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Results: 1 to 10 of 97

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An orthogonal methods assessment of topical drug concentrations in skin and the impact for risk assessment in the viable epidermis.
Hollingshead BD, Tomlinson L, Finley J, Doshna C, Ritenour C, Barricklow J, Oppenheimer SR, O'Neil SP, Moore JL, Patterson NH, Nicholson SP, Norris JL, Caprioli RM, Beaumont K, King-Ahmad AJ, Vispute S, Cook JC, Radi Z, Schuler M
(2021) Regul Toxicol Pharmacol 123: 104934
MeSH Terms: Animals, Epidermis, Humans, Mass Spectrometry, Pharmaceutical Preparations, Risk Assessment, Skin, Skin Absorption, Swine, Swine, Miniature
Added November 20, 2021
0 Communities
1 Members
0 Resources
10 MeSH Terms
The Clinically Approved Antifungal Drug Posaconazole Inhibits Human Cytomegalovirus Replication.
Mercorelli B, Luganini A, Celegato M, Palรน G, Gribaudo G, Lepesheva GI, Loregian A
(2020) Antimicrob Agents Chemother 64:
MeSH Terms: Antifungal Agents, Antiviral Agents, Cytomegalovirus, Cytomegalovirus Infections, Ganciclovir, Humans, Pharmaceutical Preparations, Triazoles, Virus Replication
Added July 2, 2021
0 Communities
1 Members
0 Resources
MeSH Terms
In Vitro Activation of Cytochrome P450 46A1 (CYP46A1) by Efavirenz-Related Compounds.
Mast N, Verwilst P, Wilkey CJ, Guengerich FP, Pikuleva IA
(2020) J Med Chem 63: 6477-6488
MeSH Terms: Alkynes, Allosteric Site, Benzoxazines, Catalytic Domain, Cholesterol, Cholesterol 24-Hydroxylase, Cyclopropanes, Cytochrome P-450 CYP3A Inducers, Humans, Hydroxylation, In Vitro Techniques, Pharmaceutical Preparations, Protein Conformation
Added March 3, 2020
0 Communities
1 Members
0 Resources
13 MeSH Terms
Drug Metabolism and Toxicology Special Issue Call for Papers.
Guengerich FP, Georg GI, Wang S
(2019) J Med Chem 62: 1077
MeSH Terms: Humans, Pharmaceutical Preparations, Publishing, Toxicology
Added March 3, 2020
0 Communities
1 Members
0 Resources
4 MeSH Terms
Isomeric and Conformational Analysis of Small Drug and Drug-Like Molecules by Ion Mobility-Mass Spectrometry (IM-MS).
Phillips ST, Dodds JN, May JC, McLean JA
(2019) Methods Mol Biol 1939: 161-178
MeSH Terms: Algorithms, Amino Acids, Carbohydrates, Ion Mobility Spectrometry, Isomerism, Mass Spectrometry, Molecular Conformation, Pharmaceutical Preparations, Small Molecule Libraries, Software
Added August 7, 2019
1 Communities
0 Members
0 Resources
MeSH Terms
Macrophage-Targeted Therapeutics for Metabolic Disease.
Peterson KR, Cottam MA, Kennedy AJ, Hasty AH
(2018) Trends Pharmacol Sci 39: 536-546
MeSH Terms: Drug Delivery Systems, Gene Expression, Humans, Macrophages, Metabolic Diseases, Molecular Targeted Therapy, Pharmaceutical Preparations
Added March 26, 2019
0 Communities
1 Members
0 Resources
MeSH Terms
Sulfenylation of Human Liver and Kidney Microsomal Cytochromes P450 and Other Drug-Metabolizing Enzymes as a Response to Redox Alteration.
Albertolle ME, Phan TTN, Pozzi A, Guengerich FP
(2018) Mol Cell Proteomics 17: 889-900
MeSH Terms: Animals, Biocatalysis, Cysteine, Cytochrome P-450 Enzyme System, Humans, Hydrogen Peroxide, Kidney, Mice, Transgenic, Microsomes, Liver, Oxidation-Reduction, Pharmaceutical Preparations, Recombinant Proteins, Staining and Labeling, Sulfenic Acids, Sulfhydryl Compounds
Added March 14, 2018
1 Communities
1 Members
0 Resources
15 MeSH Terms
Does Secretory Clearance Follow Glomerular Filtration Rate in Chronic Kidney Diseases? Reconsidering the Intact Nephron Hypothesis.
Chapron A, Shen DD, Kestenbaum BR, Robinson-Cohen C, Himmelfarb J, Yeung CK
(2017) Clin Transl Sci 10: 395-403
MeSH Terms: Glomerular Filtration Rate, Humans, Models, Biological, Nephrons, Pharmaceutical Preparations, Renal Insufficiency, Chronic
Added September 19, 2017
0 Communities
1 Members
0 Resources
6 MeSH Terms
Intersection of the Roles of Cytochrome P450 Enzymes with Xenobiotic and Endogenous Substrates: Relevance to Toxicity and Drug Interactions.
Guengerich FP
(2017) Chem Res Toxicol 30: 2-12
MeSH Terms: Animals, Cytochrome P-450 Enzyme System, Drug Interactions, Humans, Pharmaceutical Preparations, Xenobiotics
Added March 14, 2018
0 Communities
1 Members
0 Resources
6 MeSH Terms
Recent Structural Insights into Cytochrome P450 Function.
Guengerich FP, Waterman MR, Egli M
(2016) Trends Pharmacol Sci 37: 625-640
MeSH Terms: Cytochrome P-450 Enzyme System, Humans, Models, Molecular, Pharmaceutical Preparations, Pharmacokinetics, Structure-Activity Relationship
Added March 14, 2018
0 Communities
1 Members
0 Resources
6 MeSH Terms