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The impact of sex on gene expression across human tissues.
Oliva M, Muñoz-Aguirre M, Kim-Hellmuth S, Wucher V, Gewirtz ADH, Cotter DJ, Parsana P, Kasela S, Balliu B, Viñuela A, Castel SE, Mohammadi P, Aguet F, Zou Y, Khramtsova EA, Skol AD, Garrido-Martín D, Reverter F, Brown A, Evans P, Gamazon ER, Payne A, Bonazzola R, Barbeira AN, Hamel AR, Martinez-Perez A, Soria JM, GTEx Consortium, Pierce BL, Stephens M, Eskin E, Dermitzakis ET, Segrè AV, Im HK, Engelhardt BE, Ardlie KG, Montgomery SB, Battle AJ, Lappalainen T, Guigó R, Stranger BE
(2020) Science 369:
MeSH Terms: Chromosomes, Human, X, Disease, Epigenesis, Genetic, Female, Gene Expression, Gene Expression Regulation, Genetic Variation, Genome-Wide Association Study, Humans, Male, Organ Specificity, Promoter Regions, Genetic, Quantitative Trait Loci, Sex Characteristics, Sex Factors
Added September 15, 2020
0 Communities
1 Members
0 Resources
15 MeSH Terms
IRE1α-XBP1 signaling in leukocytes controls prostaglandin biosynthesis and pain.
Chopra S, Giovanelli P, Alvarado-Vazquez PA, Alonso S, Song M, Sandoval TA, Chae CS, Tan C, Fonseca MM, Gutierrez S, Jimenez L, Subbaramaiah K, Iwawaki T, Kingsley PJ, Marnett LJ, Kossenkov AV, Crespo MS, Dannenberg AJ, Glimcher LH, Romero-Sandoval EA, Cubillos-Ruiz JR
(2019) Science 365:
MeSH Terms: Animals, Cells, Cultured, Cyclooxygenase 2, Dinoprostone, Endoribonucleases, Humans, Leukocytes, Mice, Mice, Inbred C57BL, Myeloid Cells, Pain, Postoperative, Promoter Regions, Genetic, Prostaglandin-E Synthases, Protein Serine-Threonine Kinases, Signal Transduction, Unfolded Protein Response, Visceral Pain, X-Box Binding Protein 1
Added March 12, 2020
0 Communities
1 Members
0 Resources
18 MeSH Terms
Sequence Characteristics Distinguish Transcribed Enhancers from Promoters and Predict Their Breadth of Activity.
Colbran LL, Chen L, Capra JA
(2019) Genetics 211: 1205-1217
MeSH Terms: Base Composition, Enhancer Elements, Genetic, Histone Code, Humans, Models, Genetic, Promoter Regions, Genetic, Support Vector Machine, Transcription Factors, Transcriptional Activation
Added March 3, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
Transgene-associated human growth hormone expression in pancreatic β-cells impairs identification of sex-based gene expression differences.
Stancill JS, Osipovich AB, Cartailler JP, Magnuson MA
(2019) Am J Physiol Endocrinol Metab 316: E196-E209
MeSH Terms: Animals, Female, Gene Expression, Genes, Reporter, Green Fluorescent Proteins, Homeobox Protein Nkx-2.2, Homeodomain Proteins, Human Growth Hormone, Humans, Insulin, Insulin-Secreting Cells, Male, Mice, Mice, Transgenic, Nuclear Proteins, Promoter Regions, Genetic, RNA, Messenger, Sex Factors, Transcription Factors, Transgenes
Added December 14, 2018
1 Communities
3 Members
1 Resources
20 MeSH Terms
Immunity drives regulation in cancer through NF-κB.
Collignon E, Canale A, Al Wardi C, Bizet M, Calonne E, Dedeurwaerder S, Garaud S, Naveaux C, Barham W, Wilson A, Bouchat S, Hubert P, Van Lint C, Yull F, Sotiriou C, Willard-Gallo K, Noel A, Fuks F
(2018) Sci Adv 4: eaap7309
MeSH Terms: Adaptive Immunity, Biomarkers, DNA Methylation, Epigenesis, Genetic, Gene Expression Profiling, Gene Expression Regulation, Neoplastic, Humans, Immunity, Immunity, Innate, Mixed Function Oxygenases, NF-kappa B, Neoplasms, Neoplasms, Basal Cell, Promoter Regions, Genetic, Protein Binding, Proto-Oncogene Proteins
Added March 31, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
lncRNA Epigenetic Landscape Analysis Identifies EPIC1 as an Oncogenic lncRNA that Interacts with MYC and Promotes Cell-Cycle Progression in Cancer.
Wang Z, Yang B, Zhang M, Guo W, Wu Z, Wang Y, Jia L, Li S, Cancer Genome Atlas Research Network, Xie W, Yang D
(2018) Cancer Cell 33: 706-720.e9
MeSH Terms: Animals, Binding Sites, Breast Neoplasms, Cell Cycle, Cell Line, Tumor, CpG Islands, DNA Methylation, Epigenesis, Genetic, Female, Gene Expression Regulation, Neoplastic, Humans, Mice, Neoplasm Transplantation, Prognosis, Promoter Regions, Genetic, Proto-Oncogene Proteins c-myc, RNA, Long Noncoding, Up-Regulation
Added October 30, 2019
0 Communities
1 Members
0 Resources
MeSH Terms
An integrative functional genomics framework for effective identification of novel regulatory variants in genome-phenome studies.
Zhao J, Cheng F, Jia P, Cox N, Denny JC, Zhao Z
(2018) Genome Med 10: 7
MeSH Terms: Gene Regulatory Networks, Genetic Predisposition to Disease, Genome, Human, Genome-Wide Association Study, Genomics, Humans, Molecular Sequence Annotation, Organ Specificity, Phenotype, Polymorphism, Single Nucleotide, Promoter Regions, Genetic, Transcription Factors
Added March 14, 2018
0 Communities
2 Members
0 Resources
12 MeSH Terms
DNA methyltransferase inhibition upregulates MHC-I to potentiate cytotoxic T lymphocyte responses in breast cancer.
Luo N, Nixon MJ, Gonzalez-Ericsson PI, Sanchez V, Opalenik SR, Li H, Zahnow CA, Nickels ML, Liu F, Tantawy MN, Sanders ME, Manning HC, Balko JM
(2018) Nat Commun 9: 248
MeSH Terms: Animals, Antineoplastic Agents, Azacitidine, Breast Neoplasms, Cell Line, Tumor, DNA (Cytosine-5-)-Methyltransferase 1, Female, Gene Expression Regulation, Enzymologic, Gene Expression Regulation, Neoplastic, Genes, MHC Class I, Humans, Mammary Neoplasms, Experimental, Mice, Promoter Regions, Genetic, T-Lymphocytes, Cytotoxic
Added March 14, 2018
0 Communities
4 Members
0 Resources
15 MeSH Terms
Transposable Element Exaptation into Regulatory Regions Is Rare, Influenced by Evolutionary Age, and Subject to Pleiotropic Constraints.
Simonti CN, Pavlicev M, Capra JA
(2017) Mol Biol Evol 34: 2856-2869
MeSH Terms: Animals, Biological Evolution, DNA Transposable Elements, Gene Expression Regulation, Genetic Pleiotropy, Humans, Mice, Promoter Regions, Genetic, Regulatory Sequences, Nucleic Acid
Added March 14, 2018
0 Communities
1 Members
0 Resources
9 MeSH Terms
Expression of receptor-type protein tyrosine phosphatase in developing and adult renal vasculature.
Takahashi K, Kim R, Lauhan C, Park Y, Nguyen NG, Vestweber D, Dominguez MG, Valenzuela DM, Murphy AJ, Yancopoulos GD, Gale NW, Takahashi T
(2017) PLoS One 12: e0177192
MeSH Terms: Animals, Endothelium, Vascular, Kidney, Mice, Phosphorylation, Promoter Regions, Genetic, Protein Tyrosine Phosphatases, Receptor Protein-Tyrosine Kinases
Added April 6, 2018
0 Communities
1 Members
0 Resources
MeSH Terms