Chronic β-Cell Depolarization Impairs β-Cell Identity by Disrupting a Network of Ca-Regulated Genes.
Stancill JS, Cartailler JP, Clayton HW, O'Connor JT, Dickerson MT, Dadi PK, Osipovich AB, Jacobson DA, Magnuson MA
(2017) Diabetes 66
: 2175-2187MeSH Terms: Animals, Basic Helix-Loop-Helix Transcription Factors, Calcium, Calcium Signaling, Cell Adhesion, Cell Cycle Proteins, Cell Lineage, Cell Polarity, Gene Expression, Gene Expression Regulation, Insulin-Secreting Cells, KATP Channels, Mice, Pancreatic Polypeptide-Secreting Cells, S100 Calcium Binding Protein A6, S100 Calcium-Binding Protein A4, S100 Proteins, Sulfonylurea ReceptorsAdded June 2, 2017
18 MeSH Terms
Metabolic responses to exogenous ghrelin in obesity and early after Roux-en-Y gastric bypass in humans.
Tamboli RA, Antoun J, Sidani RM, Clements A, Harmata EE, Marks-Shulman P, Gaylinn BD, Williams B, Clements RH, Albaugh VL, Abumrad NN
(2017) Diabetes Obes Metab 19
: 1267-1275MeSH Terms: Acylation, Anti-Obesity Agents, Cohort Studies, Combined Modality Therapy, Cross-Over Studies, Energy Metabolism, Gastric Bypass, Ghrelin, Gluconeogenesis, Glucose Clamp Technique, Human Growth Hormone, Humans, Infusions, Intravenous, Insulin Resistance, Liver, Muscle, Skeletal, Obesity, Morbid, Pancreatic Polypeptide, Pancreatic Polypeptide-Secreting Cells, Pituitary Gland, Anterior, Postoperative Care, Preoperative Care, Protein Precursors, Single-Blind MethodAdded April 3, 2017
24 MeSH Terms
Counterregulatory responses to hypoglycemia differ between glimepiride and glyburide in non diabetic individuals.
Joy NG, Tate DB, Davis SN
(2015) Metabolism 64
: 729-37MeSH Terms: Adult, Blood Glucose, C-Peptide, Female, Glucagon, Glucose Clamp Technique, Glyburide, Humans, Hypoglycemia, Hypoglycemic Agents, Insulin, Leptin, Male, Pancreatic Polypeptide, Single-Blind Method, Sulfonylurea CompoundsAdded July 30, 2015
16 MeSH Terms
Position and length of fatty acids strongly affect receptor selectivity pattern of human pancreatic polypeptide analogues.
Mäde V, Bellmann-Sickert K, Kaiser A, Meiler J, Beck-Sickinger AG
(2014) ChemMedChem 9
: 2463-74MeSH Terms: Amino Acid Sequence, Animals, Anti-Obesity Agents, COS Cells, Chlorocebus aethiops, Fatty Acids, Half-Life, Humans, Kinetics, Ligands, Liver, Molecular Sequence Data, Pancreatic Polypeptide, Receptors, Neuropeptide YAdded January 24, 2015
14 MeSH Terms
Pancreatic polypeptide is recognized by two hydrophobic domains of the human Y4 receptor binding pocket.
Pedragosa-Badia X, Sliwoski GR, Dong Nguyen E, Lindner D, Stichel J, Kaufmann KW, Meiler J, Beck-Sickinger AG
(2014) J Biol Chem 289
: 5846-59MeSH Terms: Animals, Binding Sites, COS Cells, Chlorocebus aethiops, Crystallography, X-Ray, HEK293 Cells, Humans, Hydrophobic and Hydrophilic Interactions, Pancreatic Polypeptide, Protein Structure, Quaternary, Protein Structure, Secondary, Protein Structure, Tertiary, Receptors, Neuropeptide YAdded January 24, 2015
13 MeSH Terms
Ptf1a-mediated control of Dll1 reveals an alternative to the lateral inhibition mechanism.
Ahnfelt-Rønne J, Jørgensen MC, Klinck R, Jensen JN, Füchtbauer EM, Deering T, MacDonald RJ, Wright CV, Madsen OD, Serup P
(2012) Development 139
: 33-45MeSH Terms: Animals, Basic Helix-Loop-Helix Transcription Factors, Bromodeoxyuridine, Calcium-Binding Proteins, Chromatin Immunoprecipitation, Galactosides, Gene Expression Regulation, Homeodomain Proteins, Immunohistochemistry, Indoles, Intercellular Signaling Peptides and Proteins, Mice, Mice, Transgenic, Nerve Tissue Proteins, Pancreas, Pancreatic Polypeptide-Secreting Cells, Stem Cells, Transcription Factor HES-1, Transcription FactorsAdded November 6, 2013
19 MeSH Terms
Portal glucose infusion exerts an incretin effect associated with changes in pancreatic neural activity in conscious dogs.
Dunning BE, Moore MC, Ikeda T, Neal DW, Scott MF, Cherrington AD
(2002) Metabolism 51
: 1324-30MeSH Terms: Algorithms, Animals, Dogs, Female, Glucagon, Glucose, Hematocrit, Hormones, Hydrocortisone, Infusions, Intravenous, Insulin, Kinetics, Male, Norepinephrine, Pancreas, Pancreatic Polypeptide, Parasympathetic Nervous System, Portal VeinAdded December 10, 2013
18 MeSH Terms
Pancreatic response to mild non-insulin-induced hypoglycemia does not involve extrinsic neural input.
Sherck SM, Shiota M, Saccomando J, Cardin S, Allen EJ, Hastings JR, Neal DW, Williams PE, Cherrington AD
(2001) Diabetes 50
: 2487-96MeSH Terms: Animals, Blood Glucose, Denervation, Dogs, Female, Glucagon, Hypoglycemia, Insulin, Male, Nervous System, Norepinephrine, Pancreas, Pancreatic PolypeptideAdded December 10, 2013
13 MeSH Terms
Effect of hepatic denervation on the counterregulatory response to insulin-induced hypoglycemia in the dog.
Jackson PA, Cardin S, Coffey CS, Neal DW, Allen EJ, Penaloza AR, Snead WL, Cherrington AD
(2000) Am J Physiol Endocrinol Metab 279
: E1249-57MeSH Terms: 3-Hydroxybutyric Acid, Alanine, Animals, Blood Glucose, Cold Temperature, Consciousness, Dogs, Epinephrine, Fatty Acids, Nonesterified, Female, Glucagon, Glycerol, Heart Rate, Hydrocortisone, Hypoglycemia, Hypoglycemic Agents, Insulin, Lactic Acid, Liver, Male, Norepinephrine, Pancreatic Polypeptide, Parasympathectomy, Vagus NerveAdded December 10, 2013
24 MeSH Terms
Adult insulin- and glucagon-producing cells differentiate from two independent cell lineages.
(2000) Development 127
: 2317-22MeSH Terms: Animals, Cell Differentiation, Cell Lineage, Female, Gene Expression, Glucagon, Homeodomain Proteins, Humans, Insulin, Islets of Langerhans, Male, Mice, Mice, Inbred C57BL, Mice, Inbred CBA, Mice, Transgenic, Pancreatic Polypeptide, Stem Cells, Trans-ActivatorsAdded July 7, 2015
18 MeSH Terms