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Development of an eHealth Program for Parents of Adolescents With Type 1 Diabetes.
Whittemore R, Zincavage RM, Jaser SS, Grey M, Coleman JL, Collett D, Delvy R, Basile Ibrahim B, Marceau LD
(2018) Diabetes Educ 44: 72-82
MeSH Terms: Adolescent, Attitude of Health Personnel, Child, Diabetes Mellitus, Type 1, Female, Health Personnel, Humans, Male, Parent-Child Relations, Parents, Program Evaluation, Qualitative Research, Self Care, Surveys and Questionnaires, Telemedicine, Transition to Adult Care
Show Abstract · Added May 18, 2018
Purpose The purpose of this study was to understand the experience of parenting an adolescent with type 1 diabetes (T1DM), to develop a prototype of an eHealth program for parents of adolescents with T1DM, and to evaluate the prototype content and acceptability from the perspective of parents and health care providers. Methods A multiphase method was used generating both qualitative and quantitative data at multiple time points. There were 27 parents of adolescents aged 12 to 18 years with T1DM and 16 health care providers who participated in semistructured interviews to identify parental challenges; 53 parents and 27 providers evaluated the prototype. Thematic content analysis was used to analyze interview transcripts, and descriptive statistics were used to summarize survey data. Results Challenges experienced by parents of adolescents with T1DM included understanding the developmental and hormonal changes of adolescence that affect diabetes care, feeling tension between adolescent independence and parent control, communicating without nagging or conflict, transferring diabetes care responsibility safely, dealing with feelings of stress and distress, and perceiving a lack of resources for T1DM care and insufficient personal time for self-care. In the prototype evaluation, both parents and providers found content to be relevant and provided feedback to guide the development of the full program. Conclusions Parents of adolescents with T1DM and providers expressed a need for parents to have more support in transitioning diabetes care from parent to adolescent. eHealth programs offer an ideal way to address these needs and ultimately can be linked to electronic medical records improving quality and efficiency of health care in this population.
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16 MeSH Terms
Sleep in children with type 1 diabetes and their parents in the T1D Exchange.
Jaser SS, Foster NC, Nelson BA, Kittelsrud JM, DiMeglio LA, Quinn M, Willi SM, Simmons JH, T1D Exchange Clinic Network
(2017) Sleep Med 39: 108-115
MeSH Terms: Blood Glucose, Child, Diabetes Mellitus, Type 1, Female, Glycated Hemoglobin A, Humans, Hypoglycemia, Male, Parents, Registries, Sleep, Sleep Wake Disorders, Surveys and Questionnaires
Show Abstract · Added May 18, 2018
OBJECTIVES - Sleep has physiological and behavioral impacts on diabetes outcomes, yet little is known about the impact of sleep disturbances in children with type 1 diabetes. The current study sought to characterize sleep in children with type 1 diabetes and in their parents and to examine the associations between child sleep, glycemic control and adherence, parent sleep and well-being, parental fear of hypoglycemia, and nocturnal caregiving behavior.
METHODS - Surveys were emailed to parents of 2- to 12-year-old participants in the Type 1 Diabetes (T1D) Exchange clinic registry. Clinical data were obtained from the registry for the 515 respondents.
RESULTS - In our sample, 67% of children met criteria for poor sleep quality. Child sleep quality was related to glycemic control (HbA1c of 7.9% [63 mmol/mol] in children with poor sleep quality vs 7.6% [60 mmol/mol] in children with non-poor sleep quality; P < 0.001) but not mean frequency of blood glucose monitoring (BGM) (7.6 times/day vs 7.4 in poor/non-poor quality; P = 0.56). Associations were similar for sleep duration. Children with poor sleep quality were more likely to experience severe hypoglycemia (4% in children with poor sleep quality vs 1% in children with non-poor sleep quality; P = 0.05) and more likely to experience DKA (7% vs 4%, respectively; P < 0.001). Poorer child sleep quality was associated with poorer parental sleep quality, parental well-being, and fear of hypoglycemia (P < 0.001 for all). Child sleep was not related to the use of diabetes-related technology (CGM, insulin pump).
CONCLUSIONS - Sleep may be a modifiable factor to improve glycemic control and reduce parental distress.
Copyright © 2017 Elsevier B.V. All rights reserved.
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MeSH Terms
Adolescent Participation in HPV Vaccine Clinical Trials: Are Parents Willing?
Erves JC, Mayo-Gamble TL, Hull PC, Duke L, Miller ST
(2017) J Community Health 42: 894-901
MeSH Terms: Adolescent, Clinical Trials as Topic, Health Knowledge, Attitudes, Practice, Humans, Papillomavirus Vaccines, Parents, Patient Acceptance of Health Care, Vaccination
Show Abstract · Added March 27, 2017
Approximately one-quarter of human papillomavirus (HPV) infections are acquired by adolescents, with a higher burden among racial/ethnic minorities. However, racial/ethnic minorities have been underrepresented in previous HPV vaccine trials. Ongoing and future HPV vaccine optimization trials would benefit from racially- and ethnically-diverse sample of adolescent trial participants. This study examined factors influencing parental willingness to consent to their adolescents' participation in HPV vaccine clinical trials and tested for possible racial differences. A convenience sample of parents of adolescents (N = 256) completed a cross-sectional survey. Chi square analyses were used to assess racial differences in parental HPV vaccine awareness and intentions and willingness to consent to their child participating in an HPV vaccine clinical trial. Ordinal logistic regression was used to identify factors associated with willingness. Approximately 47% of parents were willing to allow their adolescent to participate in HPV vaccine clinical trials (30.7% African American and 48.3% Caucasian, p = .081). African Americans had lower HPV vaccine awareness (p = .006) but not lower intentions to vaccinate (p = .086). Parental willingness was positively associated with the following variables: Child's age (p < .039), Perceived Advantages of HPV Vaccination for Adolescents (p = .002), Parental Trust in Medical Researchers (p < .001), and Level of Ease in Understanding Clinical Trial Information (p = .010). Educating parents about the advantages of HPV vaccines for younger adolescents using low-literacy educational materials and building trust between parents and researchers may increase parental willingness to consent to adolescent participation in HPV vaccine clinical trials.
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8 MeSH Terms
Brief report: Sleep disturbances in young children with type 1 diabetes.
Jaser SS, Lord JH, Simmons JH, Malow BA
(2016) Diabetes Res Clin Pract 120: 232-4
MeSH Terms: Child, Preschool, Diabetes Mellitus, Type 1, Female, Humans, Male, Parents, Pilot Projects, Sleep Wake Disorders, Stress, Psychological
Show Abstract · Added June 1, 2017
This multi-method study, including actigraphy, sleep diaries, and questionnaires, indicated significant sleep disturbances in young children with type 1 diabetes (age 3-5) and insufficient sleep duration in children and their parents. Results provide initial support for sleep as a potential target to improve both diabetes outcomes and parental distress.
Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.
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9 MeSH Terms
Fitting meta-analytic structural equation models with complex datasets.
Wilson SJ, Polanin JR, Lipsey MW
(2016) Res Synth Methods 7: 121-39
MeSH Terms: Algorithms, Child, Preschool, Computer Simulation, Cross-Sectional Studies, Databases, Bibliographic, Educational Measurement, Effect Modifier, Epidemiologic, Female, Humans, Infant, Longitudinal Studies, Male, Meta-Analysis as Topic, Models, Statistical, Models, Theoretical, Parent-Child Relations, Parents, Programming Languages, Regression Analysis, Reproducibility of Results, Statistics as Topic
Show Abstract · Added April 6, 2017
A modification of the first stage of the standard procedure for two-stage meta-analytic structural equation modeling for use with large complex datasets is presented. This modification addresses two common problems that arise in such meta-analyses: (a) primary studies that provide multiple measures of the same construct and (b) the correlation coefficients that exhibit substantial heterogeneity, some of which obscures the relationships between the constructs of interest or undermines the comparability of the correlations across the cells. One component of this approach is a three-level random effects model capable of synthesizing a pooled correlation matrix with dependent correlation coefficients. Another component is a meta-regression that can be used to generate covariate-adjusted correlation coefficients that reduce the influence of selected unevenly distributed moderator variables. A non-technical presentation of these techniques is given, along with an illustration of the procedures with a meta-analytic dataset. Copyright © 2016 John Wiley & Sons, Ltd.
Copyright © 2016 John Wiley & Sons, Ltd.
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21 MeSH Terms
Joint detection of copy number variations in parent-offspring trios.
Liu Y, Liu J, Lu J, Peng J, Juan L, Zhu X, Li B, Wang Y
(2016) Bioinformatics 32: 1130-7
MeSH Terms: Algorithms, DNA Copy Number Variations, Genome, Humans, Parents, Software
Show Abstract · Added February 15, 2016
MOTIVATION - Whole genome sequencing (WGS) of parent-offspring trios is a powerful approach for identifying disease-associated genes via detecting copy number variations (CNVs). Existing approaches, which detect CNVs for each individual in a trio independently, usually yield low-detection accuracy. Joint modeling approaches leveraging Mendelian transmission within the parent-offspring trio can be an efficient strategy to improve CNV detection accuracy.
RESULTS - In this study, we developed TrioCNV, a novel approach for jointly detecting CNVs in parent-offspring trios from WGS data. Using negative binomial regression, we modeled the read depth signal while considering both GC content bias and mappability bias. Moreover, we incorporated the family relationship and used a hidden Markov model to jointly infer CNVs for three samples of a parent-offspring trio. Through application to both simulated data and a trio from 1000 Genomes Project, we showed that TrioCNV achieved superior performance than existing approaches.
AVAILABILITY AND IMPLEMENTATION - The software TrioCNV implemented using a combination of Java and R is freely available from the website at https://github.com/yongzhuang/TrioCNV CONTACT: ydwang@hit.edu.cn
SUPPLEMENTARY INFORMATION - Supplementary data are available at Bioinformatics online.
© The Author 2015. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.
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6 MeSH Terms
Development and Psychometric Evaluation of the HPV Clinical Trial Survey for Parents (CTSP-HPV) Using Traditional Survey Development Methods and Community Engagement Principles.
Cunningham J, Wallston KA, Wilkins CH, Hull PC, Miller ST
(2015) Clin Transl Sci 8: 702-9
MeSH Terms: Adolescent, Child, Clinical Trials as Topic, Community-Institutional Relations, Discriminant Analysis, Female, Humans, Linear Models, Male, Papillomavirus Infections, Papillomavirus Vaccines, Parents, Psychometrics, Regression Analysis, Reproducibility of Results, Research Design, Surveys and Questionnaires
Show Abstract · Added July 28, 2016
OBJECTIVE - This study describes the development and psychometric evaluation of HPV Clinical Trial Survey for Parents with Children Aged 9 to 15 (CTSP-HPV) using traditional instrument development methods and community engagement principles.
METHODS - An expert panel and parental input informed survey content and parents recommended study design changes (e.g., flyer wording). A convenience sample of 256 parents completed the final survey measuring parental willingness to consent to HPV clinical trial (CT) participation and other factors hypothesized to influence willingness (e.g., HPV vaccine benefits). Cronbach's a, Spearman correlations, and multiple linear regression were used to estimate internal consistency, convergent and discriminant validity, and predictively validity, respectively.
RESULTS - Internal reliability was confirmed for all scales (a ≥ 0.70.). Parental willingness was positively associated (p < 0.05) with trust in medical researchers, adolescent CT knowledge, HPV vaccine benefits, advantages of adolescent CTs (r range 0.33-0.42), supporting convergent validity. Moderate discriminant construct validity was also demonstrated. Regression results indicate reasonable predictive validity with the six scales accounting for 31% of the variance in parents' willingness.
CONCLUSIONS - This instrument can inform interventions based on factors that influence parental willingness, which may lead to the eventual increase in trial participation. Further psychometric testing is warranted.
© 2015 Wiley Periodicals, Inc.
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17 MeSH Terms
Somatosensory Event-Related Potentials and Association with Tactile Behavioral Responsiveness Patterns in Children with ASD.
Cascio CJ, Gu C, Schauder KB, Key AP, Yoder P
(2015) Brain Topogr 28: 895-903
MeSH Terms: Adolescent, Autism Spectrum Disorder, Brain Mapping, Child, Child, Preschool, Evoked Potentials, Somatosensory, Female, Humans, Male, Parents, Physical Stimulation, Psychophysics, Reaction Time, Somatosensory Cortex, Time Factors, Touch
Show Abstract · Added February 22, 2016
The goal of this study was to explore neural response to touch in children with and without autism spectrum disorder (ASD). Patterns of reduced (hypo-responsiveness) and enhanced (hyper-responsiveness) behavioral reaction to sensory input are prevalent in ASD, but their neural mechanisms are poorly understood. We measured event-related potentials (ERP) to a puff of air on the fingertip and collected parent report of tactile hypo- and hyper-responsiveness in children with ASD (n = 21, mean (SD) age 11.25 (3.09), 2 female), and an age-matched typically developing comparison group (n = 28, mean (SD) age 10.1 (3.08, 2 female). A global measure of ERP response strength approximately 220-270 ms post-stimulus was associated with tactile hypo-responsiveness in ASD, while tactile hyper-responsiveness was associated with earlier neural response (approximately 120-220 ms post-stimulus) in both groups. These neural responses also related to autism severity. These results suggest that, in ASD, tactile hypo- and hyper-responsiveness may reflect different waypoints in the neural processing stream of sensory input. The timing of the relationship for hyper-responsiveness is consistent with somatosensory association cortical response, while that for hypo-responsiveness is more consistent with later processes that may involve allocation of attention or emotional valence to the stimulus.
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16 MeSH Terms
Good cop, bad cop: quality of parental involvement in type 1 diabetes management in youth.
Young MT, Lord JH, Patel NJ, Gruhn MA, Jaser SS
(2014) Curr Diab Rep 14: 546
MeSH Terms: Adaptation, Psychological, Adolescent, Adolescent Behavior, Attitude to Health, Blood Glucose, Blood Glucose Self-Monitoring, Conflict, Psychological, Diabetes Mellitus, Type 1, Diet, Diabetic, Exercise, Glycated Hemoglobin A, Health Knowledge, Attitudes, Practice, Humans, Insulin, Medication Adherence, Monitoring, Physiologic, Parent-Child Relations, Parents, Self Care
Show Abstract · Added March 11, 2015
Sustained parental involvement in diabetes management has been generally advised to counteract the deteriorating adherence and glycemic control often seen during adolescence, yet until recently, little attention has been given to the optimal amount, type, and quality of parental involvement to promote the best health outcomes for adolescents with type 1 diabetes (T1D). This review synthesizes research regarding the involvement of caregivers-primarily mothers and fathers-of youth with T1D, with a focus on biopsychosocial outcomes. The recent literature on parental involvement in diabetes management highlights a shift in focus from not only amount but also the types (e.g., monitoring, problem-solving) and quality (e.g., warm, critical) of involvement in both mothers and fathers. We provide recommendations for ways that both parents can remain involved to facilitate greater collaboration in shared direct and indirect responsibility for diabetes care and improve outcomes in youth with T1D.
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19 MeSH Terms
Check it! A randomized pilot of a positive psychology intervention to improve adherence in adolescents with type 1 diabetes.
Jaser SS, Patel N, Rothman RL, Choi L, Whittemore R
(2014) Diabetes Educ 40: 659-67
MeSH Terms: Adolescent, Adolescent Behavior, Affect, Blood Glucose, Blood Glucose Self-Monitoring, Caregivers, Cognitive Behavioral Therapy, Diabetes Mellitus, Type 1, Directive Counseling, Feasibility Studies, Female, Follow-Up Studies, Humans, Hypoglycemic Agents, Male, Medication Adherence, Parents, Pilot Projects, Quality of Life, Treatment Outcome
Show Abstract · Added March 11, 2015
PURPOSE - The purpose of the current study was to pilot-test a positive psychology intervention to improve adherence to diabetes management in adolescents with type 1 diabetes.
METHODS - A total of 39 adolescents (ages, 13-17 years) with type 1 diabetes and their caregivers were randomized to a positive psychology intervention (n = 20) or an attention control (education) intervention (n = 19). The intervention condition used positive psychology exercises (eg, gratitude, self-affirmation), small gifts, and parent affirmations to boost positive affect. Outcomes included frequency of blood glucose monitoring, quality of life, and glycemic control.
RESULTS - No main effects for treatment were observed at the 6-month follow-up. However, there was a significant association between adolescents' levels of positive affect and measures of adherence, including self-report and meter downloads of glucose monitoring.
CONCLUSIONS - The results from the current study support the assertion that positive affect in the context of diabetes education is an important factor to consider in adolescents with type 1 diabetes.
© 2014 The Author(s).
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20 MeSH Terms