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Results: 1 to 4 of 4

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Structural analysis of lecithin:cholesterol acyltransferase bound to high density lipoprotein particles.
Manthei KA, Patra D, Wilson CJ, Fawaz MV, Piersimoni L, Shenkar JC, Yuan W, Andrews PC, Engen JR, Schwendeman A, Ohi MD, Tesmer JJG
(2020) Commun Biol 3: 28
MeSH Terms: Binding Sites, Catalytic Domain, Lipoproteins, HDL, Lysine, Mass Spectrometry, Models, Molecular, Multiprotein Complexes, Phosphatidylcholine-Sterol O-Acyltransferase, Protein Binding, Protein Conformation, Recombinant Proteins, Structure-Activity Relationship
Added March 3, 2020
0 Communities
1 Members
0 Resources
12 MeSH Terms
A thumbwheel mechanism for APOA1 activation of LCAT activity in HDL.
Cooke AL, Morris J, Melchior JT, Street SE, Jerome WG, Huang R, Herr AB, Smith LE, Segrest JP, Remaley AT, Shah AS, Thompson TB, Davidson WS
(2018) J Lipid Res 59: 1244-1255
MeSH Terms: Apolipoprotein A-I, Cholesterol, HDL, Enzyme Activation, Humans, Mutation, Phosphatidylcholine-Sterol O-Acyltransferase
Added March 3, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
Low levels of high-density lipoprotein cholesterol due to lecithin:cholesterol acyltransferase mutations increase carotid atherosclerosis.
Fazio S, Linton MF
(2011) J Am Coll Cardiol 58: 2488-90
MeSH Terms: Atherosclerosis, Carotid Arteries, Carotid Artery Diseases, Female, Heterozygote, Humans, Magnetic Resonance Imaging, Male, Mutation, Phosphatidylcholine-Sterol O-Acyltransferase, Ultrasonography
Added December 10, 2013
0 Communities
2 Members
0 Resources
11 MeSH Terms
Hydrolysis of phosphatidylcholine by hepatic lipase in discoidal and spheroidal recombinant high-density lipoprotein.
Tansey JT, Thuren TY, Jerome WG, Hantgan RR, Grant K, Waite M
(1997) Biochemistry 36: 12227-34
MeSH Terms: Apolipoprotein A-I, Cholesterol Esters, Humans, Hydrolysis, Lasers, Lipase, Lipoproteins, HDL, Liver, Microscopy, Electron, Particle Size, Phosphatidylcholine-Sterol O-Acyltransferase, Phosphatidylcholines, Protein Conformation, Recombinant Proteins, Scattering, Radiation, Substrate Specificity
Added December 10, 2013
0 Communities
1 Members
0 Resources
16 MeSH Terms