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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 5 of 5

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Airway bacteria drive a progressive COPD-like phenotype in mice with polymeric immunoglobulin receptor deficiency.
Richmond BW, Brucker RM, Han W, Du RH, Zhang Y, Cheng DS, Gleaves L, Abdolrasulnia R, Polosukhina D, Clark PE, Bordenstein SR, Blackwell TS, Polosukhin VV
(2016) Nat Commun 7: 11240
MeSH Terms: Aging, Airway Remodeling, Aminopyridines, Animals, Benzamides, Cyclic Nucleotide Phosphodiesterases, Type 4, Cyclopropanes, Disease Models, Animal, Gene Expression Regulation, Host-Pathogen Interactions, Humans, Immunity, Innate, Immunoglobulin A, Secretory, Leukocyte Elastase, Lung, Matrix Metalloproteinase 12, Mice, Mice, Inbred C57BL, Mice, Knockout, Microbiota, NF-kappa B, Phosphodiesterase 4 Inhibitors, Pulmonary Disease, Chronic Obstructive, Pulmonary Emphysema, Receptors, Polymeric Immunoglobulin, Respiratory Mucosa
Added March 30, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
Development of thieno- and benzopyrimidinone inhibitors of the Hedgehog signaling pathway reveals PDE4-dependent and PDE4-independent mechanisms of action.
Hempel JE, Cadar AG, Hong CC
(2016) Bioorg Med Chem Lett 26: 1947-53
MeSH Terms: Cyclic Nucleotide Phosphodiesterases, Type 4, Dose-Response Relationship, Drug, HEK293 Cells, Hedgehog Proteins, Humans, Molecular Structure, Phosphodiesterase 4 Inhibitors, Pyrimidinones, Repressor Proteins, Signal Transduction, Smoothened Receptor, Structure-Activity Relationship
Added March 17, 2016
1 Communities
1 Members
0 Resources
12 MeSH Terms
An in vivo chemical genetic screen identifies phosphodiesterase 4 as a pharmacological target for hedgehog signaling inhibition.
Williams CH, Hempel JE, Hao J, Frist AY, Williams MM, Fleming JT, Sulikowski GA, Cooper MK, Chiang C, Hong CC
(2015) Cell Rep 11: 43-50
MeSH Terms: Animals, Cyclic AMP-Dependent Protein Kinases, Cyclic Nucleotide Phosphodiesterases, Type 4, Hedgehog Proteins, Phosphodiesterase 4 Inhibitors, Pyrimidinones, Receptors, G-Protein-Coupled, Signal Transduction, Small Molecule Libraries, Smoothened Receptor, Thiophenes, Transcriptional Activation, Zebrafish, Zebrafish Proteins
Added April 5, 2015
1 Communities
3 Members
0 Resources
14 MeSH Terms
Biomimetic synthesis and biological evaluation of Aplidiopsamine A.
Panarese JD, Lindsley CW
(2012) Org Lett 14: 5808-10
MeSH Terms: Alkaloids, Animals, Australia, Brain Diseases, Molecular Structure, Phosphodiesterase 4 Inhibitors, Pyrroles, Quinolines, Stereoisomerism, Structure-Activity Relationship, Urochordata
Added March 7, 2014
1 Communities
1 Members
0 Resources
11 MeSH Terms
Inhibition of phosphodiesterase-4 (PDE4) activity triggers luminal apoptosis and AKT dephosphorylation in a 3-D colonic-crypt model.
Tsunoda T, Ota T, Fujimoto T, Doi K, Tanaka Y, Yoshida Y, Ogawa M, Matsuzaki H, Hamabashiri M, Tyson DR, Kuroki M, Miyamoto S, Shirasawa S
(2012) Mol Cancer 11: 46
MeSH Terms: Apoptosis, Cell Line, Tumor, Cluster Analysis, Colorectal Neoplasms, Cyclic Nucleotide Phosphodiesterases, Type 4, Enzyme Activation, Gene Expression Profiling, Gene Expression Regulation, Neoplastic, Genes, ras, HCT116 Cells, Humans, Phosphodiesterase 4 Inhibitors, Phosphorylation, Proto-Oncogene Proteins c-akt, RNA Interference, Recurrence, Rolipram, Spheroids, Cellular, Tight Junctions, Tumor Cells, Cultured
Added February 27, 2013
0 Communities
1 Members
0 Resources
20 MeSH Terms