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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 24

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Mitochondrial dysfunction in the APP/PSEN1 mouse model of Alzheimer's disease and a novel protective role for ascorbate.
Dixit S, Fessel JP, Harrison FE
(2017) Free Radic Biol Med 112: 515-523
MeSH Terms: Adenosine Diphosphate, Adenosine Triphosphate, Alzheimer Disease, Amyloid beta-Protein Precursor, Animals, Antioxidants, Ascorbic Acid, Biological Transport, Disease Models, Animal, Female, Gene Expression Regulation, Heterozygote, Humans, Male, Membrane Potential, Mitochondrial, Mice, Mice, Transgenic, Mitochondria, Mutation, Oxidative Stress, Oxygen Consumption, Presenilin-1, Reactive Oxygen Species, Signal Transduction, Sodium-Coupled Vitamin C Transporters
Added March 14, 2018
0 Communities
1 Members
0 Resources
25 MeSH Terms
Aerosol Delivery of Curcumin Reduced Amyloid-β Deposition and Improved Cognitive Performance in a Transgenic Model of Alzheimer's Disease.
McClure R, Ong H, Janve V, Barton S, Zhu M, Li B, Dawes M, Jerome WG, Anderson A, Massion P, Gore JC, Pham W
(2017) J Alzheimers Dis 55: 797-811
MeSH Terms: Administration, Inhalation, Alzheimer Disease, Amyloid beta-Peptides, Amyloid beta-Protein Precursor, Analysis of Variance, Animals, Anti-Inflammatory Agents, Non-Steroidal, Cognition Disorders, Curcumin, Dendritic Spines, Disease Models, Animal, Hippocampus, Humans, Maze Learning, Memory, Short-Term, Mice, Mice, Inbred C57BL, Mice, Transgenic, Microscopy, Electron, Transmission, Mutation, Neurons, Presenilin-1
Added April 10, 2017
0 Communities
3 Members
0 Resources
22 MeSH Terms
Differential proteomic and behavioral effects of long-term voluntary exercise in wild-type and APP-overexpressing transgenics.
Rao SK, Ross JM, Harrison FE, Bernardo A, Reiserer RS, Reiserer RS, Mobley JA, McDonald MP
(2015) Neurobiol Dis 78: 45-55
MeSH Terms: Alzheimer Disease, Amyloid Precursor Protein Secretases, Amyloid beta-Protein Precursor, Animals, Aspartic Acid Endopeptidases, Behavior, Animal, Hippocampus, Mice, Mice, Transgenic, Motor Activity, Presenilin-1, Proteomics, Spatial Memory
Added May 11, 2015
0 Communities
1 Members
0 Resources
13 MeSH Terms
Vitamin C deficiency in the brain impairs cognition, increases amyloid accumulation and deposition, and oxidative stress in APP/PSEN1 and normally aging mice.
Dixit S, Bernardo A, Walker JM, Kennard JA, Kim GY, Kessler ES, Harrison FE
(2015) ACS Chem Neurosci 6: 570-81
MeSH Terms: Aging, Alzheimer Disease, Amyloid beta-Peptides, Amyloid beta-Protein Precursor, Animals, Anxiety, Ascorbic Acid, Ascorbic Acid Deficiency, Brain, Cognition Disorders, Disease Models, Animal, Female, Learning, Male, Memory, Mice, Transgenic, Motor Activity, Oxidative Stress, Peptide Fragments, Presenilin-1, Sodium-Coupled Vitamin C Transporters
Added May 11, 2015
0 Communities
1 Members
0 Resources
21 MeSH Terms
Low brain ascorbic acid increases susceptibility to seizures in mouse models of decreased brain ascorbic acid transport and Alzheimer's disease.
Warner TA, Kang JQ, Kennard JA, Harrison FE
(2015) Epilepsy Res 110: 20-5
MeSH Terms: Alzheimer Disease, Amyloid beta-Protein Precursor, Animals, Ascorbic Acid, Ascorbic Acid Deficiency, Brain, Disease Models, Animal, Electrodes, Implanted, Electroencephalography, Female, Humans, Kainic Acid, Male, Malondialdehyde, Mice, Knockout, Mice, Transgenic, Oxidative Stress, Pentylenetetrazole, Presenilin-1, Seizures, Sodium-Coupled Vitamin C Transporters
Added May 11, 2015
0 Communities
1 Members
0 Resources
21 MeSH Terms
Inhalable curcumin: offering the potential for translation to imaging and treatment of Alzheimer's disease.
McClure R, Yanagisawa D, Stec D, Abdollahian D, Koktysh D, Xhillari D, Jaeger R, Stanwood G, Chekmenev E, Tooyama I, Gore JC, Pham W
(2015) J Alzheimers Dis 44: 283-95
MeSH Terms: Administration, Inhalation, Alzheimer Disease, Amyloid beta-Protein Precursor, Animals, Anti-Inflammatory Agents, Non-Steroidal, Brain, Curcumin, Diagnostic Imaging, Disease Models, Animal, Humans, Mice, Mice, Inbred C57BL, Mice, Transgenic, Mutation, Plaque, Amyloid, Presenilin-1, Tissue Distribution
Added January 20, 2015
0 Communities
4 Members
0 Resources
17 MeSH Terms
Intravenous ascorbate improves spatial memory in middle-aged APP/PSEN1 and wild type mice.
Kennard JA, Harrison FE
(2014) Behav Brain Res 264: 34-42
MeSH Terms: Administration, Intravenous, Age Factors, Amyloid beta-Peptides, Amyloid beta-Protein Precursor, Animals, Antioxidants, Ascorbic Acid, Disease Models, Animal, Hippocampus, Humans, Maze Learning, Memory Disorders, Mice, Mice, Inbred C57BL, Mice, Transgenic, Neurotransmitter Agents, Peptide Fragments, Presenilin-1, Space Perception, Time Factors
Added January 20, 2015
0 Communities
1 Members
0 Resources
20 MeSH Terms
Ultrastructural studies in APP/PS1 mice expressing human ApoE isoforms: implications for Alzheimer's disease.
Dikranian K, Kim J, Stewart FR, Levy MA, Holtzman DM
(2012) Int J Clin Exp Pathol 5: 482-95
MeSH Terms: Alzheimer Disease, Amyloid beta-Protein Precursor, Amyloidosis, Animals, Apolipoproteins E, Disease Models, Animal, Female, Humans, Male, Mice, Mice, Inbred C57BL, Mice, Transgenic, Microscopy, Electron, Transmission, Mutation, Neurons, Plaque, Amyloid, Presenilin-1, Protein Isoforms
Added September 3, 2013
0 Communities
1 Members
0 Resources
18 MeSH Terms
A role for presenilins in autophagy revisited: normal acidification of lysosomes in cells lacking PSEN1 and PSEN2.
Zhang X, Garbett K, Veeraraghavalu K, Wilburn B, Gilmore R, Mirnics K, Sisodia SS
(2012) J Neurosci 32: 8633-48
MeSH Terms: Animals, Autophagy, Basic Helix-Loop-Helix Leucine Zipper Transcription Factors, Blastocyst, Blotting, Western, Cathepsin D, Cell Line, Tumor, Cells, Cultured, DNA Primers, Gene Expression, Humans, Hydrogen-Ion Concentration, Lysosomes, Mice, Mice, Knockout, Neurons, Polymerase Chain Reaction, Presenilin-1, Presenilin-2, Presenilins, RNA, RNA, Small Interfering, Vacuolar Proton-Translocating ATPases
Added May 19, 2014
0 Communities
1 Members
0 Resources
23 MeSH Terms
Overexpression of human apolipoprotein A-I preserves cognitive function and attenuates neuroinflammation and cerebral amyloid angiopathy in a mouse model of Alzheimer disease.
Lewis TL, Cao D, Lu H, Mans RA, Su YR, Jungbauer L, Linton MF, Fazio S, LaDu MJ, Li L
(2010) J Biol Chem 285: 36958-68
MeSH Terms: Amyloid beta-Peptides, Amyloid beta-Protein Precursor, Animals, Apolipoprotein A-I, Behavior, Animal, Blotting, Western, Brain, Cells, Cultured, Cerebral Amyloid Angiopathy, Cholesterol, Cognition Disorders, Disease Models, Animal, Embryo, Mammalian, Enzyme-Linked Immunosorbent Assay, Humans, Immunoenzyme Techniques, Inflammasomes, Inflammation, Lipoproteins, Maze Learning, Mice, Mice, Inbred C57BL, Mice, Knockout, Mice, Transgenic, Microglia, Mutation, Myocytes, Smooth Muscle, Presenilin-1, RNA, Messenger, Reverse Transcriptase Polymerase Chain Reaction, Sequence Deletion, Signal Transduction
Added December 10, 2013
0 Communities
2 Members
0 Resources
32 MeSH Terms