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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 11

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ERAD-icating mutant insulin promotes functional insulin secretion.
Moore DJ
(2017) Sci Transl Med 9:
MeSH Terms: Endoplasmic Reticulum, Endoplasmic Reticulum-Associated Degradation, Insulin, Insulin Secretion, Proinsulin, Protein Folding
Added January 20, 2017
0 Communities
1 Members
0 Resources
6 MeSH Terms
The granular chloride channel ClC-3 is permissive for insulin secretion.
Deriy LV, Gomez EA, Jacobson DA, Wang X, Hopson JA, Liu XY, Zhang G, Bindokas VP, Philipson LH, Nelson DJ
(2009) Cell Metab 10: 316-23
MeSH Terms: Animals, Blood Glucose, Cells, Cultured, Chloride Channels, Chlorides, Cytoplasmic Granules, Exocytosis, Hydrogen-Ion Concentration, Insulin, Insulin Secretion, Insulin-Secreting Cells, Male, Mice, Mice, Knockout, Proinsulin
Added February 12, 2015
0 Communities
1 Members
0 Resources
15 MeSH Terms
Insulin gene mutations as a cause of permanent neonatal diabetes.
St√ły J, Edghill EL, Flanagan SE, Ye H, Paz VP, Pluzhnikov A, Below JE, Hayes MG, Cox NJ, Lipkind GM, Lipton RB, Greeley SA, Patch AM, Ellard S, Steiner DF, Hattersley AT, Philipson LH, Bell GI, Neonatal Diabetes International Collaborative Group
(2007) Proc Natl Acad Sci U S A 104: 15040-4
MeSH Terms: ATP-Binding Cassette Transporters, Amino Acid Sequence, Diabetes Mellitus, Female, Genetic Linkage, Heterozygote, Humans, Infant, Infant, Newborn, Insulin, Male, Models, Biological, Molecular Sequence Data, Mutation, Missense, Pedigree, Potassium Channels, Potassium Channels, Inwardly Rectifying, Proinsulin, Protein Folding, Protein Precursors, Receptors, Drug, Sulfonylurea Receptors
Added February 22, 2016
0 Communities
1 Members
0 Resources
22 MeSH Terms
PERK EIF2AK3 control of pancreatic beta cell differentiation and proliferation is required for postnatal glucose homeostasis.
Zhang W, Feng D, Li Y, Iida K, McGrath B, Cavener DR
(2006) Cell Metab 4: 491-7
MeSH Terms: Animals, Animals, Newborn, Cell Differentiation, Cell Proliferation, Diabetes Mellitus, Fetus, Gene Expression Regulation, Developmental, Gene Expression Regulation, Enzymologic, Glucose, Homeostasis, Humans, Infant, Newborn, Insulin-Secreting Cells, Mice, Mice, Knockout, Proinsulin, eIF-2 Kinase
Added August 13, 2010
1 Communities
0 Members
0 Resources
17 MeSH Terms
Regulation of two insulin granule populations within the reserve pool by distinct calcium sources.
Hao M, Li X, Rizzo MA, Rocheleau JV, Dawant BM, Piston DW
(2005) J Cell Sci 118: 5873-84
MeSH Terms: Animals, Biological Transport, Calcium, Calcium Signaling, Cell Line, Cytoskeleton, Endoplasmic Reticulum, Glucose, Humans, Image Processing, Computer-Assisted, Insulin-Secreting Cells, Microscopy, Fluorescence, Models, Biological, Proinsulin, Secretory Vesicles
Added May 5, 2017
0 Communities
2 Members
0 Resources
15 MeSH Terms
Optical imaging of pancreatic beta cells in living mice expressing a mouse insulin I promoter-firefly luciferase transgene.
Park SY, Wang X, Chen Z, Powers AC, Magnuson MA, Head WS, Piston DW, Bell GI
(2005) Genesis 43: 80-6
MeSH Terms: Animals, Cell Culture Techniques, Insulin-Secreting Cells, Luciferases, Firefly, Luminescent Agents, Mice, Mice, Transgenic, Proinsulin, Promoter Regions, Genetic, Transgenes
Added February 23, 2011
1 Communities
1 Members
0 Resources
10 MeSH Terms
Assessment of insulin secretion in the mouse.
Brissova M, Nicholson WE, Shiota M, Powers AC
(2003) Methods Mol Med 83: 23-45
MeSH Terms: Amino Acid Sequence, Animals, Blood Glucose, Glucose Tolerance Test, Immunoassay, Insulin, Insulin Secretion, Islets of Langerhans, Kinetics, Mice, Mice, Transgenic, Molecular Sequence Data, Perfusion, Proinsulin, Protein Precursors, Rats
Added December 10, 2013
0 Communities
2 Members
0 Resources
16 MeSH Terms
Alanine scanning mutants of rat proinsulin I show functional diversity of anti-insulin monoclonal antibodies.
Tikhomirov OY, Thomas JW
(2000) J Immunol 165: 3876-82
MeSH Terms: Alanine, Amino Acid Substitution, Animals, Antibodies, Monoclonal, Antibody Affinity, Antigen-Antibody Reactions, Humans, Mice, Mice, Inbred BALB C, Models, Molecular, Mutagenesis, Site-Directed, Proinsulin, Rats, Recombinant Fusion Proteins, Recombinant Proteins, Swine
Added November 6, 2013
1 Communities
0 Members
0 Resources
16 MeSH Terms
Human proinsulin-specific antigenic determinants identified by monoclonal antibodies.
Madsen OD, Frank BH, Steiner DF
(1984) Diabetes 33: 1012-6
MeSH Terms: Antibodies, Monoclonal, C-Peptide, Cross Reactions, Epitopes, Humans, Insulin, Insulin Antibodies, Proinsulin
Added November 9, 2010
0 Communities
0 Members
1 Resources
8 MeSH Terms
The production and characterization of monoclonal antibodies specific for human proinsulin using a sensitive microdot assay procedure.
Madsen OD, Cohen RM, Fitch FW, Rubenstein AH, Steiner DF
(1983) Endocrinology 113: 2135-44
MeSH Terms: Animals, Antibodies, Monoclonal, Antibody Specificity, C-Peptide, Epitopes, Female, Hybridomas, Mice, Mice, Inbred BALB C, Proinsulin, Radioimmunoassay, Rats, Rats, Inbred Lew
Added November 9, 2010
0 Communities
0 Members
2 Resources
13 MeSH Terms