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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 29

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Mitochondrial metabolism mediates oxidative stress and inflammation in fatty liver.
Satapati S, Kucejova B, Duarte JA, Fletcher JA, Reynolds L, Sunny NE, He T, Nair LA, Livingston KA, Livingston K, Fu X, Merritt ME, Sherry AD, Malloy CR, Shelton JM, Lambert J, Parks EJ, Corbin I, Magnuson MA, Browning JD, Burgess SC
(2015) J Clin Invest 125: 4447-62
MeSH Terms: Animals, Hepatocytes, Humans, Inflammation, Intracellular Signaling Peptides and Proteins, Mice, Mitochondria, Liver, Non-alcoholic Fatty Liver Disease, Oxidative Stress, Phosphoenolpyruvate Carboxykinase (GTP), Rats, Rats, Wistar
Added January 5, 2016
1 Communities
1 Members
0 Resources
12 MeSH Terms
AS160 deficiency causes whole-body insulin resistance via composite effects in multiple tissues.
Wang HY, Ducommun S, Quan C, Xie B, Li M, Wasserman DH, Sakamoto K, Mackintosh C, Chen S
(2013) Biochem J 449: 479-89
MeSH Terms: Adipocytes, Adipose Tissue, Animals, Blood Glucose, Blotting, Western, Cells, Cultured, Female, GTPase-Activating Proteins, Glucose, Glucose Tolerance Test, Glucose Transporter Type 4, Glycogen Synthase Kinase 3, Humans, Hypoglycemic Agents, In Vitro Techniques, Insulin, Insulin Resistance, Liver, Male, Mice, Mice, Knockout, Muscle, Skeletal, Phosphoenolpyruvate Carboxykinase (GTP), Phosphorylation
Added July 21, 2014
1 Communities
0 Members
0 Resources
24 MeSH Terms
Phosphoenolpyruvate carboxykinase (Pck1) helps regulate the triglyceride/fatty acid cycle and development of insulin resistance in mice.
Millward CA, Desantis D, Hsieh CW, Heaney JD, Pisano S, Olswang Y, Reshef L, Beidelschies M, Puchowicz M, Croniger CM
(2010) J Lipid Res 51: 1452-63
MeSH Terms: Adipose Tissue, White, Animals, Binding Sites, Biological Transport, Fatty Acids, Female, Gene Expression Regulation, Enzymologic, Glucose, Humans, Insulin Resistance, Lipolysis, Liver, Male, Mice, Muscles, PPAR gamma, Phosphoenolpyruvate Carboxykinase (GTP), Promoter Regions, Genetic, RNA, Messenger, Sequence Deletion, Triglycerides
Added July 29, 2015
1 Communities
0 Members
0 Resources
21 MeSH Terms
Hepatic energy state is regulated by glucagon receptor signaling in mice.
Berglund ED, Lee-Young RS, Lustig DG, Lynes SE, Donahue EP, Camacho RC, Meredith ME, Magnuson MA, Charron MJ, Wasserman DH
(2009) J Clin Invest 119: 2412-22
MeSH Terms: Adenosine Diphosphate, Adenosine Monophosphate, Adenosine Triphosphate, Animals, Energy Metabolism, Glucagon, Liver, Male, Mice, Mice, Inbred C57BL, Phosphoenolpyruvate Carboxykinase (GTP), Receptors, Glucagon, Signal Transduction
Added March 18, 2013
3 Communities
1 Members
0 Resources
13 MeSH Terms
Cytosolic phosphoenolpyruvate carboxykinase does not solely control the rate of hepatic gluconeogenesis in the intact mouse liver.
Burgess SC, He T, Yan Z, Lindner J, Sherry AD, Malloy CR, Browning JD, Magnuson MA
(2007) Cell Metab 5: 313-20
MeSH Terms: Animals, Carbon Radioisotopes, Cytosol, Deuterium, Energy Metabolism, Gene Expression Regulation, Enzymologic, Gluconeogenesis, Glucose, In Vitro Techniques, Liver, Mice, Mice, Transgenic, Models, Biological, Phosphoenolpyruvate Carboxykinase (GTP), Phosphoenolpyruvate Carboxylase, Radioactive Tracers
Added April 10, 2012
1 Communities
2 Members
0 Resources
16 MeSH Terms
Renal bone morphogenetic protein-7 protects against diabetic nephropathy.
Wang S, de Caestecker M, Kopp J, Mitu G, Lapage J, Hirschberg R
(2006) J Am Soc Nephrol 17: 2504-12
MeSH Terms: Animals, Bone Morphogenetic Protein 7, Bone Morphogenetic Proteins, Diabetes Mellitus, Experimental, Diabetic Nephropathies, Fibrosis, Humans, Inhibitor of Differentiation Protein 1, Kidney, Male, Mice, Mice, Transgenic, Phosphoenolpyruvate Carboxykinase (GTP), Plasminogen Activator Inhibitor 1, Podocytes, Promoter Regions, Genetic, Smad1 Protein, Smad2 Protein, Smad3 Protein, Smad5 Protein, Transforming Growth Factor beta
Added January 5, 2011
2 Communities
1 Members
0 Resources
21 MeSH Terms
p38 Mitogen-activated protein kinase plays a stimulatory role in hepatic gluconeogenesis.
Cao W, Collins QF, Becker TC, Robidoux J, Lupo EG, Xiong Y, Daniel KW, Floering L, Collins S
(2005) J Biol Chem 280: 42731-7
MeSH Terms: Acetylcysteine, Adenoviridae, Animals, Cell Line, Tumor, Colforsin, Cyclic AMP, Cyclic AMP Response Element-Binding Protein, Cyclic AMP-Dependent Protein Kinases, Diabetes Mellitus, Type 1, Disease Models, Animal, Enzyme Inhibitors, Gene Silencing, Glucagon, Gluconeogenesis, Glucose, Glucose-6-Phosphatase, Hepatocytes, Imidazoles, Liver, Mice, Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha, Phosphoenolpyruvate Carboxykinase (GTP), Phosphorylation, Promoter Regions, Genetic, Pyridines, RNA, Small Interfering, Reverse Transcriptase Polymerase Chain Reaction, Streptozocin, Trans-Activators, Transcription Factors, Transfection, p38 Mitogen-Activated Protein Kinases
Added July 22, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
Impaired tricarboxylic acid cycle activity in mouse livers lacking cytosolic phosphoenolpyruvate carboxykinase.
Burgess SC, Hausler N, Merritt M, Jeffrey FM, Storey C, Milde A, Koshy S, Lindner J, Magnuson MA, Malloy CR, Sherry AD
(2004) J Biol Chem 279: 48941-9
MeSH Terms: Animals, Biochemical Phenomena, Biochemistry, Citric Acid Cycle, Cytosol, Food Deprivation, Glucose, Hydrogen, Kinetics, Liver, Magnetic Resonance Spectroscopy, Mice, Mice, Knockout, Mitochondria, Models, Biological, NAD, Oxidation-Reduction, Oxygen Consumption, Perfusion, Phosphoenolpyruvate Carboxykinase (GTP), Phosphorylation, Time Factors
Added April 10, 2012
1 Communities
2 Members
0 Resources
22 MeSH Terms
Mechanisms by which liver-specific PEPCK knockout mice preserve euglycemia during starvation.
She P, Burgess SC, Shiota M, Flakoll P, Donahue EP, Malloy CR, Sherry AD, Magnuson MA
(2003) Diabetes 52: 1649-54
MeSH Terms: Animals, Blood Glucose, Glucokinase, Glucose, Glycerol, Glycogen Synthase, Homeostasis, Liver, Liver Glycogen, Mice, Mice, Knockout, Muscle, Skeletal, Phosphoenolpyruvate Carboxykinase (GTP), Starvation
Added December 10, 2013
1 Communities
3 Members
0 Resources
14 MeSH Terms
Gene-altered mice and metabolic flux control.
Magnuson MA, She P, Shiota M
(2003) J Biol Chem 278: 32485-8
MeSH Terms: Animals, Gene Expression Regulation, Enzymologic, Glucokinase, Glucose, Homeostasis, Mice, Mice, Knockout, Mice, Transgenic, Phosphoenolpyruvate Carboxykinase (ATP), Phosphoenolpyruvate Carboxykinase (GTP), Tissue Distribution
Added December 10, 2013
1 Communities
3 Members
0 Resources
11 MeSH Terms