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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 68

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Symmetrically substituted dichlorophenes inhibit -acyl-phosphatidylethanolamine phospholipase D.
Aggarwal G, Zarrow JE, Mashhadi Z, Flynn CR, Vinson P, Weaver CD, Davies SS
(2020) J Biol Chem 295: 7289-7300
MeSH Terms: Animals, Bacterial Proteins, Bithionol, Dichlorophen, Enzyme Inhibitors, HEK293 Cells, Hexachlorophene, Humans, Mice, Phospholipase D, Quinazolines, Streptomyces, Sulfonamides
Added August 18, 2020
0 Communities
1 Members
0 Resources
13 MeSH Terms
Biased M receptor-positive allosteric modulators reveal role of phospholipase D in M-dependent rodent cortical plasticity.
Moran SP, Xiang Z, Doyle CA, Maksymetz J, Lv X, Faltin S, Fisher NM, Niswender CM, Rook JM, Lindsley CW, Conn PJ
(2019) Sci Signal 12:
MeSH Terms: Allosteric Site, Animals, CHO Cells, Calcium, Cerebral Cortex, Cognition, Cricetinae, Cricetulus, Electrophysiology, Female, Humans, Long-Term Synaptic Depression, Male, Mice, Mice, Inbred C57BL, Mice, Knockout, Neuronal Plasticity, Phospholipase D, Prefrontal Cortex, Receptor, Muscarinic M1, Signal Transduction, Type C Phospholipases
Added March 3, 2020
0 Communities
2 Members
0 Resources
22 MeSH Terms
Leptogenic effects of NAPE require activity of NAPE-hydrolyzing phospholipase D.
Chen Z, Zhang Y, Guo L, Dosoky N, de Ferra L, Peters S, Niswender KD, Davies SS
(2017) J Lipid Res 58: 1624-1635
MeSH Terms: Animals, Arabidopsis, Hydrolysis, Leptin, Mice, Phosphatidylethanolamines, Phospholipase D
Added April 10, 2018
1 Communities
2 Members
0 Resources
MeSH Terms
Human phospholipase D activity transiently regulates pyrimidine biosynthesis in malignant gliomas.
Mathews TP, Hill S, Rose KL, Ivanova PT, Lindsley CW, Brown HA
(2015) ACS Chem Biol 10: 1258-68
MeSH Terms: Amino Acid Sequence, Brain Neoplasms, Cell Line, Tumor, Enzyme Inhibitors, Glioma, Humans, Molecular Sequence Data, Phospholipase D, Pyrimidines, Signal Transduction, Structure-Activity Relationship, TOR Serine-Threonine Kinases
Added February 12, 2015
0 Communities
1 Members
0 Resources
12 MeSH Terms
Biochemical characterization of a Pseudomonas aeruginosa phospholipase D.
Spencer C, Brown HA
(2015) Biochemistry 54: 1208-18
MeSH Terms: Bacterial Proteins, Cell Line, Humans, Phospholipase D, Pseudomonas aeruginosa, Sequence Homology, Amino Acid, Species Specificity, Substrate Specificity
Added February 12, 2015
0 Communities
1 Members
0 Resources
8 MeSH Terms
Further evaluation of novel structural modifications to scaffolds that engender PLD isoform selective inhibition.
O'Reilly MC, Scott SA, Brown HA, Lindsley CW
(2014) Bioorg Med Chem Lett 24: 5553-5557
MeSH Terms: Animals, Benzimidazoles, Enzyme Inhibitors, HEK293 Cells, Humans, Kinetics, Microsomes, Phospholipase D, Piperidines, Protein Binding, Rats, Structure-Activity Relationship
Added February 12, 2015
0 Communities
1 Members
0 Resources
12 MeSH Terms
Phospholipase D facilitates efficient entry of influenza virus, allowing escape from innate immune inhibition.
Oguin TH, Sharma S, Stuart AD, Duan S, Scott SA, Jones CK, Daniels JS, Lindsley CW, Thomas PG, Brown HA
(2014) J Biol Chem 289: 25405-17
MeSH Terms: Cell Line, Endocytosis, Gene Expression Regulation, Viral, Humans, Immunity, Innate, Influenza A Virus, H1N1 Subtype, Influenza, Human, Orthomyxoviridae, Phospholipase D, Phospholipids, RNA Interference, Virus Internalization, Virus Replication
Added March 18, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
Isolevuglandin-modified phosphatidylethanolamine is metabolized by NAPE-hydrolyzing phospholipase D.
Guo L, Gragg SD, Chen Z, Zhang Y, Amarnath V, Davies SS
(2013) J Lipid Res 54: 3151-7
MeSH Terms: Aldehydes, Animals, Gene Silencing, HEK293 Cells, Humans, Hydrolysis, Mice, Phosphatidylethanolamines, Phospholipase D
Added January 3, 2014
2 Communities
1 Members
0 Resources
9 MeSH Terms
Regulation of phospholipase D activity and phosphatidic acid production after purinergic (P2Y6) receptor stimulation.
Scott SA, Xiang Y, Mathews TP, Cho HP, Myers DS, Armstrong MD, Tallman KA, O'Reilly MC, Lindsley CW, Brown HA
(2013) J Biol Chem 288: 20477-87
MeSH Terms: 1-Butanol, Blotting, Western, Cell Line, Tumor, Diacylglycerol Kinase, Diglycerides, Dose-Response Relationship, Drug, Enzyme Inhibitors, Humans, Hydrolysis, Isoenzymes, Mass Spectrometry, Models, Biological, Phosphatidic Acids, Phosphatidylcholines, Phospholipase C delta, Phospholipase D, Protein Kinase C-alpha, RNA Interference, Receptors, Purinergic P2, Signal Transduction, Uridine Diphosphate
Added March 7, 2014
1 Communities
2 Members
0 Resources
21 MeSH Terms
Development of dual PLD1/2 and PLD2 selective inhibitors from a common 1,3,8-Triazaspiro[4.5]decane Core: discovery of Ml298 and Ml299 that decrease invasive migration in U87-MG glioblastoma cells.
O'Reilly MC, Scott SA, Brown KA, Oguin TH, Thomas PG, Daniels JS, Morrison R, Brown HA, Lindsley CW
(2013) J Med Chem 56: 2695-9
MeSH Terms: Benzamides, Cell Line, Tumor, Cell Movement, Drug Discovery, Enzyme Inhibitors, Glioblastoma, Humans, Neoplasm Invasiveness, Phospholipase D, Spiro Compounds
Added March 19, 2013
1 Communities
2 Members
0 Resources
10 MeSH Terms