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Publication Record


Complications of alloderm and dermamatrix for parotidectomy reconstruction.
Athavale SM, Phillips S, Mangus B, Datta J, Sinard RJ, Netterville JL, Burkey BB, Yarbrough WG
(2012) Head Neck 34: 88-93
MeSH Terms: Collagen, Female, Humans, Male, Parotid Gland, Parotid Neoplasms, Postoperative Complications, Prostheses and Implants, Reconstructive Surgical Procedures, Retrospective Studies, Skin, Artificial
Show Abstract · Added March 7, 2014
BACKGROUND - AlloDerm and DermaMatrix are 2 acellular dermal implants currently used by reconstructive surgeons at our institution for reconstruction of parotidectomy defects. We looked at the postoperative complication rates following subcutaneous implantation of these acellular dermal implants for parotid bed reconstruction.
METHODS - A retrospective analysis was conducted following approval by the Institutional Review Board at Vanderbilt University Medical Center. All parotid and reconstructive operations were performed between 2001 and 2009 by 1 of 4 surgeons in the Department of Otolaryngology-Head and Neck Surgery. Data were collected to determine operative variables and postoperative course. Operative variables assessed were tumor type, type of implant used, type of parotidectomy (total or subtotal), and duration of Jackson Pratt (JP) drain placement.
RESULTS - One hundred patients were analyzed. Sixty-nine AlloDerm implants were associated with 5 complications (7%), whereas 31 DermaMatrix implants were associated with 8 complications (26%) (p = .0107). When comparing total parotidectomies, the complication rate was 1 of 20 for AlloDerm (5%) and 1 of 12 for DermaMatrix (8%) (p = .7061). When looking at subtotal parotidectomies, the incidence of complications was found to be 4 of 49 for AlloDerm (8%) and 7 of 19 for DermaMatrix (37%) (p = .004).
CONCLUSIONS - Our study suggests that DermaMatrix was associated with increased postoperative complications compared to AlloDerm, especially in the subset of patients undergoing subtotal parotidectomy.
Copyright © 2010 Wiley Periodicals, Inc.
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11 MeSH Terms
Systems biology analysis of Sjögren's syndrome and mucosa-associated lymphoid tissue lymphoma in parotid glands.
Hu S, Zhou M, Jiang J, Wang J, Elashoff D, Gorr S, Michie SA, Spijkervet FK, Bootsma H, Kallenberg CG, Vissink A, Horvath S, Wong DT
(2009) Arthritis Rheum 60: 81-92
MeSH Terms: Gene Expression Profiling, Humans, Lymphoid Tissue, Lymphoma, B-Cell, Marginal Zone, Parotid Gland, Parotid Neoplasms, Proteomics, Sjogren's Syndrome, Systems Biology
Show Abstract · Added October 15, 2011
OBJECTIVE - To identify key target genes and activated signaling pathways associated with the pathogenesis of Sjögren's syndrome (SS) by conducting a systems analysis of parotid glands manifesting primary SS or primary SS/mucosa-associated lymphoid tissue (MALT) lymphoma phenotypes.
METHODS - A systems biology approach was used to analyze parotid gland tissue samples obtained from patients with primary SS, patients with primary SS/MALT lymphoma, and subjects without primary SS (non-primary SS controls). The tissue samples were assessed concurrently by gene-expression microarray profiling and proteomics analysis, followed by weighted gene-coexpression network analysis.
RESULTS - Gene-coexpression modules related to primary SS and primary SS/MALT lymphoma were significantly enriched with genes known to be involved in the immune/defense response, apoptosis, cell signaling, gene regulation, and oxidative stress. Detailed functional pathway analyses indicated that primary SS-associated modules were enriched with genes involved in proteasome degradation, apoptosis, signal peptides of the class I major histocompatibility complex (MHC), complement activation, cell growth and death, and integrin-mediated cell adhesion, while primary SS/MALT lymphoma-associated modules were enriched with genes involved in translation, ribosome biogenesis and assembly, proteasome degradation, class I MHC signal peptides, the G13 signaling pathway, complement activation, and integrin-mediated cell adhesion. Combined analyses of gene expression and proteomics data implicated 6 highly connected "hub" genes for distinguishing primary SS from non-primary SS, and 8 hub genes for distinguishing primary SS/MALT lymphoma from primary SS.
CONCLUSION - Systems biology analyses of the parotid glands from patients with primary SS and those with primary SS/MALT lymphoma revealed pathways and molecular targets associated with disease pathogenesis. The identified gene modules/pathways provide further insights into the molecular mechanisms of primary SS and primary SS/MALT lymphoma. The identified disease-hub genes represent promising targets for therapeutic intervention, diagnosis, and prognosis.
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9 MeSH Terms
Age and gender related differences in human parotid gland gene expression.
Srivastava A, Wang J, Zhou H, Melvin JE, Wong DT
(2008) Arch Oral Biol 53: 1058-70
MeSH Terms: Adult, Aged, Aged, 80 and over, Aging, Female, Gene Expression Profiling, Gene Expression Regulation, Humans, Male, Middle Aged, Oligonucleotide Array Sequence Analysis, Parotid Gland, Reverse Transcriptase Polymerase Chain Reaction, Salivary Proteins and Peptides, Sex Characteristics, Young Adult
Show Abstract · Added October 15, 2011
OBJECTIVE - The present study evaluated differences in gene expression associated with age and gender in the human parotid gland.
DESIGN - Parotid gland tissue was analysed using the Affymetrix GeneChip HGU133plus2.0 array.
RESULTS - Differential gene expression, defined as a statistically significant difference with a 1.5-fold or greater change, was detected in 787 gene probe sets; 467 (approximately 59%) showed higher expression in females. Several genes associated with saliva secretion were differentially expressed in male and female parotid glands including vesicle-associated membrane protein 3 VAMP3, synaptosomal-associated protein SNAP23, RAS oncogene family member RAB1A and the syntaxin binding protein STXBP1. Evaluation of gene expression in the youngest and the oldest female subjects revealed that the expression of 228 probe sets were altered during aging; 155 genes were up-regulated in the aged female parotid gland. However, of the genes that were altered during aging, 22 of the 30 probes (73%) classified as being associated with immune responses were down-regulated in the aged parotid gland. A panel of differentially expressed, age- and gender-related genes was selected for validation by quantitative, real-time RT-PCR. Comparable differences in gene expression were detected by both Affymetrix array and quantitative, real-time RT-PCR methods.
CONCLUSIONS - Our data suggest that salivary gland function may be adversely affected in the aged population due, at least in part, to the altered regulation of several categories of genes. Moreover, the gender specific differences in gene expression identified in the present study correlate with the previously observed sexual dimorphism in salivary gland function.
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16 MeSH Terms
Tumors of the accessory lobe of the parotid gland: a 10-year experience.
Lin DT, Coppit GL, Burkey BB, Netterville JL
(2004) Laryngoscope 114: 1652-5
MeSH Terms: Adult, Aged, Biopsy, Needle, Cheek, Diagnosis, Differential, Female, Follow-Up Studies, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Parotid Gland, Parotid Neoplasms, Postoperative Complications, Retrospective Studies, Tomography, X-Ray Computed
Show Abstract · Added March 5, 2014
OBJECTIVES/HYPOTHESIS - The differential diagnosis of midcheek masses include pathology arising from normal anatomic structures or from variations of normal accessory parotid gland tissue. Accessory parotid gland tissue has been described as salivary tissue adjacent to Stenson's duct that is separate from the main body of the parotid gland. We report our 10-year experience with the diagnosis and treatment of eight accessory parotid gland neoplasms that have been followed by the senior authors.
STUDY DESIGN - This is a retrospective review of our experience with eight accessory parotid gland neoplasms.
METHODS - A literature review and retrospective chart review of our experience with accessory parotid gland tumors over the past 10 years. The presentation, evaluation, management, treatment, and outcome were recorded.
RESULTS - Eight cases of accessory lobe parotid tumors were identified, which have been followed since the date of initial treatment. All of the patients presented with a slowly growing cheek mass. There was one case of carcinoma expleomorphic adenoma, one case of undifferentiated carcinoma (small cell carcinoma), one case of basal cell adenocarcinoma, one case of benign salivary cyst, two cases of pleomorphic adenoma, and two cases of monomorphic adenoma. A standard facelift approach or modified Blair incision was used to excise these tumors.
CONCLUSIONS - Neoplasms of the accessory parotid gland are rare. Management of these tumors include a high index of suspicion, good understanding of the anatomy, and meticulous surgical approach.
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16 MeSH Terms