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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 3 of 3

Publication Record


Oxicams, a class of nonsteroidal anti-inflammatory drugs and beyond.
Xu S, Rouzer CA, Marnett LJ
(2014) IUBMB Life 66: 803-11
MeSH Terms: Anti-Inflammatory Agents, Non-Steroidal, Humans, Inflammation, Intramolecular Oxidoreductases, Meloxicam, Piroxicam, Prostaglandin-E Synthases, Thiazines, Thiazoles
Added February 22, 2016
0 Communities
2 Members
0 Resources
9 MeSH Terms
Oxicams bind in a novel mode to the cyclooxygenase active site via a two-water-mediated H-bonding Network.
Xu S, Hermanson DJ, Banerjee S, Ghebreselasie K, Clayton GM, Garavito RM, Marnett LJ
(2014) J Biol Chem 289: 6799-6808
MeSH Terms: Amino Acid Substitution, Animals, Anti-Inflammatory Agents, Non-Steroidal, Arginine, Binding Sites, Catalytic Domain, Cyclooxygenase 1, Cyclooxygenase 2, Cyclooxygenase Inhibitors, Hydrogen Bonding, Leucine, Meloxicam, Mice, Mutation, Piroxicam, Protein Structure, Secondary, Serine, Thiazines, Thiazoles, Tyrosine, Water
Added March 27, 2014
0 Communities
2 Members
0 Resources
21 MeSH Terms
A novel mechanism of cyclooxygenase-2 inhibition involving interactions with Ser-530 and Tyr-385.
Rowlinson SW, Kiefer JR, Prusakiewicz JJ, Pawlitz JL, Kozak KR, Kalgutkar AS, Stallings WC, Kurumbail RG, Marnett LJ
(2003) J Biol Chem 278: 45763-9
MeSH Terms: Animals, Anti-Inflammatory Agents, Non-Steroidal, Arachidonic Acid, Arginine, Binding, Competitive, Cell Line, Crystallography, X-Ray, Cyclooxygenase 2, Diclofenac, Dose-Response Relationship, Drug, Enzyme Inhibitors, Insecta, Isoenzymes, Mice, Models, Chemical, Models, Molecular, Mutagenesis, Site-Directed, Mutation, Piroxicam, Prostaglandin-Endoperoxide Synthases, Protein Binding, Serine, Sulfonamides, Time Factors, Tyrosine
Added March 5, 2014
0 Communities
1 Members
0 Resources
25 MeSH Terms