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Results: 1 to 10 of 22

Publication Record


Ventral striatal dopamine transporter availability is associated with lower trait motor impulsivity in healthy adults.
Smith CT, San Juan MD, Dang LC, Katz DT, Perkins SF, Burgess LL, Cowan RL, Manning HC, Nickels ML, Claassen DO, Samanez-Larkin GR, Zald DH
(2018) Transl Psychiatry 8: 269
MeSH Terms: Adult, Aged, Dopamine Plasma Membrane Transport Proteins, Exploratory Behavior, Female, Fluorodeoxyglucose F18, Humans, Impulsive Behavior, Male, Middle Aged, Personality, Personality Inventory, Positron-Emission Tomography, Ventral Striatum, Young Adult
Show Abstract · Added April 15, 2019
Impulsivity is a transdiagnostic feature of a range of externalizing psychiatric disorders. Preclinical work links reduced ventral striatal dopamine transporter (DAT) availability with heightened impulsivity and novelty seeking. However, there is a lack of human data investigating the relationship between DAT availability, particularly in subregions of the striatum, and the personality traits of impulsivity and novelty seeking. Here we collected PET measures of DAT availability (BP) using the tracer F-FE-PE2I in 47 healthy adult subjects and examined relations between BP in striatum, including its subregions: caudate, putamen, and ventral striatum (VS), and trait impulsivity (Barratt Impulsiveness Scale: BIS-11) and novelty seeking (Tridimensional Personality Questionnaire: TPQ-NS), controlling for age and sex. DAT BP in each striatal subregion showed nominal negative associations with total BIS-11 but not TPQ-NS. At the subscale level, VS DAT BP was significantly associated with BIS-11 motor impulsivity (e.g., taking actions without thinking) after correction for multiple comparisons. VS DAT BP explained 13.2% of the variance in motor impulsivity. Our data demonstrate that DAT availability in VS is negatively related to impulsivity and suggest a particular influence of DAT regulation of dopamine signaling in VS on acting without deliberation (BIS motor impulsivity). While needing replication, these data converge with models of ventral striatal functions that emphasize its role as a key interface linking motivation to action.
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15 MeSH Terms
Personality traits predicting quality of life and overall functioning in schizophrenia.
Ridgewell C, Blackford JU, McHugo M, Heckers S
(2017) Schizophr Res 182: 19-23
MeSH Terms: Adolescent, Adult, Aged, Analysis of Variance, Extraversion, Psychological, Female, Humans, Male, Middle Aged, Neuroticism, Personality Disorders, Personality Inventory, Quality of Life, Schizophrenia, Schizophrenic Psychology, Surveys and Questionnaires, Young Adult
Show Abstract · Added March 30, 2020
INTRODUCTION - Clinical symptoms and sociodemographic variables predict level of functioning and quality of life in patients with schizophrenia. However, few studies have examined the effect of personality traits on quality of life and overall functioning in schizophrenia. Personality traits are premorbid to illness and may predict the way patients experience schizophrenia. The aim of this study was to examine the individual and additive effects of two core personality traits-neuroticism and extraversion-on quality of life and functioning.
METHODS - Patients with schizophrenia-spectrum disorders (n=153) and healthy controls (n=125) completed personality and quality of life questionnaires. Global functioning was assessed during a clinician-administered structured interview. Neuroticism and extraversion scores were analyzed both as continuous variables and as categorical extremes (High versus Normal Neuroticism, Low versus Normal Extraversion).
RESULTS - Quality of life was significantly associated with neuroticism, extraversion, and the neuroticism×diagnosis and extraversion×diagnosis interactions. For patients, a lower neuroticism score (in the normal range) was associated with quality of life scores comparable to controls; whereas high neuroticism scores in patients were associated with the lowest quality of life. For overall functioning, only diagnosis had a significant effect.
CONCLUSION - Neuroticism modulates quality of life and may provide an important key to improving the life of patients with schizophrenia.
Copyright © 2016 Elsevier B.V. All rights reserved.
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MeSH Terms
Treatment course with antidepressant therapy in late-life depression.
Sheline YI, Disabato BM, Hranilovich J, Morris C, D'Angelo G, Pieper C, Toffanin T, Taylor WD, MacFall JR, Wilkins C, Barch DM, Welsh-Bohmer KA, Steffens DC, Krishnan RR, Doraiswamy PM
(2012) Am J Psychiatry 169: 1185-93
MeSH Terms: Aged, Amygdala, Antidepressive Agents, Brain, Caudate Nucleus, Cerebral Cortex, Cognition Disorders, Depressive Disorder, Major, Female, Frontal Lobe, Hippocampus, Humans, Image Interpretation, Computer-Assisted, Magnetic Resonance Imaging, Male, Middle Aged, Neural Pathways, Neuropsychological Tests, Organ Size, Parahippocampal Gyrus, Personality Inventory, Prospective Studies, Psychometrics, Reaction Time, Sertraline, Treatment Outcome
Show Abstract · Added May 20, 2014
OBJECTIVE - In order to assess the effect of gray matter volumes and cortical thickness on antidepressant treatment response in late-life depression, the authors examined the relationship between brain regions identified a priori and Montgomery-Åsberg Depression Rating Scale (MADRS) scores over the course of an antidepressant treatment trial.
METHOD - In a nonrandomized prospective trial, 168 patients who were at least 60 years of age and met DSM-IV criteria for major depression underwent MRI and were enrolled in a 12-week treatment study. Exclusion criteria included cognitive impairment or severe medical disorders. The volumes or cortical thicknesses of regions of interest that differed between the depressed group and a comparison group (N=50) were determined. These regions of interest were used in analyses of the depressed group to predict antidepressant treatment outcome. Mixed-model analyses adjusting for age, education, age at depression onset, race, baseline MADRS score, scanner, and interaction with time examined predictors of MADRS scores over time.
RESULTS - Smaller hippocampal volumes predicted a slower response to treatment. With the inclusion of white matter hyper-intensity severity and neuropsychological factor scores, the best model included hippocampal volume and cognitive processing speed to predict rate of response over time. A secondary analysis showed that hippocampal volume and frontal pole thickness differed between patients who achieved remission and those who did not.
CONCLUSIONS - These data expand our understanding of the prediction of treatment course in late-life depression. The authors propose that the primary variables of hippocampal volume and cognitive processing speed, subsuming other contributing variables (episodic memory, executive function, language processing) predict antidepressant response.
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26 MeSH Terms
Association of five-factor model personality domains and facets with presence, onset, and treatment outcomes of major depression in older adults.
Hayward RD, Taylor WD, Smoski MJ, Steffens DC, Payne ME
(2013) Am J Geriatr Psychiatry 21: 88-96
MeSH Terms: Age of Onset, Aged, Depressive Disorder, Major, Female, Humans, Longitudinal Studies, Male, Models, Psychological, Personality, Personality Inventory, Retrospective Studies, Severity of Illness Index, Treatment Outcome
Show Abstract · Added May 20, 2014
OBJECTIVES - To assess the relationship of multiple domains and facets of the five-factor model of personality with presence, onset, and severity of late-life depression.
DESIGN - Cross-sectional analysis of depression status, and age of onset. Retrospective analysis of baseline severity. Longitudinal analysis of severity after 3 and 12 months of psychiatric treatment.
SETTING - Private university-affiliated medical center in the Southeastern United States.
PARTICIPANTS - One hundred twelve psychiatric patients with a current episode of unipolar major depression, and 104 nondepressed comparison subjects, age 60 and older (mean: 70, SD: 6).
MEASUREMENTS - Revised NEO Personality Inventory, Diagnostic Interview Schedule, and Montgomery-Åsberg Depression Rating Scale.
RESULTS - Binary logistic regression found that depression was related to higher neuroticism (and all its facets) and to lower extraversion (and facets of assertiveness, activity, and positive emotionality) and conscientiousness (and facets of competence, order, dutifulness, and self-discipline). Multinomial logistic regression found some of these relationships held only for depression with onset before age 50 (hostility, self-consciousness, extraversion, assertiveness, positive emotions, order, and dutifulness). Linear regression found that personality was unrelated to depression severity at the beginning of treatment, but improvement after 3 months was related to lower neuroticism (and facets depressiveness and stress-vulnerability) and higher warmth and competence. Improvement after 12 months was related to lower neuroticism, depressiveness, and stress-vulnerability.
CONCLUSIONS - Specific personality facets are related with depression and treatment outcomes. Screening for certain personality traits at the start of treatment may help identify patients at risk of worse response to treatment after 3 months.
Copyright © 2013 American Association for Geriatric Psychiatry. Published by Elsevier Inc. All rights reserved.
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13 MeSH Terms
Interacting effects of trait anger and acute anger arousal on pain: the role of endogenous opioids.
Bruehl S, Burns JW, Chung OY, Chont M
(2011) Psychosom Med 73: 612-9
MeSH Terms: Adult, Anger, Arousal, Cross-Over Studies, Double-Blind Method, Female, Humans, Low Back Pain, Male, Naloxone, Narcotic Antagonists, Opioid Peptides, Pain, Pain Measurement, Personality Inventory
Show Abstract · Added March 5, 2014
OBJECTIVE - Elevated trait anger (TRANG; heightened propensity to experience anger) is associated with greater pain responsiveness, possibly via associations with deficient endogenous opioid analgesia. This study tested whether acute anger arousal moderates the impact of TRANG on endogenous opioid analgesia.
METHODS - Ninety-four chronic low back pain (LBP) participants and 85 healthy controls received opioid blockade (8 mg of naloxone) or placebo in a randomized, counterbalanced order in separate sessions. Participants were randomly assigned to undergo either a 5-minute anger recall interview (ARI) or a neutral control interview across both drug conditions. Immediately after the assigned interview, participants engaged sequentially in finger pressure and ischemic forearm pain tasks. Opioid blockade effects were derived (blockade minus placebo condition pain ratings) to index opioid antinociceptive function.
RESULTS - Placebo condition TRANG by interview interactions (p values < .05) indicated that TRANG was hyperalgesic only in the context of acute anger arousal (ARI condition; p values < .05). Blockade effect analyses suggested that these hyperalgesic effects were related to deficient opioid analgesia. Significant TRANG by interview interactions (p values < .05) for both pain tasks indicated that elevated TRANG was associated with smaller blockade effects (less endogenous opioid analgesia) only in the ARI condition (p values < .05). Results for ischemic task visual analog scale intensity blockade effects suggested that associations between TRANG and impaired opioid function were most evident in LBP participants when experiencing anger (type by interview by TRANG interaction; p < .05).
CONCLUSIONS - Results indicate that hyperalgesic effects of TRANG are most prominent when acute anger is aroused and suggest that endogenous opioid mechanisms contribute.
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15 MeSH Terms
Correlation of individual differences in schizotypal personality traits with amphetamine-induced dopamine release in striatal and extrastriatal brain regions.
Woodward ND, Cowan RL, Park S, Ansari MS, Baldwin RM, Li R, Doop M, Kessler RM, Zald DH
(2011) Am J Psychiatry 168: 418-26
MeSH Terms: Adult, Amphetamine, Brain, Corpus Striatum, Dopamine, Female, Frontal Lobe, Humans, Individuality, Male, Personality Inventory, Positron-Emission Tomography, Schizotypal Personality Disorder, Single-Blind Method, Temporal Lobe, Thalamus, Young Adult
Show Abstract · Added May 27, 2014
OBJECTIVE - Schizotypal personality traits are associated with schizophrenia spectrum disorders, and individuals with schizophrenia spectrum disorders demonstrate increased dopamine transmission in the striatum. The authors sought to determine whether individual differences in normal variation in schizotypal traits are correlated with dopamine transmission in the striatum and in extrastriatal brain regions.
METHOD - Sixty-three healthy volunteers with no history of psychiatric illness completed the Schizotypal Personality Questionnaire and underwent positron emission tomography imaging with [(18)F]fallypride at baseline and after administration of oral d-amphetamine (0.43 mg/kg). Dopamine release, quantified by subtracting each participant's d-amphetamine scan from his or her baseline scan, was correlated with Schizotypal Personality Questionnaire total and factor scores using region-of-interest and voxel-wise analyses.
RESULTS - Dopamine release in the striatum was positively correlated with overall schizotypal traits. The association was especially robust in the associative subdivision of the striatum. Voxel-wise analyses identified additional correlations between dopamine release and schizotypal traits in the left middle frontal gyrus and left supramarginal gyrus. Exploratory analyses of Schizotypal Personality Questionnaire factor scores revealed correlations between dopamine release and disorganized schizotypal traits in the striatum, thalamus, medial prefrontal cortex, temporal lobe, insula, and inferior frontal cortex.
CONCLUSIONS - The association between dopamine signaling and psychosis phenotypes extends to individual differences in normal variation in schizotypal traits and involves dopamine transmission in both striatal and extrastriatal brain regions. Amphetamine-induced dopamine release may be a useful endophenotype for investigating the genetic basis of schizophrenia spectrum disorders.
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17 MeSH Terms
The Perceived Medical Condition Self-Management Scale applied to persons with HIV/AIDS.
Wallston KA, Osborn CY, Wagner LJ, Hilker KA
(2011) J Health Psychol 16: 109-15
MeSH Terms: Adult, Female, HIV Infections, Humans, Male, Personality Inventory, Psychometrics, Reproducibility of Results, Self Efficacy
Show Abstract · Added December 10, 2013
The Perceived Medical Condition Self-Management Scale (PMCSMS), a generic instrument developed to assess self-management self-efficacy in specific medical conditions, was tailored for use with HIV+ individuals and administered to 125 HIV+ adults, predominantly men. Cronbach's alpha was 0.78, indicating internal consistency reliability. Correlations between the Perceived HIV Self-Management Scale (PHIVSMS) and other validated psychometric instruments measuring generalized self efficacy, dispositional optimism, depressive symptoms, positive and negative affect and HIV quality of life demonstrate the validity of using this scale with an HIV population. The PMCSMS has broad utility as a generic template that can easily be adapted to different medical conditions.
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9 MeSH Terms
Anger management style moderates effects of attention strategy during acute pain induction on physiological responses to subsequent mental stress and recovery: a comparison of chronic pain patients and healthy nonpatients.
Burns JW, Quartana PJ, Bruehl S
(2009) Psychosom Med 71: 454-62
MeSH Terms: Acute Disease, Adaptation, Psychological, Adult, Anger, Attention, Chronic Disease, Cold Temperature, Female, Hemodynamics, Humans, Inhibition, Psychological, Low Back Pain, Male, Mathematics, Middle Aged, Muscle Contraction, Pain, Personality Inventory, Stress, Psychological
Show Abstract · Added March 5, 2014
OBJECTIVES - To examine whether high trait anger-out chronic low back (CLBP) patients would show exceptionally large symptom-specific lower paraspinal (LP) responses, compared with healthy nonpatients, during pain induction, a subsequent mental stressor, and recovery when they were urged to suppress awareness of pain and suffering.
METHODS - CLBP patients (n = 93) and nonpatients (n = 105) were assigned randomly to one of four attention strategy conditions for use during pain induction: sensory-focus, distraction, suppression, or control. All participants underwent a cold pressor, and then performed mental arithmetic. They completed the anger-out (AOS) and anger-in (AIS) subscales of the Anger Expression Inventory.
RESULTS - General Linear Model procedures were used to test Attention Strategy Condition x Patient/Nonpatient Status x AOS (or AIS) x Period interactions for physiological indices. Significant interactions were found such that: a) high trait anger-out patients in the Suppression condition seemed to show the greatest LP reactivity during the mental arithmetic followed by the slowest recovery compared with other conditions; b) high trait anger-out patients and nonpatients in the Suppression condition seemed to show the slowest systolic blood pressure recoveries compared with other conditions.
CONCLUSIONS - Results extend previous work by suggesting that an anger-out style moderates effects of how attention is allocated during pain on responses to and recovery from a subsequent mental stressor. Results provide further evidence that trait anger-out and trait anger-in among CLBP patients are associated with increased LP muscle tension during and after pain and mental stress.
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19 MeSH Terms
Maternal sadness and adolescents' responses to stress in offspring of mothers with and without a history of depression.
Jaser SS, Fear JM, Reeslund KL, Champion JE, Reising MM, Compas BE
(2008) J Clin Child Adolesc Psychol 37: 736-46
MeSH Terms: Adaptation, Psychological, Adolescent, Adult, Attention Deficit and Disruptive Behavior Disorders, Child, Child of Impaired Parents, Depression, Depressive Disorder, Female, Humans, Internal-External Control, Male, Middle Aged, Mother-Child Relations, Mothers, Personality Inventory, Risk Factors, Stress, Psychological
Show Abstract · Added March 11, 2015
This study examined maternal sadness and adolescents' responses to stress in the offspring (n = 72) of mothers with and without a history of depression. Mothers with a history of depression reported higher levels of current depressive symptoms and exhibited greater sadness during interactions with their adolescent children (ages 11-14) than mothers without a history of depression. Similarly, adolescent children of mothers with a history of depression experienced higher rates of internalizing and externalizing symptoms than adolescents of mothers without a history of depression. Regression analyses indicated that adolescents' use of secondary control coping mediated the relationship between observed maternal sadness and adolescents' internalizing and externalizing symptoms, in that higher levels of secondary control coping (e.g., cognitive reframing) were related to fewer symptoms.
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18 MeSH Terms
Psychiatric profile and attention deficits in postural tachycardia syndrome.
Raj V, Haman KL, Raj SR, Byrne D, Blakely RD, Biaggioni I, Robertson D, Shelton RC
(2009) J Neurol Neurosurg Psychiatry 80: 339-44
MeSH Terms: Adolescent, Aged, Anxiety Disorders, Attention Deficit Disorder with Hyperactivity, Comorbidity, Cross-Sectional Studies, Depressive Disorder, Major, Diagnostic and Statistical Manual of Mental Disorders, Female, Humans, Male, Middle Aged, Panic Disorder, Personality Inventory, Postural Orthostatic Tachycardia Syndrome, Young Adult
Show Abstract · Added December 10, 2013
OBJECTIVES - Patients with postural tachycardia syndrome (POTS) often appear anxious and report inattention. Patients with POTS were formally assessed for psychiatric disorders and inattention and compared with patients with attention deficit hyperactivity disorder (ADHD) and control subjects.
METHODS - Patients with POTS (n = 21), ADHD (n = 18) and normal control subjects (n = 20) were assessed for DSM-IV psychiatric disorders and completed a battery of questionnaires that assessed depression, anxiety and ADHD characteristics.
RESULTS - Patients with POTS did not have an increased prevalence of major depression or anxiety disorders, including panic disorder, compared with the general population. Patients with POTS had mild depression. They scored as moderately anxious on the Beck Anxiety Inventory but did not exhibit a high level of anxiety sensitivity. Patients with POTS scored significantly higher on inattention and ADHD subscales than control subjects. These symptoms were not present during childhood.
CONCLUSIONS - Patients with POTS do not have an increased lifetime prevalence of psychiatric disorders. Although they may seem anxious, they do not have excess cognitive anxiety. They do experience significant inattention which may be an important source of disability.
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16 MeSH Terms