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Results: 1 to 10 of 10

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Structural insights into the transition of Clostridioides difficile binary toxin from prepore to pore.
Anderson DM, Sheedlo MJ, Jensen JL, Lacy DB
(2020) Nat Microbiol 5: 102-107
MeSH Terms: ADP Ribose Transferases, Bacterial Proteins, Bacterial Toxins, Caco-2 Cells, Cryoelectron Microscopy, Humans, Models, Molecular, Polysaccharides, Pore Forming Cytotoxic Proteins, Protein Binding, Protein Domains, Protein Multimerization, Receptors, LDL
Added March 24, 2020
0 Communities
1 Members
0 Resources
13 MeSH Terms
Translocation domain mutations affecting cellular toxicity identify the Clostridium difficile toxin B pore.
Zhang Z, Park M, Tam J, Auger A, Beilhartz GL, Lacy DB, Melnyk RA
(2014) Proc Natl Acad Sci U S A 111: 3721-6
MeSH Terms: Amino Acid Sequence, Bacterial Toxins, Clostridioides difficile, Fluorescence, High-Throughput Screening Assays, Models, Molecular, Molecular Sequence Data, Mutagenesis, Mutation, Pore Forming Cytotoxic Proteins, Protein Structure, Tertiary, Rubidium Radioisotopes
Added May 29, 2014
0 Communities
1 Members
0 Resources
12 MeSH Terms
Coenzyme depletion by members of the aerolysin family of pore-forming toxins leads to diminished ATP levels and cell death.
Fennessey CM, Ivie SE, McClain MS
(2012) Mol Biosyst 8: 2097-105
MeSH Terms: Adenosine Triphosphate, Aeromonas hydrophila, Bacterial Toxins, Carnitine, Cell Death, Cell Line, Coenzyme A, Humans, NAD, Pore Forming Cytotoxic Proteins
Added May 20, 2014
0 Communities
1 Members
0 Resources
10 MeSH Terms
Combination chemotherapy and radiation of human squamous cell carcinoma of the head and neck augments CTL-mediated lysis.
Gelbard A, Garnett CT, Abrams SI, Patel V, Gutkind JS, Palena C, Tsang KY, Schlom J, Hodge JW
(2006) Clin Cancer Res 12: 1897-905
MeSH Terms: Antigens, Neoplasm, Antineoplastic Agents, Carcinoembryonic Antigen, Carcinoma, Squamous Cell, Cell Line, Tumor, Cell Survival, Cisplatin, Cytotoxicity Tests, Immunologic, Cytotoxicity, Immunologic, Flow Cytometry, Fluorouracil, Gene Expression Regulation, Neoplastic, Head and Neck Neoplasms, Humans, Intercellular Adhesion Molecule-1, Membrane Glycoproteins, Mucin-1, Mucins, Perforin, Pore Forming Cytotoxic Proteins, Proto-Oncogene Proteins c-bcl-2, Receptors, Tumor Necrosis Factor, Reverse Transcriptase Polymerase Chain Reaction, Signal Transduction, T-Lymphocytes, Cytotoxic, Time Factors
Added April 11, 2014
0 Communities
1 Members
0 Resources
26 MeSH Terms
NK cells promote islet allograft tolerance via a perforin-dependent mechanism.
Beilke JN, Kuhl NR, Van Kaer L, Gill RG
(2005) Nat Med 11: 1059-65
MeSH Terms: Animals, Antibodies, Monoclonal, CD11a Antigen, CD40 Antigens, CD40 Ligand, CD8-Positive T-Lymphocytes, Graft Survival, Histocompatibility Antigens Class I, Immune Tolerance, Immunotherapy, Intercellular Adhesion Molecule-1, Islets of Langerhans Transplantation, Killer Cells, Natural, Major Histocompatibility Complex, Membrane Glycoproteins, Mice, Mice, Knockout, Models, Animal, Models, Immunological, Perforin, Phenotype, Pore Forming Cytotoxic Proteins, Transplantation, Homologous
Added December 10, 2013
0 Communities
1 Members
0 Resources
23 MeSH Terms
Differential regulation of granzyme and perforin in effector and memory T cells following smallpox immunization.
Rock MT, Yoder SM, Wright PF, Talbot TR, Edwards KM, Crowe JE
(2005) J Immunol 174: 3757-64
MeSH Terms: Adult, Antigens, Viral, CD8-Positive T-Lymphocytes, Flow Cytometry, Granzymes, Humans, Immunologic Memory, In Vitro Techniques, Lymphocyte Activation, Membrane Glycoproteins, Perforin, Phenotype, Pore Forming Cytotoxic Proteins, Serine Endopeptidases, Smallpox Vaccine, T-Lymphocyte Subsets, Time Factors, Vaccinia virus
Added August 6, 2012
0 Communities
1 Members
0 Resources
18 MeSH Terms
Plasmodium berghei infection in mice induces liver injury by an IL-12- and toll-like receptor/myeloid differentiation factor 88-dependent mechanism.
Adachi K, Tsutsui H, Kashiwamura S, Seki E, Nakano H, Takeuchi O, Takeda K, Okumura K, Van Kaer L, Okamura H, Akira S, Nakanishi K
(2001) J Immunol 167: 5928-34
MeSH Terms: Adaptor Proteins, Signal Transducing, Animals, Antigens, CD1, Antigens, CD1d, Antigens, Differentiation, Cytotoxicity Tests, Immunologic, Drosophila Proteins, Fas Ligand Protein, Female, Hepatitis, Animal, Interleukin-12, Interleukin-18, Killer Cells, Natural, Liver, Malaria, Membrane Glycoproteins, Mice, Mice, Knockout, Myeloid Differentiation Factor 88, Perforin, Plasmodium berghei, Pore Forming Cytotoxic Proteins, Receptors, Cell Surface, Receptors, Immunologic, T-Lymphocyte Subsets, Toll-Like Receptors, fas Receptor
Added December 10, 2013
0 Communities
1 Members
0 Resources
27 MeSH Terms
Critical contribution of IFN-gamma and NK cells, but not perforin-mediated cytotoxicity, to anti-metastatic effect of alpha-galactosylceramide.
Hayakawa Y, Takeda K, Yagita H, Kakuta S, Iwakura Y, Van Kaer L, Saiki I, Okumura K
(2001) Eur J Immunol 31: 1720-7
MeSH Terms: Animals, Antineoplastic Agents, Apoptosis, Cytotoxicity, Immunologic, Galactosylceramides, Interferon-gamma, Interleukin-4, Killer Cells, Natural, Lymphocyte Activation, Membrane Glycoproteins, Mice, Mice, Inbred C57BL, Neoplasm Metastasis, Perforin, Pore Forming Cytotoxic Proteins, T-Lymphocytes, Time Factors
Added December 10, 2013
0 Communities
1 Members
0 Resources
17 MeSH Terms
Critical role of NK1+ T cells in IL-12-induced immune responses in vivo.
Kawamura T, Takeda K, Mendiratta SK, Kawamura H, Van Kaer L, Yagita H, Abo T, Okumura K
(1998) J Immunol 160: 16-9
MeSH Terms: Animals, Antigens, Antigens, CD1, Antigens, Surface, Cytotoxicity, Immunologic, Fas Ligand Protein, Interleukin-12, Lectins, C-Type, Liver, Male, Membrane Glycoproteins, Mice, Mice, Inbred C57BL, Mice, Knockout, NK Cell Lectin-Like Receptor Subfamily B, Perforin, Pore Forming Cytotoxic Proteins, Proteins, Receptors, Interferon, Receptors, Interleukin, Receptors, Interleukin-12, T-Lymphocyte Subsets, Up-Regulation
Added December 10, 2013
0 Communities
1 Members
0 Resources
23 MeSH Terms
Perforin protects against autoimmunity in lupus-prone mice.
Peng SL, Moslehi J, Robert ME, Craft J
(1998) J Immunol 160: 652-60
MeSH Terms: Animals, Autoimmune Diseases, Cell Movement, Crosses, Genetic, Disease Susceptibility, Lupus Nephritis, Lymphocytes, Membrane Glycoproteins, Mice, Mice, Inbred C57BL, Mice, Inbred MRL lpr, Mice, Knockout, Perforin, Pore Forming Cytotoxic Proteins, Survival Analysis, fas Receptor
Added March 4, 2015
0 Communities
1 Members
0 Resources
16 MeSH Terms