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TGF-β promotes fibrosis after severe acute kidney injury by enhancing renal macrophage infiltration.
Chung S, Overstreet JM, Li Y, Wang Y, Niu A, Wang S, Fan X, Sasaki K, Jin GN, Khodo SN, Gewin L, Zhang MZ, Harris RC
(2018) JCI Insight 3:
MeSH Terms: Acute Kidney Injury, Animals, Bone Marrow Cells, Chemotactic Factors, Fibrosis, Kidney, Macrophages, Male, Mice, Mice, Transgenic, Monocytes, N-Formylmethionine Leucyl-Phenylalanine, Receptor, Transforming Growth Factor-beta Type II, Receptors, Transforming Growth Factor beta, Transforming Growth Factor beta, Transforming Growth Factor beta1
Added December 26, 2018
0 Communities
2 Members
0 Resources
16 MeSH Terms
D-amino acid inhibits biofilm but not new bone formation in an ovine model.
Harmata AJ, Ma Y, Sanchez CJ, Zienkiewicz KJ, Elefteriou F, Wenke JC, Guelcher SA
(2015) Clin Orthop Relat Res 473: 3951-61
MeSH Terms: Amino Acids, Animals, Anti-Bacterial Agents, Biofilms, Biomarkers, Bone Transplantation, Cell Differentiation, Cell Proliferation, Cells, Cultured, Dose-Response Relationship, Drug, Female, Femur, Mesenchymal Stem Cells, Methicillin-Resistant Staphylococcus aureus, Methionine, Mice, Models, Animal, Osseointegration, Osteoblasts, Osteoclasts, Osteogenesis, Phenylalanine, Proline, Sheep, Domestic, Time Factors, X-Ray Microtomography
Added May 16, 2017
1 Communities
1 Members
0 Resources
26 MeSH Terms
HIV-1 Resistance to the Capsid-Targeting Inhibitor PF74 Results in Altered Dependence on Host Factors Required for Virus Nuclear Entry.
Zhou J, Price AJ, Halambage UD, James LC, Aiken C
(2015) J Virol 89: 9068-79
MeSH Terms: Amino Acid Substitution, Anti-HIV Agents, Binding Sites, CD4-Positive T-Lymphocytes, Capsid, Capsid Proteins, Cell Line, Drug Resistance, Viral, HIV Infections, HIV-1, Host-Pathogen Interactions, Humans, Indoles, Macrophages, Molecular Chaperones, Nuclear Pore Complex Proteins, Phenylalanine, Protein Binding, Protein Conformation, RNA Interference, RNA, Small Interfering, Virus Internalization, Virus Replication, beta Karyopherins, mRNA Cleavage and Polyadenylation Factors
Added February 4, 2016
0 Communities
1 Members
0 Resources
25 MeSH Terms
Compensatory substitutions in the HIV-1 capsid reduce the fitness cost associated with resistance to a capsid-targeting small-molecule inhibitor.
Shi J, Zhou J, Halambage UD, Shah VB, Burse MJ, Wu H, Blair WS, Butler SL, Aiken C
(2015) J Virol 89: 208-19
MeSH Terms: Amino Acid Substitution, Anti-HIV Agents, Cells, Cultured, Drug Resistance, Viral, HIV Core Protein p24, HIV-1, Humans, Indoles, Macrophages, Mutant Proteins, Mutation, Missense, Phenylalanine, Selection, Genetic, Suppression, Genetic, Virus Replication
Added February 19, 2015
0 Communities
1 Members
0 Resources
15 MeSH Terms
A conserved phenylalanine as a relay between the α5 helix and the GDP binding region of heterotrimeric Gi protein α subunit.
Kaya AI, Lokits AD, Gilbert JA, Iverson TM, Meiler J, Hamm HE
(2014) J Biol Chem 289: 24475-87
MeSH Terms: Crystallography, X-Ray, GTP-Binding Protein alpha Subunits, Guanosine Diphosphate, Models, Molecular, Phenylalanine, Protein Conformation
Added January 20, 2015
1 Communities
2 Members
0 Resources
6 MeSH Terms
Role of epoxyeicosatrienoic acids (EETs) in mediation of dopamine's effects in the kidney.
Zhang MZ, Wang Y, Yao B, Gewin L, Wei S, Capdevila JH, Harris RC
(2013) Am J Physiol Renal Physiol 305: F1680-6
MeSH Terms: Animals, Arachidonic Acid, Aromatic-L-Amino-Acid Decarboxylases, Catechol O-Methyltransferase, Cells, Cultured, Cytochrome P-450 CYP2J2, Cytochrome P-450 Enzyme System, Cytochrome P450 Family 2, Diet, Sodium-Restricted, Dihydroxyphenylalanine, Disease Models, Animal, Diuresis, Dopamine, Dopamine Agents, Hypertension, Kidney, Male, Mice, Mice, Knockout, Natriuresis, Sodium Chloride, Dietary
Added February 26, 2014
1 Communities
4 Members
0 Resources
21 MeSH Terms
Investigating association of four gene regions (GABRB3, MAOB, PAH, and SLC6A4) with five symptoms in schizophrenia.
Sun J, Jayathilake K, Zhao Z, Meltzer HY
(2012) Psychiatry Res 198: 202-6
MeSH Terms: Delusions, Female, Genetic Association Studies, Genetic Predisposition to Disease, Hallucinations, Haplotypes, Humans, Male, Monoamine Oxidase, Phenylalanine Hydroxylase, Polymorphism, Single Nucleotide, Receptors, GABA-A, Schizophrenia, Serotonin Plasma Membrane Transport Proteins
Added March 5, 2014
0 Communities
1 Members
0 Resources
14 MeSH Terms
A critical phenylalanine residue in the respiratory syncytial virus fusion protein cytoplasmic tail mediates assembly of internal viral proteins into viral filaments and particles.
Shaikh FY, Cox RG, Lifland AW, Hotard AL, Williams JV, Moore ML, Santangelo PJ, Crowe JE
(2012) mBio 3:
MeSH Terms: Amino Acid Sequence, Cell Line, Cell Membrane, Cytoplasm, Cytoskeleton, Humans, Molecular Sequence Data, Mutagenesis, Site-Directed, Phenylalanine, Point Mutation, RNA, Viral, Recombinant Proteins, Respiratory Syncytial Virus Infections, Respiratory Syncytial Virus, Human, Sequence Alignment, Viral Fusion Proteins, Virus Assembly
Added August 6, 2012
0 Communities
1 Members
0 Resources
17 MeSH Terms
Activated factor XI inhibits chemotaxis of polymorphonuclear leukocytes.
Itakura A, Verbout NG, Phillips KG, Insall RH, Gailani D, Tucker EI, Gruber A, McCarty OJ
(2011) J Leukoc Biol 90: 923-7
MeSH Terms: Blood Coagulation, Cell Movement, Cells, Cultured, Chemotaxis, Leukocyte, Factor XIa, Humans, Inflammation, Interleukin-8, N-Formylmethionine Leucyl-Phenylalanine, Neutrophils, Peritonitis, Protein Binding
Added May 19, 2014
0 Communities
1 Members
0 Resources
12 MeSH Terms
Small-molecule inhibition of human immunodeficiency virus type 1 infection by virus capsid destabilization.
Shi J, Zhou J, Shah VB, Aiken C, Whitby K
(2011) J Virol 85: 542-9
MeSH Terms: Animals, Anti-HIV Agents, Capsid, Capsid Proteins, Cell Line, Cyclophilin A, HIV-1, HeLa Cells, Humans, Indoles, Phenylalanine, Reverse Transcription, Virion, Virus Assembly
Added February 19, 2015
0 Communities
1 Members
0 Resources
14 MeSH Terms