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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 204

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KCNK3 Mutation Causes Altered Immune Function in Pulmonary Arterial Hypertension Patients and Mouse Models.
West JD, Austin ED, Rizzi EM, Yan L, Tanjore H, Crabtree AL, Moore CS, Muthian G, Carrier EJ, Jacobson DA, Hamid R, Kendall PL, Majka S, Rathinasabapathy A
(2021) Int J Mol Sci 22:
MeSH Terms: Animals, Biomarkers, Case-Control Studies, Cytokines, Disease Models, Animal, Disease Susceptibility, Gene Expression Profiling, Genetic Predisposition to Disease, Humans, Hypoxia, Immunomodulation, Lymphocytes, Mice, Mice, Knockout, Models, Biological, Monocytes, Mutation, Nerve Tissue Proteins, Potassium Channels, Tandem Pore Domain, Pulmonary Arterial Hypertension, Transcriptome
Added June 14, 2021
0 Communities
1 Members
0 Resources
21 MeSH Terms
TRESK and TREK-2 two-pore-domain potassium channel subunits form functional heterodimers in primary somatosensory neurons.
Lengyel M, Czirják G, Jacobson DA, Enyedi P
(2020) J Biol Chem 295: 12408-12425
MeSH Terms: Animals, HEK293 Cells, Humans, Ion Transport, Mice, Neurons, Potassium, Potassium Channels, Potassium Channels, Tandem Pore Domain, Protein Multimerization, Somatosensory Cortex, Xenopus laevis
Added June 14, 2021
0 Communities
1 Members
0 Resources
MeSH Terms
An International Multicenter Evaluation of Type 5 Long QT Syndrome: A Low Penetrant Primary Arrhythmic Condition.
Roberts JD, Asaki SY, Mazzanti A, Bos JM, Tuleta I, Muir AR, Crotti L, Krahn AD, Kutyifa V, Shoemaker MB, Johnsrude CL, Aiba T, Marcondes L, Baban A, Udupa S, Dechert B, Fischbach P, Knight LM, Vittinghoff E, Kukavica D, Stallmeyer B, Giudicessi JR, Spazzolini C, Shimamoto K, Tadros R, Cadrin-Tourigny J, Duff HJ, Simpson CS, Roston TM, Wijeyeratne YD, El Hajjaji I, Yousif MD, Gula LJ, Leong-Sit P, Chavali N, Landstrom AP, Marcus GM, Dittmann S, Wilde AAM, Behr ER, Tfelt-Hansen J, Scheinman MM, Perez MV, Kaski JP, Gow RM, Drago F, Aziz PF, Abrams DJ, Gollob MH, Skinner JR, Shimizu W, Kaufman ES, Roden DM, Zareba W, Schwartz PJ, Schulze-Bahr E, Etheridge SP, Priori SG, Ackerman MJ
(2020) Circulation 141: 429-439
MeSH Terms: Adolescent, Adult, Death, Sudden, Cardiac, Electric Countershock, Electrocardiography, Female, Heart Arrest, Humans, Long QT Syndrome, Male, Middle Aged, Penetrance, Potassium Channels, Voltage-Gated, Registries
Added March 24, 2020
0 Communities
1 Members
0 Resources
14 MeSH Terms
Sign Inversion in Photopharmacology: Incorporation of Cyclic Azobenzenes in Photoswitchable Potassium Channel Blockers and Openers.
Trads JB, Hüll K, Matsuura BS, Laprell L, Fehrentz T, Görldt N, Kozek KA, Weaver CD, Klöcker N, Barber DM, Trauner D
(2019) Angew Chem Int Ed Engl 58: 15421-15428
MeSH Terms: Action Potentials, Azo Compounds, Cyclization, Drug Design, G Protein-Coupled Inwardly-Rectifying Potassium Channels, HEK293 Cells, Humans, Isomerism, Lidocaine, Light, Patch-Clamp Techniques, Potassium Channel Blockers, Thermodynamics
Added March 27, 2020
0 Communities
1 Members
0 Resources
13 MeSH Terms
Structure-Activity Relationships, Pharmacokinetics, and Pharmacodynamics of the Kir6.2/SUR1-Specific Channel Opener VU0071063.
Kharade SV, Sanchez-Andres JV, Fulton MG, Shelton EL, Blobaum AL, Engers DW, Hofmann CS, Dadi PK, Lantier L, Jacobson DA, Lindsley CW, Denton JS
(2019) J Pharmacol Exp Ther 370: 350-359
MeSH Terms: Animals, Ductus Arteriosus, Glucose, HEK293 Cells, Humans, Insulin Secretion, Insulin-Secreting Cells, Ion Channel Gating, Mice, Potassium Channels, Inwardly Rectifying, Structure-Activity Relationship, Sulfonylurea Receptors, Vasodilation, Xanthines
Added June 14, 2021
0 Communities
1 Members
0 Resources
MeSH Terms
VU0810464, a non-urea G protein-gated inwardly rectifying K (K 3/GIRK) channel activator, exhibits enhanced selectivity for neuronal K 3 channels and reduces stress-induced hyperthermia in mice.
Vo BN, Abney KK, Anderson A, Marron Fernandez de Velasco E, Benneyworth MA, Daniels JS, Morrison RD, Hopkins CR, Weaver CD, Wickman K
(2019) Br J Pharmacol 176: 2238-2249
MeSH Terms: Animals, Anxiety, Behavior, Animal, Brain, Cells, Cultured, Female, Fever, G Protein-Coupled Inwardly-Rectifying Potassium Channels, Male, Mice, Inbred C57BL, Mice, Transgenic, Neurons, Sinoatrial Node, Stress, Psychological
Added April 10, 2019
0 Communities
1 Members
0 Resources
14 MeSH Terms
Glucose-mediated inhibition of calcium-activated potassium channels limits α-cell calcium influx and glucagon secretion.
Dickerson MT, Dadi PK, Altman MK, Verlage KR, Thorson AS, Jordan KL, Vierra NC, Amarnath G, Jacobson DA
(2019) Am J Physiol Endocrinol Metab 316: E646-E659
MeSH Terms: Alkanes, Animals, Apamin, Calcium, Calcium Channels, Calcium Channels, L-Type, Calcium Channels, P-Type, Calcium Channels, Q-Type, Endoplasmic Reticulum, Glucagon, Glucagon-Secreting Cells, Glucose, Mice, Mice, Transgenic, Patch-Clamp Techniques, Peptides, Potassium Channel Blockers, Potassium Channels, Calcium-Activated, Pyrazoles, Quinolinium Compounds
Added February 13, 2019
0 Communities
1 Members
0 Resources
20 MeSH Terms
Late onset obesity in mice with targeted deletion of potassium inward rectifier Kir7.1 from cells expressing the melanocortin-4 receptor.
Anderson EJP, Ghamari-Langroudi M, Cakir I, Litt MJ, Chen V, Reggiardo RE, Millhauser GL, Cone RD
(2019) J Neuroendocrinol 31: e12670
MeSH Terms: Animals, Feeding Behavior, Female, Hypothalamus, Male, Membrane Potentials, Mice, Inbred C57BL, Mice, Knockout, Neurons, Obesity, Potassium Channels, Inwardly Rectifying, Receptor, Melanocortin, Type 4
Added January 8, 2019
1 Communities
0 Members
0 Resources
12 MeSH Terms
Analgesic Effects of the GIRK Activator, VU0466551, Alone and in Combination with Morphine in Acute and Persistent Pain Models.
Abney KK, Bubser M, Du Y, Kozek KA, Bridges TM, Linsdley CW, Daniels JS, Morrison RD, Wickman K, Hopkins CR, Jones CK, Weaver CD
(2019) ACS Chem Neurosci 10: 1294-1299
MeSH Terms: Analgesics, Animals, Disease Models, Animal, Dose-Response Relationship, Drug, Drug Therapy, Combination, Formaldehyde, G Protein-Coupled Inwardly-Rectifying Potassium Channels, HEK293 Cells, Hot Temperature, Humans, Male, Mice, Inbred C57BL, Morphine, Pain, Phenylurea Compounds, Pyrazoles
Added April 10, 2019
0 Communities
2 Members
0 Resources
16 MeSH Terms
Discovery and Characterization of VU0529331, a Synthetic Small-Molecule Activator of Homomeric G Protein-Gated, Inwardly Rectifying, Potassium (GIRK) Channels.
Kozek KA, Du Y, Sharma S, Prael FJ, Spitznagel BD, Kharade SV, Denton JS, Hopkins CR, Weaver CD
(2019) ACS Chem Neurosci 10: 358-370
MeSH Terms: Dose-Response Relationship, Drug, Drug Discovery, G Protein-Coupled Inwardly-Rectifying Potassium Channels, HEK293 Cells, Humans, Ion Channel Gating, Neurons, Pyrazines
Added April 10, 2019
0 Communities
1 Members
0 Resources
8 MeSH Terms