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Mono(2-ethylhexyl) phthalate (MEHP) and mono(2-ethyl-5-oxohexyl) phthalate (MEOHP) but not di(2-ethylhexyl) phthalate (DEHP) bind productively to the peroxisome proliferator-activated receptor γ.
Kratochvil I, Hofmann T, Rother S, Schlichting R, Moretti R, Scharnweber D, Hintze V, Escher BI, Meiler J, Kalkhof S, von Bergen M
(2019) Rapid Commun Mass Spectrom 33 Suppl 1: 75-85
MeSH Terms: Cell Line, Cell Survival, Humans, Hydrogen Deuterium Exchange-Mass Spectrometry, Molecular Docking Simulation, PPAR gamma, Phthalic Acids, Protein Binding
Added March 21, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
Interrogation of nonconserved human adipose lincRNAs identifies a regulatory role of in adipocyte metabolism.
Zhang X, Xue C, Lin J, Ferguson JF, Weiner A, Liu W, Han Y, Hinkle C, Li W, Jiang H, Gosai S, Hachet M, Garcia BA, Gregory BD, Soccio RE, Hogenesch JB, Seale P, Li M, Reilly MP
(2018) Sci Transl Med 10:
MeSH Terms: Adipocytes, Adipose Tissue, Cell Differentiation, Cell Nucleus, Gene Expression Regulation, Heterogeneous-Nuclear Ribonucleoprotein U, Humans, Lipids, Lipogenesis, PPAR gamma, RNA, Long Noncoding, RNA, Messenger, RNA-Binding Proteins, Transcription, Genetic
Added April 2, 2019
0 Communities
1 Members
0 Resources
14 MeSH Terms
Microbiota-activated PPAR-γ signaling inhibits dysbiotic Enterobacteriaceae expansion.
Byndloss MX, Olsan EE, Rivera-Chávez F, Tiffany CR, Cevallos SA, Lokken KL, Torres TP, Byndloss AJ, Faber F, Gao Y, Litvak Y, Lopez CA, Xu G, Napoli E, Giulivi C, Tsolis RM, Revzin A, Lebrilla CB, Bäumler AJ
(2017) Science 357: 570-575
MeSH Terms: Angiopoietin-Like Protein 4, Anilides, Animals, Anti-Bacterial Agents, Butyrates, Caco-2 Cells, Clostridium, Colitis, Colon, Dysbiosis, Enterobacteriaceae, Epithelial Cells, Female, Gastrointestinal Microbiome, Gene Expression, Homeostasis, Humans, Male, Mice, Mice, Inbred C57BL, Nitrates, Nitric Oxide Synthase Type II, Oxidation-Reduction, PPAR gamma, Signal Transduction, Streptomycin
Added March 30, 2020
0 Communities
1 Members
0 Resources
26 MeSH Terms
p16(Ink4a)-induced senescence of pancreatic beta cells enhances insulin secretion.
Helman A, Klochendler A, Azazmeh N, Gabai Y, Horwitz E, Anzi S, Swisa A, Condiotti R, Granit RZ, Nevo Y, Fixler Y, Shreibman D, Zamir A, Tornovsky-Babeay S, Dai C, Glaser B, Powers AC, Shapiro AM, Magnuson MA, Dor Y, Ben-Porath I
(2016) Nat Med 22: 412-20
MeSH Terms: Aging, Animals, Cell Proliferation, Cellular Senescence, Cyclin-Dependent Kinase Inhibitor p16, Fibroblasts, Gene Expression Regulation, Glucose, Humans, Insulin, Insulin Secretion, Insulin-Secreting Cells, Mice, Mice, Transgenic, PPAR gamma, TOR Serine-Threonine Kinases
Added March 17, 2016
2 Communities
2 Members
0 Resources
16 MeSH Terms
Atherosclerosis following renal injury is ameliorated by pioglitazone and losartan via macrophage phenotype.
Yamamoto S, Zhong J, Yancey PG, Zuo Y, Linton MF, Fazio S, Yang H, Narita I, Kon V
(2015) Atherosclerosis 242: 56-64
MeSH Terms: Angiotensin Receptor Antagonists, Animals, Aortic Diseases, Apolipoproteins E, Apoptosis, Atherosclerosis, Cell Line, Cytokines, Disease Models, Animal, Drug Evaluation, Preclinical, Drug Synergism, Drug Therapy, Combination, Female, Hyperlipidemias, Inflammation, Losartan, Macrophages, Mice, Mice, Inbred C57BL, Mice, Knockout, Nephrectomy, PPAR gamma, Phenotype, Pioglitazone, Renal Insufficiency, Chronic, Renin-Angiotensin System, Thiazolidinediones
Added April 10, 2018
0 Communities
1 Members
0 Resources
27 MeSH Terms
PPARγ activation attenuates opioid consumption and modulates mesolimbic dopamine transmission.
de Guglielmo G, Melis M, De Luca MA, Kallupi M, Li HW, Niswender K, Giordano A, Senzacqua M, Somaini L, Cippitelli A, Gaitanaris G, Demopulos G, Damadzic R, Tapocik J, Heilig M, Ciccocioppo R
(2015) Neuropsychopharmacology 40: 927-37
MeSH Terms: Anilides, Animals, Conditioning, Operant, Dopamine, Dopaminergic Neurons, Heroin, Hypoglycemic Agents, Male, Mice, Transgenic, Morphine, Narcotics, Nucleus Accumbens, PPAR gamma, Pioglitazone, Prefrontal Cortex, Rats, Rats, Wistar, Self Administration, Synaptic Transmission, Thiazolidinediones, Time Factors, Ventral Tegmental Area, gamma-Aminobutyric Acid
Added February 19, 2015
0 Communities
1 Members
0 Resources
23 MeSH Terms
Rare variants in PPARG with decreased activity in adipocyte differentiation are associated with increased risk of type 2 diabetes.
Majithia AR, Flannick J, Shahinian P, Guo M, Bray MA, Fontanillas P, Gabriel SB, GoT2D Consortium, NHGRI JHS/FHS Allelic Spectrum Project, SIGMA T2D Consortium, T2D-GENES Consortium, Rosen ED, Altshuler D
(2014) Proc Natl Acad Sci U S A 111: 13127-32
MeSH Terms: Adipocytes, Adult, Aged, Aged, 80 and over, Case-Control Studies, Cell Differentiation, Diabetes Mellitus, Type 2, Ethnicity, Female, Genetic Predisposition to Disease, Humans, Male, Middle Aged, PPAR gamma, Polymorphism, Single Nucleotide, Risk Factors, Sequence Analysis, DNA
Added April 13, 2017
0 Communities
1 Members
0 Resources
17 MeSH Terms
Retinaldehyde dehydrogenase 1 deficiency inhibits PPARγ-mediated bone loss and marrow adiposity.
Nallamshetty S, Le PT, Wang H, Issacsohn MJ, Reeder DJ, Rhee EJ, Kiefer FW, Brown JD, Rosen CJ, Plutzky J
(2014) Bone 67: 281-91
MeSH Terms: Absorptiometry, Photon, Adiposity, Aldehyde Dehydrogenase, Aldehyde Dehydrogenase 1 Family, Animals, Cells, Cultured, Female, Magnetic Resonance Imaging, Mice, Mice, Knockout, Osteoblasts, Osteogenesis, PPAR gamma, Retinal Dehydrogenase, Reverse Transcriptase Polymerase Chain Reaction, Rosiglitazone, Thiazolidinediones, X-Ray Microtomography
Added September 6, 2016
0 Communities
1 Members
0 Resources
18 MeSH Terms
Reversing vascular dysfunction in rheumatoid arthritis: improved augmentation index but not endothelial function with peroxisome proliferator-activated receptor γ agonist therapy.
Ormseth MJ, Oeser AM, Cunningham A, Bian A, Shintani A, Solus J, Tanner SB, Stein CM
(2014) Arthritis Rheumatol 66: 2331-8
MeSH Terms: Adult, Aged, Antirheumatic Agents, Arthritis, Rheumatoid, Cross-Over Studies, Double-Blind Method, Endothelium, Vascular, Female, Humans, Hypoglycemic Agents, Insulin Resistance, Male, Middle Aged, PPAR gamma, Pioglitazone, Thiazolidinediones, Treatment Outcome
Added January 20, 2015
0 Communities
1 Members
0 Resources
17 MeSH Terms
Do fish oil omega-3 fatty acids enhance antioxidant capacity and mitochondrial fatty acid oxidation in human atrial myocardium via PPARγ activation?
Anderson EJ, Thayne KA, Harris M, Shaikh SR, Darden TM, Lark DS, Williams JM, Chitwood WR, Kypson AP, Rodriguez E
(2014) Antioxid Redox Signal 21: 1156-63
MeSH Terms: Aged, Antioxidants, Fatty Acids, Omega-3, Female, Gene Expression, Heart Atria, Heart Diseases, Humans, Male, Middle Aged, Mitochondria, Heart, Myocardium, Oxidation-Reduction, PPAR gamma, Prospective Studies, Single-Blind Method
Added January 23, 2015
0 Communities
1 Members
0 Resources
16 MeSH Terms