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Results: 1 to 10 of 67

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Clopidogrel Pharmacogenetics - Why the Wait?
Roden DM
(2019) N Engl J Med 381: 1677-1678
MeSH Terms: Clopidogrel, Genotype, Percutaneous Coronary Intervention, Pharmacogenetics, Platelet Aggregation Inhibitors, Ticlopidine
Added March 24, 2020
0 Communities
1 Members
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MeSH Terms
Pharmacogenomic polygenic response score predicts ischaemic events and cardiovascular mortality in clopidogrel-treated patients.
Lewis JP, Backman JD, Reny JL, Bergmeijer TO, Mitchell BD, Ritchie MD, Déry JP, Pakyz RE, Gong L, Ryan K, Kim EY, Aradi D, Fernandez-Cadenas I, Lee MTM, Whaley RM, Montaner J, Gensini GF, Cleator JH, Chang K, Holmvang L, Hochholzer W, Roden DM, Winter S, Altman RB, Alexopoulos D, Kim HS, Gawaz M, Bliden KP, Valgimigli M, Marcucci R, Campo G, Schaeffeler E, Dridi NP, Wen MS, Shin JG, Fontana P, Giusti B, Geisler T, Kubo M, Trenk D, Siller-Matula JM, Ten Berg JM, Gurbel PA, Schwab M, Klein TE, Shuldiner AR, ICPC Investigators
(2020) Eur Heart J Cardiovasc Pharmacother 6: 203-210
MeSH Terms: Aged, Brain Ischemia, Clopidogrel, Coronary Artery Disease, Coronary Thrombosis, Decision Support Techniques, Europe, Female, Humans, Male, Middle Aged, Myocardial Infarction, Percutaneous Coronary Intervention, Pharmacogenomic Variants, Platelet Aggregation, Platelet Aggregation Inhibitors, Polymorphism, Single Nucleotide, Predictive Value of Tests, Risk Assessment, Risk Factors, Stents, Stroke, Treatment Outcome
Added March 24, 2020
0 Communities
1 Members
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23 MeSH Terms
Platelet transfusion does not improve outcomes in patients with brain injury on antiplatelet therapy.
Holzmacher JL, Reynolds C, Patel M, Maluso P, Holland S, Gamsky N, Moore H, Acquista E, Carrick M, Amdur R, Hancock H, Metzler M, Dunn J, Sarani B
(2018) Brain Inj 32: 325-330
MeSH Terms: Aged, Aged, 80 and over, Aspirin, Brain Injuries, Clopidogrel, Female, Humans, Injury Severity Score, Length of Stay, Male, Platelet Aggregation Inhibitors, Platelet Transfusion, Statistics, Nonparametric, Treatment Outcome
Added June 26, 2018
0 Communities
1 Members
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14 MeSH Terms
Multisite Investigation of Outcomes With Implementation of CYP2C19 Genotype-Guided Antiplatelet Therapy After Percutaneous Coronary Intervention.
Cavallari LH, Lee CR, Beitelshees AL, Cooper-DeHoff RM, Duarte JD, Voora D, Kimmel SE, McDonough CW, Gong Y, Dave CV, Pratt VM, Alestock TD, Anderson RD, Alsip J, Ardati AK, Brott BC, Brown L, Chumnumwat S, Clare-Salzler MJ, Coons JC, Denny JC, Dillon C, Elsey AR, Hamadeh IS, Harada S, Hillegass WB, Hines L, Horenstein RB, Howell LA, Jeng LJB, Kelemen MD, Lee YM, Magvanjav O, Montasser M, Nelson DR, Nutescu EA, Nwaba DC, Pakyz RE, Palmer K, Peterson JF, Pollin TI, Quinn AH, Robinson SW, Schub J, Skaar TC, Smith DM, Sriramoju VB, Starostik P, Stys TP, Stevenson JM, Varunok N, Vesely MR, Wake DT, Weck KE, Weitzel KW, Wilke RA, Willig J, Zhao RY, Kreutz RP, Stouffer GA, Empey PE, Limdi NA, Shuldiner AR, Winterstein AG, Johnson JA, IGNITE Network
(2018) JACC Cardiovasc Interv 11: 181-191
MeSH Terms: Aged, Clinical Decision-Making, Clopidogrel, Cytochrome P-450 CYP2C19, Drug Resistance, Female, Humans, Male, Middle Aged, Patient Selection, Percutaneous Coronary Intervention, Pharmacogenetics, Pharmacogenomic Testing, Pharmacogenomic Variants, Platelet Aggregation Inhibitors, Prasugrel Hydrochloride, Predictive Value of Tests, Risk Assessment, Risk Factors, Ticagrelor, Time Factors, Treatment Outcome, United States
Added March 14, 2018
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1 Members
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23 MeSH Terms
Identification of the minimum PAR4 inhibitor pharmacophore and optimization of a series of 2-methoxy-6-arylimidazo[2,1-b][1,3,4]thiadiazoles.
Temple KJ, Duvernay MT, Maeng JG, Blobaum AL, Stauffer SR, Hamm HE, Lindsley CW
(2016) Bioorg Med Chem Lett 26: 5481-5486
MeSH Terms: Blood Platelets, Humans, Platelet Aggregation, Platelet Aggregation Inhibitors, Receptors, Thrombin, Thiadiazoles, Thrombin
Added March 24, 2020
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1 Members
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MeSH Terms
Treatment Practices and Outcomes After Blunt Cerebrovascular Injury in Children.
Dewan MC, Ravindra VM, Gannon S, Prather CT, Yang GL, Jordan LC, Limbrick D, Jea A, Riva-Cambrin J, Naftel RP
(2016) Neurosurgery 79: 872-878
MeSH Terms: Adolescent, Age Factors, Anticoagulants, Cerebrovascular Trauma, Child, Child, Preschool, Disease Progression, Female, Glasgow Coma Scale, Humans, Male, Platelet Aggregation Inhibitors, Practice Patterns, Physicians', Retrospective Studies, Tomography, X-Ray Computed, Trauma Centers, Treatment Outcome, Wounds, Nonpenetrating
Added March 24, 2020
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1 Members
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MeSH Terms
Physician response to implementation of genotype-tailored antiplatelet therapy.
Peterson JF, Field JR, Unertl KM, Schildcrout JS, Johnson DC, Shi Y, Danciu I, Cleator JH, Pulley JM, McPherson JA, Denny JC, Laposata M, Roden DM, Johnson KB
(2016) Clin Pharmacol Ther 100: 67-74
MeSH Terms: Age Factors, Aged, Clinical Decision-Making, Clopidogrel, Cytochrome P-450 CYP2C19, Female, Genetic Variation, Genotype, Humans, Male, Middle Aged, Pharmacogenetics, Platelet Aggregation Inhibitors, Practice Patterns, Physicians', Precision Medicine, Prospective Studies, Stents, Ticlopidine
Added March 14, 2018
0 Communities
2 Members
0 Resources
18 MeSH Terms
CYP2C19 and CES1 polymorphisms and efficacy of clopidogrel and aspirin dual antiplatelet therapy in patients with symptomatic intracranial atherosclerotic disease.
Hoh BL, Gong Y, McDonough CW, Waters MF, Royster AJ, Sheehan TO, Burkley B, Langaee TY, Mocco J, Zuckerman SL, Mummareddy N, Stephens ML, Ingram C, Shaffer CM, Denny JC, Brilliant MH, Kitchner TE, Linneman JG, Roden DM, Johnson JA
(2016) J Neurosurg 124: 1746-51
MeSH Terms: Aged, Aspirin, Carboxylic Ester Hydrolases, Clopidogrel, Cytochrome P-450 CYP2C19, Female, Gene Frequency, Genotyping Techniques, Heterozygote, Humans, Intracranial Arteriosclerosis, Ischemic Attack, Transient, Kaplan-Meier Estimate, Male, Myocardial Infarction, Platelet Aggregation Inhibitors, Polymorphism, Single Nucleotide, Prospective Studies, Stroke, Ticlopidine
Added March 14, 2018
0 Communities
2 Members
0 Resources
20 MeSH Terms
Platelet response to increased aspirin dose in patients with persistent platelet aggregation while treated with aspirin 81 mg.
Gengo F, Westphal ES, Rainka MM, Janda M, Robson MJ, Hourihane JM, Bates V
(2016) J Clin Pharmacol 56: 414-21
MeSH Terms: Aspirin, Blood Coagulation Tests, Blood Platelets, Collagen, Drug Resistance, Female, Humans, Male, Middle Aged, Platelet Aggregation, Platelet Aggregation Inhibitors, Platelet Function Tests
Added August 26, 2015
0 Communities
1 Members
0 Resources
12 MeSH Terms
Platelet Inhibitors Reduce Rupture in a Mouse Model of Established Abdominal Aortic Aneurysm.
Owens AP, Edwards TL, Antoniak S, Geddings JE, Jahangir E, Wei WQ, Denny JC, Boulaftali Y, Bergmeier W, Daugherty A, Sampson UKA, Mackman N
(2015) Arterioscler Thromb Vasc Biol 35: 2032-2041
MeSH Terms: Aged, Angiotensin II, Animals, Aorta, Abdominal, Aortic Aneurysm, Abdominal, Aortic Rupture, Disease Models, Animal, Female, Follow-Up Studies, Humans, Infusions, Intravenous, Male, Mice, Mice, Inbred C57BL, Platelet Aggregation Inhibitors
Added February 22, 2016
0 Communities
3 Members
0 Resources
15 MeSH Terms