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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 105

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Conformational selection dominates binding of steroids to human cytochrome P450 17A1.
Guengerich FP, Wilkey CJ, Glass SM, Reddish MJ
(2019) J Biol Chem 294: 10028-10041
MeSH Terms: 17-alpha-Hydroxypregnenolone, 17-alpha-Hydroxyprogesterone, Androstenes, Humans, Kinetics, Protein Conformation, Steroid 17-alpha-Hydroxylase, Substrate Specificity
Added March 3, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
Prostaglandin-Endoperoxide Synthase 1 Mediates the Timing of Parturition in Mice Despite Unhindered Uterine Contractility.
Herington JL, O'Brien C, Robuck MF, Lei W, Brown N, Slaughter JC, Paria BC, Mahadevan-Jansen A, Reese J
(2018) Endocrinology 159: 490-505
MeSH Terms: Abortifacient Agents, Steroidal, Animals, Cells, Cultured, Cervical Ripening, Cervix Uteri, Cyclooxygenase 1, Female, In Vitro Techniques, Luteolysis, Membrane Proteins, Mice, Inbred Strains, Mice, Knockout, Mifepristone, Myometrium, Ovariectomy, Oxytocics, Oxytocin, Pregnancy, Pregnancy, Prolonged, Progesterone, Uterine Contraction
Added March 31, 2018
0 Communities
2 Members
0 Resources
MeSH Terms
Kinetic processivity of the two-step oxidations of progesterone and pregnenolone to androgens by human cytochrome P450 17A1.
Gonzalez E, Guengerich FP
(2017) J Biol Chem 292: 13168-13185
MeSH Terms: 17-alpha-Hydroxypregnenolone, Androstenedione, Animals, Binding Sites, Biocatalysis, Cytochrome P-450 Enzyme Inhibitors, Cytochromes b5, Dehydroepiandrosterone, Humans, Imidazoles, Kinetics, Ligands, Models, Molecular, NADPH-Ferrihemoprotein Reductase, Naphthalenes, Oxidation-Reduction, Pregnenolone, Progesterone, Protein Conformation, Rats, Recombinant Proteins, Stereoisomerism, Steroid 17-alpha-Hydroxylase
Added March 14, 2018
0 Communities
1 Members
0 Resources
23 MeSH Terms
Mechanism of 17╬▒,20-Lyase and New Hydroxylation Reactions of Human Cytochrome P450 17A1: 18O LABELING AND OXYGEN SURROGATE EVIDENCE FOR A ROLE OF A PERFERRYL OXYGEN.
Yoshimoto FK, Gonzalez E, Auchus RJ, Guengerich FP
(2016) J Biol Chem 291: 17143-64
MeSH Terms: Humans, Hydroxylation, Isotope Labeling, Oxygen, Progesterone, Steroid 17-alpha-Hydroxylase
Added March 14, 2018
0 Communities
1 Members
0 Resources
6 MeSH Terms
The association of soy food consumption with the risk of subtype of breast cancers defined by hormone receptor and HER2 status.
Baglia ML, Zheng W, Li H, Yang G, Gao J, Gao YT, Shu XO
(2016) Int J Cancer 139: 742-8
MeSH Terms: Adult, Aged, Breast Neoplasms, Diet Surveys, Female, Follow-Up Studies, Humans, Incidence, Middle Aged, Population Surveillance, Proportional Hazards Models, Receptor, ErbB-2, Receptors, Estrogen, Receptors, Progesterone, Risk, Soy Foods
Added May 4, 2017
0 Communities
1 Members
0 Resources
16 MeSH Terms
Common gynecological challenges in adolescents with sickle cell disease.
Stimpson SJ, Rebele EC, DeBaun MR
(2016) Expert Rev Hematol 9: 187-96
MeSH Terms: Adolescent, Age Factors, Anemia, Iron-Deficiency, Anemia, Sickle Cell, Bone Density, Female, Genital Diseases, Female, Genotype, Gonadal Hormones, Hemoglobin, Sickle, Humans, Male, Menarche, Menorrhagia, Menstrual Cycle, Menstruation, Pain, Polyesters, Polystyrenes, Progesterone, Sex Factors, Vascular Diseases
Added April 7, 2016
0 Communities
2 Members
0 Resources
22 MeSH Terms
Research Resource: Correlating Human Cytochrome P450 21A2 Crystal Structure and Phenotypes of Mutations in Congenital Adrenal Hyperplasia.
Pallan PS, Lei L, Wang C, Waterman MR, Guengerich FP, Egli M
(2015) Mol Endocrinol 29: 1375-84
MeSH Terms: Adrenal Hyperplasia, Congenital, Crystallography, X-Ray, Humans, Mutation, Progesterone, Protein Folding, Steroid 21-Hydroxylase, Structure-Activity Relationship
Added March 14, 2018
0 Communities
1 Members
0 Resources
8 MeSH Terms
Human Cytochrome P450 21A2, the Major Steroid 21-Hydroxylase: STRUCTURE OF THE ENZYME┬ĚPROGESTERONE SUBSTRATE COMPLEX AND RATE-LIMITING C-H BOND CLEAVAGE.
Pallan PS, Wang C, Lei L, Yoshimoto FK, Auchus RJ, Waterman MR, Guengerich FP, Egli M
(2015) J Biol Chem 290: 13128-43
MeSH Terms: Amino Acid Sequence, Animals, Binding Sites, Catalysis, Catalytic Domain, Cattle, Crystallography, X-Ray, Deuterium, Humans, Hydroxylation, Kinetics, Molecular Sequence Data, Oxidation-Reduction, Progesterone, Protein Binding, Protein Conformation, Sequence Homology, Amino Acid, Steroid 21-Hydroxylase, Substrate Specificity
Added March 14, 2018
0 Communities
1 Members
0 Resources
19 MeSH Terms
Hormonal Contraception and Risk of Psychiatric and Other Noncommunicable Diseases in HIV-Infected Women.
Castilho JL, Jenkins CA, Shepherd BE, Bebawy SS, Turner M, Sterling TR, Melekhin VV
(2015) J Womens Health (Larchmt) 24: 481-8
MeSH Terms: Adult, Cohort Studies, Contraceptive Agents, Female, Contraceptives, Oral, Hormonal, Female, HIV Infections, Humans, Incidence, Medroxyprogesterone Acetate, Mental Disorders, Middle Aged, Retrospective Studies, Risk, Sexually Transmitted Diseases, Tennessee, Young Adult
Added February 17, 2016
0 Communities
1 Members
0 Resources
16 MeSH Terms
Structural and kinetic basis of steroid 17╬▒,20-lyase activity in teleost fish cytochrome P450 17A1 and its absence in cytochrome P450 17A2.
Pallan PS, Nagy LD, Lei L, Gonzalez E, Kramlinger VM, Azumaya CM, Wawrzak Z, Waterman MR, Guengerich FP, Egli M
(2015) J Biol Chem 290: 3248-68
MeSH Terms: Amino Acid Sequence, Androstenes, Animals, Catalytic Domain, Kinetics, Molecular Docking Simulation, Molecular Sequence Data, Progesterone, Protein Binding, Steroid 17-alpha-Hydroxylase, Zebrafish, Zebrafish Proteins
Added January 20, 2015
0 Communities
2 Members
0 Resources
12 MeSH Terms