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An analysis of genetically regulated gene expression and the role of co-expression networks across 16 psychiatric and substance use phenotypes.
Gerring ZF, Thorp JG, Gamazon ER, Derks EM
(2022) Eur J Hum Genet 30: 560-566
MeSH Terms: Autism Spectrum Disorder, Child, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Phenotype, Polymorphism, Single Nucleotide, Substance-Related Disorders, Transcriptome
Added March 21, 2022
0 Communities
1 Members
0 Resources
9 MeSH Terms
Genetically regulated expression in late-onset Alzheimer's disease implicates risk genes within known and novel loci.
Chen HH, Petty LE, Sha J, Zhao Y, Kuzma A, Valladares O, Alzheimer’s Disease Genetics Consortium, International Genomics of Alzheimer’s Project, Bush W, Naj AC, Gamazon ER, Below JE
(2021) Transl Psychiatry 11: 618
MeSH Terms: Alzheimer Disease, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Multifactorial Inheritance, Polymorphism, Single Nucleotide
Added February 15, 2022
0 Communities
1 Members
0 Resources
MeSH Terms
A transcriptome-wide association study identifies novel candidate susceptibility genes for prostate cancer risk.
Liu D, Zhu J, Zhou D, Nikas EG, Mitanis NT, Sun Y, Wu C, Mancuso N, Cox NJ, Wang L, Freedland SJ, Haiman CA, Gamazon ER, Nikas JB, Wu L
(2022) Int J Cancer 150: 80-90
MeSH Terms: Biomarkers, Tumor, Case-Control Studies, DNA Methylation, Epigenesis, Genetic, Follow-Up Studies, Gene Expression Regulation, Neoplastic, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Male, Polymorphism, Single Nucleotide, Prognosis, Prostatic Neoplasms, Quantitative Trait Loci, Transcriptome, United States
Added October 8, 2021
0 Communities
1 Members
0 Resources
16 MeSH Terms
A transcriptome-wide association study of Alzheimer's disease using prediction models of relevant tissues identifies novel candidate susceptibility genes.
Sun Y, Zhu J, Zhou D, Canchi S, Wu C, Cox NJ, Rissman RA, Gamazon ER, Wu L
(2021) Genome Med 13: 141
MeSH Terms: Alleles, Alzheimer Disease, Chromosome Mapping, Computational Biology, Databases, Genetic, Gene Expression Profiling, Gene Expression Regulation, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Models, Biological, Organ Specificity, Polymorphism, Single Nucleotide, Prognosis, Resorcinols, Signal Transduction, Transcriptome
Added October 8, 2021
0 Communities
1 Members
0 Resources
17 MeSH Terms
A transcriptome-wide association study identifies novel blood-based gene biomarker candidates for Alzheimer's disease risk.
Sun Y, Zhou D, Rahman MR, Zhu J, Ghoneim D, Cox NJ, Beach TG, Wu C, Gamazon ER, Wu L
(2021) Hum Mol Genet 31: 289-299
MeSH Terms: Alzheimer Disease, Genetic Markers, Genome-Wide Association Study, Humans, Polymorphism, Single Nucleotide, Quality of Life, Transcriptome
Added October 8, 2021
0 Communities
1 Members
0 Resources
7 MeSH Terms
Contextualizing genetic risk score for disease screening and rare variant discovery.
Zhou D, Yu D, Scharf JM, Mathews CA, McGrath L, Cook E, Lee SH, Davis LK, Gamazon ER
(2021) Nat Commun 12: 4418
MeSH Terms: Clinical Decision-Making, Datasets as Topic, Genetic Predisposition to Disease, Genetic Testing, Genome-Wide Association Study, Humans, Models, Genetic, Multifactorial Inheritance, Polymorphism, Single Nucleotide, Risk Factors, Software, Whole Genome Sequencing
Added July 22, 2021
0 Communities
1 Members
0 Resources
12 MeSH Terms
Allele-specific variation at APOE increases nonalcoholic fatty liver disease and obesity but decreases risk of Alzheimer's disease and myocardial infarction.
Palmer ND, Kahali B, Kuppa A, Chen Y, Du X, Feitosa MF, Bielak LF, O'Connell JR, Musani SK, Guo X, Smith AV, Ryan KA, Eirksdottir G, Allison MA, Bowden DW, Budoff MJ, Carr JJ, Chen YI, Taylor KD, Correa A, Crudup BF, Halligan B, Yang J, Kardia SLR, Launer LJ, Fu YP, Mosley TH, Norris JM, Terry JG, O'Donnell CJ, Rotter JI, Wagenknecht LE, Gudnason V, Province MA, Peyser PA, Speliotes EK
(2021) Hum Mol Genet 30: 1443-1456
MeSH Terms: Alanine Transaminase, Alleles, Alzheimer Disease, Apolipoproteins E, Databases, Genetic, Exome, Gene Frequency, Genome-Wide Association Study, Humans, Liver, Liver Cirrhosis, Myocardial Infarction, Non-alcoholic Fatty Liver Disease, Obesity, Phenotype, Polymorphism, Single Nucleotide, Prognosis, Risk Factors, Triglycerides
Added June 9, 2021
0 Communities
1 Members
0 Resources
19 MeSH Terms
An integrative systems-based analysis of substance use: eQTL-informed gene-based tests, gene networks, and biological mechanisms.
Gerring ZF, Vargas AM, Gamazon ER, Derks EM
(2021) Am J Med Genet B Neuropsychiatr Genet 186: 162-172
MeSH Terms: Gene Expression Profiling, Gene Regulatory Networks, Genetic Predisposition to Disease, Genetic Testing, Genome-Wide Association Study, Humans, Phenotype, Polymorphism, Single Nucleotide, Quantitative Trait Loci, Substance-Related Disorders
Added December 30, 2020
0 Communities
1 Members
0 Resources
10 MeSH Terms
A Noncoding Variant Near PPP1R3B Promotes Liver Glycogen Storage and MetS, but Protects Against Myocardial Infarction.
Kahali B, Chen Y, Feitosa MF, Bielak LF, O'Connell JR, Musani SK, Hegde Y, Chen Y, Stetson LC, Guo X, Fu YP, Smith AV, Ryan KA, Eiriksdottir G, Cohain AT, Allison M, Bakshi A, Bowden DW, Budoff MJ, Carr JJ, Carskadon S, Chen YI, Correa A, Crudup BF, Du X, Harris TB, Yang J, Kardia SLR, Launer LJ, Liu J, Mosley TH, Norris JM, Terry JG, Palanisamy N, Schadt EE, O'Donnell CJ, Yerges-Armstrong LM, Rotter JI, Wagenknecht LE, Handelman SK, Gudnason V, Province MA, Peyser PA, Halligan B, Palmer ND, Speliotes EK
(2021) J Clin Endocrinol Metab 106: 372-387
MeSH Terms: Adult, Aged, Biomarkers, Female, Follow-Up Studies, Glycogen Storage Disease, Humans, Liver Glycogen, Male, Metabolic Syndrome, Middle Aged, Myocardial Infarction, Polymorphism, Single Nucleotide, Prognosis, Prospective Studies, Protein Phosphatase 1
Added January 6, 2021
0 Communities
1 Members
0 Resources
16 MeSH Terms
A vast resource of allelic expression data spanning human tissues.
Castel SE, Aguet F, Mohammadi P, GTEx Consortium, Ardlie KG, Lappalainen T
(2020) Genome Biol 21: 234
MeSH Terms: Alleles, Gene Expression, Genome, Human, Haplotypes, Humans, Polymorphism, Single Nucleotide, Sequence Analysis, RNA
Added September 15, 2020
0 Communities
1 Members
0 Resources
7 MeSH Terms