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Clinical and genetic determinants of plasma nevirapine exposure following an intrapartum dose to prevent mother-to-child HIV transmission.
Vardhanabhuti S, Acosta EP, Ribaudo HJ, Severe P, Lalloo U, Kumarasamy N, Taulo F, Kabanda J, Oneko O, Ive P, Sambarey P, Chan ES, Hitti J, Hong F, McMahon D, Haas DW, A5207 ACTG Study Team
(2013) J Infect Dis 208: 662-71
MeSH Terms: Adult, Anti-HIV Agents, Aryl Hydrocarbon Hydroxylases, Chemoprevention, Cytochrome P-450 CYP2B6, Female, HIV Infections, Humans, Infant, Newborn, Infectious Disease Transmission, Vertical, Inhibitory Concentration 50, Male, Metabolic Clearance Rate, Nevirapine, Oxidoreductases, N-Demethylating, Plasma, Polymorphism, Genetic, Pregnancy, Time Factors, Young Adult
Added March 13, 2015
0 Communities
1 Members
0 Resources
20 MeSH Terms
Pharmacokinetics of phase I nevirapine metabolites following a single dose and at steady state.
Fan-Havard P, Liu Z, Chou M, Ling Y, Barrail-Tran A, Haas DW, Taburet AM, ANRS12154 Study Group
(2013) Antimicrob Agents Chemother 57: 2154-60
MeSH Terms: Adult, African Americans, Anti-HIV Agents, Area Under Curve, Aryl Hydrocarbon Hydroxylases, Asians, Biotransformation, Case-Control Studies, Chromatography, Liquid, Cytochrome P-450 CYP2B6, Drug Administration Schedule, Female, HIV Infections, HIV-1, Humans, Male, Nevirapine, Oxidoreductases, N-Demethylating, Polymorphism, Genetic, Tandem Mass Spectrometry
Added March 13, 2015
0 Communities
1 Members
0 Resources
20 MeSH Terms
Associations between HLA-DRB1*0102, HLA-B*5801, and hepatotoxicity during initiation of nevirapine-containing regimens in South Africa.
Phillips E, Bartlett JA, Sanne I, Lederman MM, Hinkle J, Rousseau F, Dunn D, Pavlos R, James I, Mallal SA, Haas DW
(2013) J Acquir Immune Defic Syndr 62: e55-7
MeSH Terms: Adult, Alanine Transaminase, Anti-HIV Agents, Aryl Hydrocarbon Hydroxylases, Aspartate Aminotransferases, Chemical and Drug Induced Liver Injury, Cytochrome P-450 CYP2B6, Double-Blind Method, Female, Genotype, HIV Infections, HLA-B Antigens, HLA-DRB1 Chains, Humans, Male, Multivariate Analysis, Nevirapine, Oxidoreductases, N-Demethylating, Phenotype, Reverse Transcriptase Inhibitors, South Africa
Added March 13, 2015
0 Communities
2 Members
0 Resources
21 MeSH Terms
Genome-wide association study of plasma efavirenz pharmacokinetics in AIDS Clinical Trials Group protocols implicates several CYP2B6 variants.
Holzinger ER, Grady B, Ritchie MD, Ribaudo HJ, Acosta EP, Morse GD, Gulick RM, Robbins GK, Clifford DB, Daar ES, McLaren P, Haas DW
(2012) Pharmacogenet Genomics 22: 858-67
MeSH Terms: Alkynes, Anti-HIV Agents, Aryl Hydrocarbon Hydroxylases, Benzoxazines, Clinical Protocols, Cyclopropanes, Cytochrome P-450 CYP2B6, Genetic Association Studies, Genetic Variation, Genome, Human, Genome-Wide Association Study, HIV Infections, Humans, Oxidoreductases, N-Demethylating, Polymorphism, Genetic
Added March 13, 2015
0 Communities
1 Members
0 Resources
15 MeSH Terms
Neuropsychometric correlates of efavirenz pharmacokinetics and pharmacogenetics following a single oral dose.
Johnson DH, Gebretsadik T, Shintani A, Mayo G, Acosta EP, Stein CM, Haas DW
(2013) Br J Clin Pharmacol 75: 997-1006
MeSH Terms: Administration, Oral, Adult, Alkynes, Anti-HIV Agents, Aryl Hydrocarbon Hydroxylases, Benzoxazines, Cyclopropanes, Cytochrome P-450 CYP2B6, Female, Genotype, Humans, Male, Oxidoreductases, N-Demethylating, Psychomotor Performance
Added March 13, 2015
0 Communities
1 Members
0 Resources
14 MeSH Terms
Genetic determinants of the ankle-brachial index: a meta-analysis of a cardiovascular candidate gene 50K SNP panel in the candidate gene association resource (CARe) consortium.
Wassel CL, Lamina C, Nambi V, Coassin S, Mukamal KJ, Ganesh SK, Jacobs DR, Franceschini N, Papanicolaou GJ, Gibson Q, Yanek LR, van der Harst P, Ferguson JF, Crawford DC, Waite LL, Allison MA, Criqui MH, McDermott MM, Mehra R, Cupples LA, Hwang SJ, Redline S, Kaplan RC, Heiss G, Rotter JI, Boerwinkle E, Taylor HA, Eraso LH, Haun M, Li M, Meisinger C, O'Connell JR, Shuldiner AR, Tybjærg-Hansen A, Frikke-Schmidt R, Kollerits B, Rantner B, Dieplinger B, Stadler M, Mueller T, Haltmayer M, Klein-Weigel P, Summerer M, Wichmann HE, Asselbergs FW, Navis G, Mateo Leach I, Brown-Gentry K, Goodloe R, Assimes TL, Becker DM, Cooke JP, Absher DM, Olin JW, Mitchell BD, Reilly MP, Mohler ER, North KE, Reiner AP, Kronenberg F, Murabito JM
(2012) Atherosclerosis 222: 138-47
MeSH Terms: Adult, African Americans, Aged, Ankle Brachial Index, Aryl Hydrocarbon Hydroxylases, Cytochrome P-450 CYP2B6, Female, Humans, Male, Middle Aged, Oxidoreductases, N-Demethylating, Peripheral Arterial Disease, Polymorphism, Single Nucleotide, Risk Factors, Transcription Factor 7-Like 2 Protein, Whites
Added December 10, 2013
0 Communities
2 Members
0 Resources
16 MeSH Terms
Genome-scale epigenetic reprogramming during epithelial-to-mesenchymal transition.
McDonald OG, Wu H, Timp W, Doi A, Feinberg AP
(2011) Nat Struct Mol Biol 18: 867-74
MeSH Terms: Animals, Cell Line, Cell Movement, Chromatin Assembly and Disassembly, Chromatin Immunoprecipitation, DNA Methylation, Epigenesis, Genetic, Epithelial Cells, Epithelial-Mesenchymal Transition, Histone Demethylases, Histones, Mesenchymal Stem Cells, Mice, Neoplastic Stem Cells, Oxidoreductases, N-Demethylating, Transforming Growth Factor beta
Added May 5, 2016
0 Communities
1 Members
0 Resources
16 MeSH Terms
Effect of CYP2B6, ABCB1, and CYP3A5 polymorphisms on efavirenz pharmacokinetics and treatment response: an AIDS Clinical Trials Group study.
Ribaudo HJ, Liu H, Schwab M, Schaeffeler E, Eichelbaum M, Motsinger-Reif AA, Ritchie MD, Zanger UM, Acosta EP, Morse GD, Gulick RM, Robbins GK, Clifford D, Haas DW
(2010) J Infect Dis 202: 717-22
MeSH Terms: ATP Binding Cassette Transporter, Subfamily B, ATP Binding Cassette Transporter, Subfamily B, Member 1, Alkynes, Anti-HIV Agents, Aryl Hydrocarbon Hydroxylases, Benzoxazines, Blacks, Cyclopropanes, Cytochrome P-450 CYP2B6, Cytochrome P-450 CYP3A, Female, HIV Infections, Hispanic or Latino, Humans, Male, Oxidoreductases, N-Demethylating, Pharmacogenetics, Polymorphism, Single Nucleotide, Reverse Transcriptase Inhibitors, Treatment Outcome, Whites
Added March 13, 2015
0 Communities
1 Members
0 Resources
21 MeSH Terms
CYP2B6 variants and plasma efavirenz concentrations during antiretroviral therapy in Port-au-Prince, Haiti.
Leger P, Dillingham R, Beauharnais CA, Kashuba AD, Rezk NL, Fitzgerald DW, Pape JW, Haas DW
(2009) J Infect Dis 200: 955-64
MeSH Terms: Adult, Alkynes, Anti-HIV Agents, Aryl Hydrocarbon Hydroxylases, Base Sequence, Benzoxazines, Cyclopropanes, Cytochrome P-450 CYP2B6, Female, HIV Infections, Haiti, Haplotypes, Humans, Linkage Disequilibrium, Male, Oxidoreductases, N-Demethylating, Polymorphism, Genetic
Added March 13, 2015
0 Communities
1 Members
0 Resources
17 MeSH Terms
Associations between CYP2B6 polymorphisms and pharmacokinetics after a single dose of nevirapine or efavirenz in African americans.
Haas DW, Gebretsadik T, Mayo G, Menon UN, Acosta EP, Shintani A, Floyd M, Stein CM, Wilkinson GR
(2009) J Infect Dis 199: 872-80
MeSH Terms: Alkynes, Anti-HIV Agents, Area Under Curve, Aryl Hydrocarbon Hydroxylases, Benzoxazines, Blacks, Cyclopropanes, Cytochrome P-450 CYP2B6, Genotype, HIV Seronegativity, Humans, Linkage Disequilibrium, Metabolic Clearance Rate, Nevirapine, Oxidoreductases, N-Demethylating, Polymorphism, Genetic, Safety
Added March 13, 2015
0 Communities
1 Members
0 Resources
17 MeSH Terms