Induction of human cytochrome P450 3A enzymes in cultured placental cells by thalidomide and relevance to bioactivation and toxicity.
Murayama N, Kazuki Y, Satoh D, Arata K, Harada T, Shibata N, Guengerich FP, Yamazaki H
(2017) J Toxicol Sci 42
: 343-348MeSH Terms: Cells, Cultured, Cytochrome P-450 CYP3A, Enzyme Induction, Female, Humans, Liver, Oxidation-Reduction, Placenta, Pregnancy, Pregnane X Receptor, RNA, Messenger, Receptors, Steroid, Rifampin, ThalidomideAdded March 14, 2018
14 MeSH Terms
Thalidomide increases human hepatic cytochrome P450 3A enzymes by direct activation of the pregnane X receptor.
Murayama N, van Beuningen R, Suemizu H, Guillouzo CG, Shibata N, Yajima K, Utoh M, Shimizu M, Chesné C, Nakamura M, Guengerich FP, Houtman R, Yamazaki H
(2014) Chem Res Toxicol 27
: 304-308MeSH Terms: Aryl Hydrocarbon Hydroxylases, Biotransformation, Cell Line, Cells, Cultured, Constitutive Androstane Receptor, Cytochrome P-450 CYP2B6, Cytochrome P-450 CYP3A, Hepatocytes, Humans, Pregnane X Receptor, Protein Array Analysis, Receptors, Cytoplasmic and Nuclear, Receptors, Steroid, ThalidomideAdded March 10, 2014
14 MeSH Terms
Fish oil and indomethacin in combination potently reduce dyslipidemia and hepatic steatosis in LDLR(-/-) mice.
Murali G, Milne GL, Webb CD, Stewart AB, McMillan RP, Lyle BC, Hulver MW, Saraswathi V
(2012) J Lipid Res 53
: 2186-2197MeSH Terms: Animals, Anti-Inflammatory Agents, Cytochrome P-450 Enzyme System, Dyslipidemias, Fatty Liver, Female, Fish Oils, Hypolipidemic Agents, Indomethacin, Liver, Mice, Pregnane X Receptor, RNA, Messenger, Receptors, LDL, Receptors, SteroidAdded March 26, 2014
15 MeSH Terms
The use of a DNA biobank linked to electronic medical records to characterize pharmacogenomic predictors of tacrolimus dose requirement in kidney transplant recipients.
Birdwell KA, Grady B, Choi L, Xu H, Bian A, Denny JC, Jiang M, Vranic G, Basford M, Cowan JD, Richardson DM, Robinson MP, Ikizler TA, Ritchie MD, Stein CM, Haas DW
(2012) Pharmacogenet Genomics 22
: 32-42MeSH Terms: ATP Binding Cassette Transporter, Subfamily B, ATP Binding Cassette Transporter, Subfamily B, Member 1, Adult, Age Factors, Body Weight, Cytochrome P-450 CYP3A, Databases, Nucleic Acid, Dose-Response Relationship, Drug, Drug Monitoring, Electronic Health Records, Female, Genetic Association Studies, Genotype, Hemoglobins, Humans, Immunosuppressive Agents, Kidney Transplantation, Linkage Disequilibrium, Male, Middle Aged, Polymorphism, Single Nucleotide, Pregnane X Receptor, Receptors, Steroid, TacrolimusAdded December 10, 2013
24 MeSH Terms
Interplay between the nuclear receptor pregnane X receptor and the uptake transporter organic anion transporter polypeptide 1A2 selectively enhances estrogen effects in breast cancer.
Meyer zu Schwabedissen HE, Tirona RG, Yip CS, Ho RH, Kim RB
(2008) Cancer Res 68
: 9338-47MeSH Terms: Breast, Breast Neoplasms, Cell Line, Tumor, Cell Proliferation, Chromatin Immunoprecipitation, Constitutive Androstane Receptor, Dipeptides, Estrogens, Estrone, Female, Humans, Neoplasm Staging, Organic Anion Transporters, Pregnane X Receptor, Promoter Regions, Genetic, Pyridines, RNA, Messenger, Receptors, Cytoplasmic and Nuclear, Receptors, Estrogen, Receptors, Steroid, Rifampin, Transcription FactorsAdded March 5, 2014
22 MeSH Terms
Impact of African herbal medicines on antiretroviral metabolism.
Mills E, Foster BC, van Heeswijk R, Phillips E, Wilson K, Leonard B, Kosuge K, Kanfer I
(2005) AIDS 19
: 95-7MeSH Terms: ATP Binding Cassette Transporter, Subfamily B, Member 1, Anti-Retroviral Agents, Aryl Hydrocarbon Hydroxylases, Cytochrome P-450 CYP3A, Fabaceae, Herb-Drug Interactions, Humans, Hypoxis, Oxidoreductases, N-Demethylating, Phytotherapy, Plant Extracts, Pregnane X Receptor, Receptors, Cytoplasmic and Nuclear, Receptors, Steroid, VerapamilAdded March 30, 2020
Identification of amino acids in rat pregnane X receptor that determine species-specific activation.
Tirona RG, Leake BF, Podust LM, Kim RB
(2004) Mol Pharmacol 65
: 36-44MeSH Terms: Amino Acid Motifs, Amino Acid Sequence, Animals, Humans, Models, Molecular, Molecular Sequence Data, Mutagenesis, Site-Directed, Pregnane X Receptor, Protein Conformation, Protein Structure, Tertiary, Rabbits, Rats, Receptors, Cytoplasmic and Nuclear, Receptors, Steroid, Recombinant Fusion Proteins, Rifampin, Sequence Homology, Amino Acid, Species Specificity, Tumor Cells, CulturedAdded March 27, 2014
19 MeSH Terms
The orphan nuclear receptor HNF4alpha determines PXR- and CAR-mediated xenobiotic induction of CYP3A4.
Tirona RG, Lee W, Leake BF, Lan LB, Cline CB, Lamba V, Parviz F, Duncan SA, Inoue Y, Gonzalez FJ, Schuetz EG, Kim RB
(2003) Nat Med 9
: 220-4MeSH Terms: Animals, Base Sequence, Basic Helix-Loop-Helix Leucine Zipper Transcription Factors, Constitutive Androstane Receptor, Cytochrome P-450 CYP3A, Cytochrome P-450 Enzyme System, DNA Primers, DNA-Binding Proteins, Electrophoretic Mobility Shift Assay, Enhancer Elements, Genetic, Enzyme Induction, Hepatocyte Nuclear Factor 4, Humans, Male, Mice, Mice, Inbred C57BL, Phosphoproteins, Pregnane X Receptor, Receptors, Cytoplasmic and Nuclear, Receptors, Steroid, Transcription Factors, Tumor Cells, Cultured, XenobioticsAdded March 27, 2014
23 MeSH Terms
Human organic anion transporting polypeptide-C (SLC21A6) is a major determinant of rifampin-mediated pregnane X receptor activation.
Tirona RG, Leake BF, Wolkoff AW, Kim RB
(2003) J Pharmacol Exp Ther 304
: 223-8MeSH Terms: Adenosine Triphosphate, Animals, Antibiotics, Antitubercular, Carrier Proteins, Cytochrome P-450 CYP3A, Cytochrome P-450 Enzyme System, DNA, Complementary, Estradiol, Genes, Reporter, Hepatocytes, Humans, In Vitro Techniques, Kinetics, Liver-Specific Organic Anion Transporter 1, Membrane Transport Proteins, Organic Anion Transporters, Sodium-Dependent, Organic Cation Transporter 1, Plasmids, Pregnane X Receptor, Rats, Receptors, Cytoplasmic and Nuclear, Receptors, Steroid, Rifampin, Symporters, Transcriptional Activation, TransfectionAdded March 27, 2014
26 MeSH Terms