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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 32

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Analgesic Effects of the GIRK Activator, VU0466551, Alone and in Combination with Morphine in Acute and Persistent Pain Models.
Abney KK, Bubser M, Du Y, Kozek KA, Bridges TM, Linsdley CW, Daniels JS, Morrison RD, Wickman K, Hopkins CR, Jones CK, Weaver CD
(2019) ACS Chem Neurosci 10: 1294-1299
MeSH Terms: Analgesics, Animals, Disease Models, Animal, Dose-Response Relationship, Drug, Drug Therapy, Combination, Formaldehyde, G Protein-Coupled Inwardly-Rectifying Potassium Channels, HEK293 Cells, Hot Temperature, Humans, Male, Mice, Inbred C57BL, Morphine, Pain, Phenylurea Compounds, Pyrazoles
Added April 10, 2019
0 Communities
2 Members
0 Resources
16 MeSH Terms
Structural basis of ligand binding modes at the neuropeptide Y Y receptor.
Yang Z, Han S, Keller M, Kaiser A, Bender BJ, Bosse M, Burkert K, Kögler LM, Wifling D, Bernhardt G, Plank N, Littmann T, Schmidt P, Yi C, Li B, Ye S, Zhang R, Xu B, Larhammar D, Stevens RC, Huster D, Meiler J, Zhao Q, Beck-Sickinger AG, Buschauer A, Wu B
(2018) Nature 556: 520-524
MeSH Terms: Arginine, Binding Sites, Crystallography, X-Ray, Dihydropyridines, Diphenylacetic Acids, Humans, Inositol Phosphates, Ligands, Molecular Docking Simulation, Mutant Proteins, Mutation, Neuropeptide Y, Nuclear Magnetic Resonance, Biomolecular, Phenylurea Compounds, Protein Binding, Receptors, Neuropeptide Y, Structure-Activity Relationship, Substrate Specificity
Added March 21, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
FGFR1 signaling in hypertrophic chondrocytes is attenuated by the Ras-GAP neurofibromin during endochondral bone formation.
Karolak MR, Yang X, Elefteriou F
(2015) Hum Mol Genet 24: 2552-64
MeSH Terms: Animals, Chondrocytes, Chondrogenesis, Collagen Type II, Female, Gene Expression, Gene Knockout Techniques, Growth Plate, Hypertrophy, Male, Mice, Mice, Knockout, Neurofibromin 1, Osteoclasts, Osteogenesis, Phenotype, Phenylurea Compounds, Protein Transport, Pyrimidines, Receptor, Fibroblast Growth Factor, Type 1, Receptor, Fibroblast Growth Factor, Type 3, Signal Transduction
Added February 19, 2015
0 Communities
1 Members
0 Resources
22 MeSH Terms
A randomized phase II efficacy and correlative studies of cetuximab with or without sorafenib in recurrent and/or metastatic head and neck squamous cell carcinoma.
Gilbert J, Schell MJ, Zhao X, Murphy B, Tanvetyanon T, Leon ME, Neil Hayes D, Haigentz M, Saba N, Nieva J, Bishop J, Sidransky D, Ravi R, Bedi A, Chung CH
(2015) Oral Oncol 51: 376-82
MeSH Terms: Adult, Aged, Antineoplastic Agents, Carcinoma, Squamous Cell, Cetuximab, Female, Head and Neck Neoplasms, Humans, Male, Middle Aged, Neoplasm Metastasis, Niacinamide, Phenylurea Compounds, Recurrence, Sorafenib
Added February 17, 2015
0 Communities
1 Members
0 Resources
15 MeSH Terms
Discovery of potent and selective GIRK1/2 modulators via 'molecular switches' within a series of 1-(3-cyclopropyl-1-phenyl-1H-pyrazol-5-yl)ureas.
Wen W, Wu W, Weaver CD, Lindsley CW
(2014) Bioorg Med Chem Lett 24: 5102-6
MeSH Terms: Animals, Drug Evaluation, Preclinical, G Protein-Coupled Inwardly-Rectifying Potassium Channels, Microsomes, Phenylurea Compounds, Protein Binding, Pyrazoles, Rats, Structure-Activity Relationship, Urea
Added February 16, 2015
0 Communities
1 Members
0 Resources
10 MeSH Terms
Mechanisms underlying the activation of G-protein-gated inwardly rectifying K+ (GIRK) channels by the novel anxiolytic drug, ML297.
Wydeven N, Marron Fernandez de Velasco E, Du Y, Benneyworth MA, Hearing MC, Fischer RA, Thomas MJ, Weaver CD, Wickman K
(2014) Proc Natl Acad Sci U S A 111: 10755-60
MeSH Terms: Amino Acid Sequence, Animals, Anti-Anxiety Agents, Baclofen, Behavior, Animal, G Protein-Coupled Inwardly-Rectifying Potassium Channels, Hippocampus, Ion Channel Gating, Mice, Mice, Inbred C57BL, Molecular Sequence Data, Neurons, Phenylurea Compounds, Pyrazoles
Added February 16, 2015
0 Communities
1 Members
0 Resources
14 MeSH Terms
Phase II trial of sorafenib and erlotinib in advanced pancreatic cancer.
Cardin DB, Goff L, Li CI, Shyr Y, Winkler C, DeVore R, Schlabach L, Holloway M, McClanahan P, Meyer K, Grigorieva J, Berlin J, Chan E
(2014) Cancer Med 3: 572-9
MeSH Terms: Adult, Aged, Aged, 80 and over, Antineoplastic Combined Chemotherapy Protocols, Disease-Free Survival, Drug-Related Side Effects and Adverse Reactions, ErbB Receptors, Erlotinib Hydrochloride, Female, Humans, Male, Middle Aged, Molecular Targeted Therapy, Neoplasm Staging, Niacinamide, Pancreatic Neoplasms, Phenylurea Compounds, Quinazolines, Sorafenib
Added March 11, 2014
0 Communities
5 Members
0 Resources
19 MeSH Terms
Oncogenic and sorafenib-sensitive ARAF mutations in lung adenocarcinoma.
Imielinski M, Greulich H, Kaplan B, Araujo L, Amann J, Horn L, Schiller J, Villalona-Calero MA, Meyerson M, Carbone DP
(2014) J Clin Invest 124: 1582-6
MeSH Terms: Adenocarcinoma, Adenocarcinoma of Lung, Aged, Amino Acid Substitution, Antineoplastic Agents, Cell Transformation, Neoplastic, DNA, Neoplasm, Female, Humans, Lung Neoplasms, Molecular Targeted Therapy, Mutation, Missense, Niacinamide, Oncogenes, Phenylurea Compounds, Proto-Oncogene Proteins A-raf, Proto-Oncogene Proteins B-raf, Proto-Oncogene Proteins c-raf, Sorafenib
Added June 26, 2014
0 Communities
1 Members
0 Resources
19 MeSH Terms
ML297 (VU0456810), the first potent and selective activator of the GIRK potassium channel, displays antiepileptic properties in mice.
Kaufmann K, Romaine I, Days E, Pascual C, Malik A, Yang L, Zou B, Du Y, Sliwoski G, Morrison RD, Denton J, Niswender CM, Daniels JS, Sulikowski GA, Xie XS, Lindsley CW, Weaver CD
(2013) ACS Chem Neurosci 4: 1278-86
MeSH Terms: Animals, Anticonvulsants, Calcium Signaling, Dose-Response Relationship, Drug, Drug Evaluation, Preclinical, Electroshock, G Protein-Coupled Inwardly-Rectifying Potassium Channels, HEK293 Cells, High-Throughput Screening Assays, Humans, Injections, Intraperitoneal, Mice, Microsomes, Liver, Molecular Structure, Patch-Clamp Techniques, Pentylenetetrazole, Phenylurea Compounds, Pyrazoles, Rats, Receptors, Metabotropic Glutamate, Recombinant Proteins, Seizures, Valproic Acid
Added February 16, 2015
0 Communities
2 Members
0 Resources
23 MeSH Terms
Substituted 1-Phenyl-3-(pyridin-2-yl)urea negative allosteric modulators of mGlu5: discovery of a new tool compound VU0463841 with activity in rat models of cocaine addiction.
Amato RJ, Felts AS, Rodriguez AL, Venable DF, Morrison RD, Byers FW, Daniels JS, Niswender CM, Conn PJ, Lindsley CW, Jones CK, Emmitte KA
(2013) ACS Chem Neurosci 4: 1217-28
MeSH Terms: Allosteric Regulation, Aminopyridines, Animals, Brain, Cocaine-Related Disorders, Disease Models, Animal, Liver, Phenylurea Compounds, Rats, Receptor, Metabotropic Glutamate 5, Structure-Activity Relationship, Urea
Added February 19, 2015
0 Communities
3 Members
0 Resources
12 MeSH Terms