarding article, "Proprotein convertase subtilisin kexin type 9 promotes intestinal overproduction of triglyceride-rich apolipoprotein B lipoproteins through both low-density lipoprotein receptor-dependent and -independent mechanisms".
Rashid S, Tavori H, Brown PE, Linton MF, He J, Giunzioni I, Fazio S
(2015) Circulation 131: e428
MeSH Terms: Animals, Apolipoproteins B, Enterocytes, Humans, Hypertriglyceridemia, Proprotein Convertases, Receptors, LDL, Serine Endopeptidases, Triglycerides
Added April 10, 2018
0 Communities
1 Members
0 Resources
MeSH Terms
PCSK9 is a critical regulator of the innate immune response and septic shock outcome.
Walley KR, Thain KR, Russell JA, Reilly MP, Meyer NJ, Ferguson JF, Christie JD, Nakada TA, Fjell CD, Thair SA, Cirstea MS, Boyd JH
(2014) Sci Transl Med 6: 258ra143
MeSH Terms: Animals, Disease Models, Animal, Genetic Variation, Hep G2 Cells, Humans, Immunity, Innate, Lipopolysaccharides, Male, Mice, Inbred C57BL, Mice, Knockout, Proprotein Convertase 9, Proprotein Convertases, Serine Endopeptidases, Shock, Septic
Added January 20, 2015
0 Communities
1 Members
0 Resources
14 MeSH Terms
Proprotein convertase subtilisin kexin type 9 promotes intestinal overproduction of triglyceride-rich apolipoprotein B lipoproteins through both low-density lipoprotein receptor-dependent and -independent mechanisms.
Rashid S, Tavori H, Brown PE, Linton MF, He J, Giunzioni I, Fazio S
(2014) Circulation 130: 431-41
MeSH Terms: Animals, Apolipoproteins B, Caco-2 Cells, Cell Survival, Enterocytes, Humans, Hypertriglyceridemia, Intestinal Mucosa, Intestines, Mice, Inbred C57BL, Mice, Knockout, Proprotein Convertase 9, Proprotein Convertases, RNA, Small Interfering, Receptors, LDL, Serine Endopeptidases, Transcription, Genetic, Triglycerides
Added February 12, 2015
0 Communities
1 Members
0 Resources
18 MeSH Terms
Response to Duell et al.
Tavori H, Giunzioni I, Linton MF, Fazio S
(2014) Circ Res 115: e5
MeSH Terms: Blood Component Removal, Humans, Hyperlipoproteinemia Type II, Lipoproteins, LDL, Proprotein Convertases, Serine Endopeptidases
Added February 12, 2015
0 Communities
1 Members
0 Resources
6 MeSH Terms
Loss of plasma proprotein convertase subtilisin/kexin 9 (PCSK9) after lipoprotein apheresis.
Tavori H, Giunzioni I, Linton MF, Fazio S
(2013) Circ Res 113: 1290-5
MeSH Terms: Apoptosis, Blood Component Removal, HEK293 Cells, Humans, Hyperlipoproteinemia Type II, Lipoproteins, LDL, Proprotein Convertase 9, Proprotein Convertases, Serine Endopeptidases
Added May 27, 2014
1 Communities
1 Members
0 Resources
9 MeSH Terms
Serum proprotein convertase subtilisin/kexin type 9 and cell surface low-density lipoprotein receptor: evidence for a reciprocal regulation.
Tavori H, Fan D, Blakemore JL, Yancey PG, Ding L, Linton MF, Fazio S
(2013) Circulation 127: 2403-13
MeSH Terms: Animals, Cells, Cultured, Cholesterol, Disease Models, Animal, Humans, Hypercholesterolemia, In Vitro Techniques, Male, Mice, Mice, Inbred C57BL, Mice, Knockout, Mice, Transgenic, Proprotein Convertase 9, Proprotein Convertases, Receptors, LDL, Serine Endopeptidases, Transfection
Added December 10, 2013
0 Communities
1 Members
0 Resources
17 MeSH Terms
Proprotein convertase subtilisin/kexin type 9 as transducer of physiologic influences on cellular cholesterol: a case for resistin.
Fazio S, Linton MF
(2012) J Am Coll Cardiol 59: 1706-8
MeSH Terms: Dyslipidemias, Hepatocytes, Humans, Proprotein Convertases, Receptors, LDL, Resistin, Subtilisin
Added December 10, 2013
0 Communities
2 Members
0 Resources
7 MeSH Terms