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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 13

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KCNK3 Mutation Causes Altered Immune Function in Pulmonary Arterial Hypertension Patients and Mouse Models.
West JD, Austin ED, Rizzi EM, Yan L, Tanjore H, Crabtree AL, Moore CS, Muthian G, Carrier EJ, Jacobson DA, Hamid R, Kendall PL, Majka S, Rathinasabapathy A
(2021) Int J Mol Sci 22:
MeSH Terms: Animals, Biomarkers, Case-Control Studies, Cytokines, Disease Models, Animal, Disease Susceptibility, Gene Expression Profiling, Genetic Predisposition to Disease, Humans, Hypoxia, Immunomodulation, Lymphocytes, Mice, Mice, Knockout, Models, Biological, Monocytes, Mutation, Nerve Tissue Proteins, Potassium Channels, Tandem Pore Domain, Pulmonary Arterial Hypertension, Transcriptome
Added June 14, 2021
0 Communities
1 Members
0 Resources
21 MeSH Terms
TRESK and TREK-2 two-pore-domain potassium channel subunits form functional heterodimers in primary somatosensory neurons.
Lengyel M, Czirják G, Jacobson DA, Enyedi P
(2020) J Biol Chem 295: 12408-12425
MeSH Terms: Animals, HEK293 Cells, Humans, Ion Transport, Mice, Neurons, Potassium, Potassium Channels, Potassium Channels, Tandem Pore Domain, Protein Multimerization, Somatosensory Cortex, Xenopus laevis
Added June 14, 2021
0 Communities
1 Members
0 Resources
MeSH Terms
TALK-1 reduces delta-cell endoplasmic reticulum and cytoplasmic calcium levels limiting somatostatin secretion.
Vierra NC, Dickerson MT, Jordan KL, Dadi PK, Katdare KA, Altman MK, Milian SC, Jacobson DA
(2018) Mol Metab 9: 84-97
MeSH Terms: Animals, Calcium Signaling, Cells, Cultured, Cytoplasm, Endoplasmic Reticulum, Glucagon, Humans, Male, Mice, Mice, Inbred C57BL, Potassium Channels, Tandem Pore Domain, Somatostatin, Somatostatin-Secreting Cells
Added February 7, 2018
0 Communities
1 Members
0 Resources
13 MeSH Terms
Cytokine-mediated changes in K channel activity promotes an adaptive Ca response that sustains β-cell insulin secretion during inflammation.
Dickerson MT, Bogart AM, Altman MK, Milian SC, Jordan KL, Dadi PK, Jacobson DA
(2018) Sci Rep 8: 1158
MeSH Terms: Adult, Animals, Calcium, Female, Gene Expression Regulation, Glucose, Humans, Insulin, Insulin Secretion, Insulin-Secreting Cells, Interferon-gamma, Interleukin-1beta, Ion Transport, Islets of Langerhans, Male, Mice, Mice, Inbred C57BL, Mice, Knockout, Potassium, Potassium Channels, Tandem Pore Domain, Primary Cell Culture, RNA, Messenger, Sarcoplasmic Reticulum Calcium-Transporting ATPases, Tissue Culture Techniques, Tumor Necrosis Factor-alpha
Added February 7, 2018
0 Communities
1 Members
0 Resources
25 MeSH Terms
TALK-1 channels control β cell endoplasmic reticulum Ca homeostasis.
Vierra NC, Dadi PK, Milian SC, Dickerson MT, Jordan KL, Gilon P, Jacobson DA
(2017) Sci Signal 10:
MeSH Terms: Animals, Calcium, Diabetes Mellitus, Endoplasmic Reticulum, HEK293 Cells, Homeostasis, Humans, Insulin-Secreting Cells, Mice, Mice, Knockout, Potassium Channels, Tandem Pore Domain
Added November 13, 2017
0 Communities
1 Members
0 Resources
11 MeSH Terms
Osteopontin activates the diabetes-associated potassium channel TALK-1 in pancreatic β-cells.
Dickerson MT, Vierra NC, Milian SC, Dadi PK, Jacobson DA
(2017) PLoS One 12: e0175069
MeSH Terms: Aged, Animals, Calcium Signaling, Diabetes Mellitus, Type 2, Female, Glucose, HEK293 Cells, Humans, Insulin, Insulin Secretion, Insulin-Secreting Cells, Membrane Potentials, Mice, Knockout, Osteopontin, Potassium, Potassium Channels, Tandem Pore Domain
Added November 13, 2017
0 Communities
1 Members
0 Resources
16 MeSH Terms
Selective Small Molecule Activators of TREK-2 Channels Stimulate Dorsal Root Ganglion c-Fiber Nociceptor Two-Pore-Domain Potassium Channel Currents and Limit Calcium Influx.
Dadi PK, Vierra NC, Days E, Dickerson MT, Vinson PN, Weaver CD, Jacobson DA
(2017) ACS Chem Neurosci 8: 558-568
MeSH Terms: Action Potentials, Animals, Antibodies, Calcium, Dinoprostone, Electric Stimulation, Fluoxetine, Ganglia, Spinal, HEK293 Cells, Humans, Lectins, Mice, Mice, Inbred C57BL, Mutation, Nociceptors, Potassium Channel Blockers, Potassium Channels, Tandem Pore Domain, Protein Synthesis Inhibitors, Tetracycline
Added November 13, 2017
0 Communities
1 Members
0 Resources
19 MeSH Terms
Type 2 Diabetes-Associated K+ Channel TALK-1 Modulates β-Cell Electrical Excitability, Second-Phase Insulin Secretion, and Glucose Homeostasis.
Vierra NC, Dadi PK, Jeong I, Dickerson M, Powell DR, Jacobson DA
(2015) Diabetes 64: 3818-28
MeSH Terms: Animals, Blood Glucose, Diabetes Mellitus, Type 2, Homeostasis, Humans, Insulin, Insulin Secretion, Insulin-Secreting Cells, Male, Membrane Potentials, Mice, Potassium Channels, Tandem Pore Domain
Added February 22, 2016
0 Communities
1 Members
0 Resources
12 MeSH Terms
TASK-1 Potassium Channels Limit Pancreatic α-Cell Calcium Influx and Glucagon Secretion.
Dadi PK, Luo B, Vierra NC, Jacobson DA
(2015) Mol Endocrinol 29: 777-87
MeSH Terms: Animals, Calcium Signaling, Cells, Cultured, Female, Gene Expression, Glucagon, Glucagon-Secreting Cells, Glucose, Humans, Male, Membrane Potential, Mitochondrial, Mice, Inbred C57BL, Mice, Transgenic, Nerve Tissue Proteins, Potassium Channels, Tandem Pore Domain
Added April 28, 2015
0 Communities
2 Members
0 Resources
15 MeSH Terms
The genetics of pulmonary arterial hypertension.
Austin ED, Loyd JE
(2014) Circ Res 115: 189-202
MeSH Terms: Alleles, Animals, Bone Morphogenetic Protein Receptors, Type II, Caveolin 1, Epigenesis, Genetic, Familial Primary Pulmonary Hypertension, Genetic Testing, Gonadal Steroid Hormones, Humans, Hypertension, Pulmonary, Mutation, Nerve Tissue Proteins, Potassium Channels, Tandem Pore Domain, Protein Precursors, Protein-Serine-Threonine Kinases
Added February 12, 2015
0 Communities
2 Members
0 Resources
15 MeSH Terms