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Results: 1 to 10 of 54

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In Vitro Activation of Cytochrome P450 46A1 (CYP46A1) by Efavirenz-Related Compounds.
Mast N, Verwilst P, Wilkey CJ, Guengerich FP, Pikuleva IA
(2020) J Med Chem 63: 6477-6488
MeSH Terms: Alkynes, Allosteric Site, Benzoxazines, Catalytic Domain, Cholesterol, Cholesterol 24-Hydroxylase, Cyclopropanes, Cytochrome P-450 CYP3A Inducers, Humans, Hydroxylation, In Vitro Techniques, Pharmaceutical Preparations, Protein Conformation
Added March 3, 2020
0 Communities
1 Members
0 Resources
13 MeSH Terms
Greater Weight Gain in Treatment-naive Persons Starting Dolutegravir-based Antiretroviral Therapy.
Bourgi K, Rebeiro PF, Turner M, Castilho JL, Hulgan T, Raffanti SP, Koethe JR, Sterling TR
(2020) Clin Infect Dis 70: 1267-1274
MeSH Terms: Adult, Female, HIV Infections, HIV Integrase Inhibitors, Heterocyclic Compounds, 3-Ring, Humans, Male, Oxazines, Piperazines, Pyridones, Reverse Transcriptase Inhibitors, Weight Gain
Added December 11, 2019
0 Communities
1 Members
0 Resources
12 MeSH Terms
Race/Ethnicity and the Pharmacogenetics of Reported Suicidality With Efavirenz Among Clinical Trials Participants.
Mollan KR, Tierney C, Hellwege JN, Eron JJ, Hudgens MG, Gulick RM, Haubrich R, Sax PE, Campbell TB, Daar ES, Robertson KR, Ventura D, Ma Q, Edwards DRV, Haas DW, AIDS Clinical Trials Group
(2017) J Infect Dis 216: 554-564
MeSH Terms: Adult, Alkynes, Anti-HIV Agents, Benzoxazines, Continental Population Groups, Cyclopropanes, Cytochrome P-450 CYP2A6, Cytochrome P-450 CYP2B6, Ethnic Groups, Female, Gene Frequency, Genotype, HIV Infections, Humans, Male, Pharmacogenetics, Polymorphism, Single Nucleotide, Proportional Hazards Models, Risk Factors, Suicidal Ideation, Suicide, Treatment Outcome
Added March 3, 2020
0 Communities
1 Members
0 Resources
22 MeSH Terms
Brief Report: Weight Gain in Persons With HIV Switched From Efavirenz-Based to Integrase Strand Transfer Inhibitor-Based Regimens.
Norwood J, Turner M, Bofill C, Rebeiro P, Shepherd B, Bebawy S, Hulgan T, Raffanti S, Haas DW, Sterling TR, Koethe JR
(2017) J Acquir Immune Defic Syndr 76: 527-531
MeSH Terms: Adult, Alkynes, Benzoxazines, Cohort Studies, Cyclopropanes, Female, HIV Infections, HIV Integrase Inhibitors, Humans, Male, Middle Aged, Retrospective Studies, Reverse Transcriptase Inhibitors, Weight Gain
Added March 14, 2018
0 Communities
2 Members
0 Resources
14 MeSH Terms
cytochrome P450 46A1 (CYP46A1) activation by neuroactive compounds.
Mast N, Anderson KW, Johnson KM, Phan TTN, Guengerich FP, Pikuleva IA
(2017) J Biol Chem 292: 12934-12946
MeSH Terms: Acetylcholine, Alkynes, Allosteric Regulation, Amino Acid Substitution, Anti-HIV Agents, Aspartic Acid, Benzoxazines, Binding Sites, Biocatalysis, Cholesterol 24-Hydroxylase, Cyclopropanes, Deuterium Exchange Measurement, Enzyme Activation, Glutamic Acid, Ligands, Models, Molecular, Molecular Docking Simulation, Mutagenesis, Site-Directed, Mutation, Nerve Tissue Proteins, Peptide Fragments, Protein Conformation, Recombinant Fusion Proteins, gamma-Aminobutyric Acid
Added March 14, 2018
0 Communities
1 Members
0 Resources
24 MeSH Terms
Novel Small Molecule JP-153 Targets the Src-FAK-Paxillin Signaling Complex to Inhibit VEGF-Induced Retinal Angiogenesis.
Toutounchian JJ, Pagadala J, Miller DD, Baudry J, Park F, Chaum E, Morales-Tirado , Yates CR
(2017) Mol Pharmacol 91: 1-13
MeSH Terms: Animals, Benzoxazines, Cell Movement, Cell Proliferation, Disease Models, Animal, Endothelial Cells, Focal Adhesion Protein-Tyrosine Kinases, Humans, Mice, Inbred C57BL, Models, Biological, Oxygen, Paxillin, Retinal Neovascularization, Signal Transduction, Small Molecule Libraries, Vascular Endothelial Growth Factor A, src-Family Kinases
Added June 11, 2018
0 Communities
1 Members
0 Resources
MeSH Terms
The metabolic and cardiovascular consequences of obesity in persons with HIV on long-term antiretroviral therapy.
Koethe JR, Grome H, Jenkins CA, Kalams SA, Sterling TR
(2016) AIDS 30: 83-91
MeSH Terms: Adult, Alkynes, Anti-Retroviral Agents, Benzoxazines, Cardiovascular Diseases, Cohort Studies, Cyclopropanes, Emtricitabine, Female, HIV Infections, Humans, Male, Metabolic Diseases, Middle Aged, Obesity, Risk Assessment, Tenofovir
Added February 17, 2016
0 Communities
1 Members
0 Resources
17 MeSH Terms
Combined effect of CYP2B6 and NAT2 genotype on plasma efavirenz exposure during rifampin-based antituberculosis therapy in the STRIDE study.
Luetkemeyer AF, Rosenkranz SL, Lu D, Grinsztejn B, Sanchez J, Ssemmanda M, Sanne I, McIlleron H, Havlir DV, Haas DW, Adult AIDS Clinical Trials Group A5221 and A5243 Study Teams
(2015) Clin Infect Dis 60: 1860-3
MeSH Terms: Alkynes, Antitubercular Agents, Arylamine N-Acetyltransferase, Benzoxazines, Cyclopropanes, Cytochrome P-450 CYP2B6, Female, Genotype, HIV Infections, Humans, Male, Peru, Pharmacogenetics, Rifampin, South Africa, Tuberculosis, Uganda
Added March 13, 2015
0 Communities
1 Members
0 Resources
17 MeSH Terms
Pharmacogenetics of plasma efavirenz exposure in HIV-infected adults and children in South Africa.
Sinxadi PZ, Leger PD, McIlleron HM, Smith PJ, Dave JA, Levitt NS, Maartens G, Haas DW
(2015) Br J Clin Pharmacol 80: 146-56
MeSH Terms: Adolescent, Adult, African Continental Ancestry Group, Alkynes, Anti-HIV Agents, Benzoxazines, Child, Child, Preschool, Cyclopropanes, Cytochrome P-450 CYP2B6, Female, Genotype, HIV Infections, Humans, Male, Middle Aged, Polymorphism, Single Nucleotide, South Africa, Young Adult
Added March 13, 2015
0 Communities
1 Members
0 Resources
19 MeSH Terms
Genome-wide association study of virologic response with efavirenz-containing or abacavir-containing regimens in AIDS clinical trials group protocols.
Lehmann DS, Ribaudo HJ, Daar ES, Gulick RM, Haubrich RH, Robbins GK, de Bakker PI, Haas DW, McLaren PJ
(2015) Pharmacogenet Genomics 25: 51-9
MeSH Terms: Acquired Immunodeficiency Syndrome, Alkynes, Anti-HIV Agents, Benzoxazines, Cyclopropanes, Dideoxynucleosides, Drug Therapy, Combination, Genome-Wide Association Study, HIV Infections, HIV-1, Humans, Polymorphism, Single Nucleotide, Randomized Controlled Trials as Topic, Treatment Outcome
Added March 13, 2015
0 Communities
1 Members
0 Resources
14 MeSH Terms