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Results: 1 to 10 of 14

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The primary function of gp130 signaling in osteoblasts is to maintain bone formation and strength, rather than promote osteoclast formation.
Johnson RW, Brennan HJ, Vrahnas C, Poulton IJ, McGregor NE, Standal T, Walker EC, Koh TT, Nguyen H, Walsh NC, Forwood MR, Martin TJ, Sims NA
(2014) J Bone Miner Res 29: 1492-505
MeSH Terms: Adaptor Proteins, Signal Transducing, Animals, Bone and Bones, Cell Count, Cell Lineage, Collagen Type I, Collagen Type I, alpha 1 Chain, Cytokine Receptor gp130, Female, Gene Deletion, Gene Knockdown Techniques, Glycoproteins, Integrases, Intercellular Signaling Peptides and Proteins, Male, Mice, Inbred C57BL, Mice, Knockout, Models, Biological, Organ Size, Osteoblasts, Osteocalcin, Osteoclasts, Osteocytes, Osteogenesis, Reproducibility of Results, Signal Transduction, Sp7 Transcription Factor, Transcription Factors
Added March 26, 2019
0 Communities
1 Members
0 Resources
28 MeSH Terms
Transforming growth factor β suppresses osteoblast differentiation via the vimentin activating transcription factor 4 (ATF4) axis.
Lian N, Lin T, Liu W, Wang W, Li L, Sun S, Nyman JS, Yang X
(2012) J Biol Chem 287: 35975-84
MeSH Terms: Activating Transcription Factor 4, Animals, COS Cells, Cell Differentiation, Cell Line, Tumor, Chlorocebus aethiops, Mice, Mice, Knockout, Osteoblasts, Osteocalcin, Phosphatidylinositol 3-Kinases, Proto-Oncogene Proteins c-akt, Rats, Signal Transduction, Smad Proteins, TOR Serine-Threonine Kinases, Transcription, Genetic, Transforming Growth Factor beta, Up-Regulation, Vimentin
Added October 31, 2013
1 Communities
1 Members
0 Resources
20 MeSH Terms
Degradable segmented polyurethane elastomers for bone tissue engineering: effect of polycaprolactone content.
Kavlock KD, Whang K, Guelcher SA, Goldstein AS
(2013) J Biomater Sci Polym Ed 24: 77-93
MeSH Terms: Animals, Bone Morphogenetic Protein 2, Cell Differentiation, Cells, Cultured, Elastomers, Male, Mesenchymal Stem Cells, Osteoblasts, Osteocalcin, Polyesters, Polyurethanes, Porosity, RNA, Messenger, Rats, Rats, Sprague-Dawley, Tissue Engineering, Tissue Scaffolds
Added February 23, 2016
1 Communities
1 Members
0 Resources
17 MeSH Terms
Chondrocytic Atf4 regulates osteoblast differentiation and function via Ihh.
Wang W, Lian N, Ma Y, Li L, Gallant RC, Elefteriou F, Yang X
(2012) Development 139: 601-11
MeSH Terms: Activating Transcription Factor 4, Animals, Bone Development, Cell Differentiation, Cells, Cultured, Chondrocytes, Collagen Type II, Female, Growth Plate, Hedgehog Proteins, Integrin-Binding Sialoprotein, Male, Mice, Mice, Transgenic, Osteoblasts, Osteocalcin, Osteogenesis
Added November 14, 2013
0 Communities
2 Members
0 Resources
17 MeSH Terms
Osteoblasts derived from induced pluripotent stem cells form calcified structures in scaffolds both in vitro and in vivo.
Bilousova G, Jun du H, King KB, De Langhe S, Chick WS, Torchia EC, Chow KS, Klemm DJ, Roop DR, Majka SM
(2011) Stem Cells 29: 206-16
MeSH Terms: Animals, Calcification, Physiologic, Cell Differentiation, Cells, Cultured, Gene Expression Regulation, Developmental, Induced Pluripotent Stem Cells, Integrin-Binding Sialoprotein, Mice, Mice, Inbred ICR, Mice, Nude, Osteoblasts, Osteocalcin, Osteogenesis, Phenotype, Tissue Scaffolds
Added August 4, 2015
1 Communities
1 Members
0 Resources
15 MeSH Terms
Vimentin inhibits ATF4-mediated osteocalcin transcription and osteoblast differentiation.
Lian N, Wang W, Li L, Elefteriou F, Yang X
(2009) J Biol Chem 284: 30518-25
MeSH Terms: Activating Transcription Factor 4, Animals, Biomarkers, Cell Differentiation, Cells, Cultured, Chromatography, Affinity, Osteoblasts, Osteocalcin, Osteogenesis, Protein Binding, Rats, Transcription, Genetic, Vimentin
Added November 14, 2013
0 Communities
2 Members
0 Resources
13 MeSH Terms
Progressive recruitment of Runx2 to genomic targets despite decreasing expression during osteoblast differentiation.
Pregizer S, Baniwal SK, Yan X, Borok Z, Frenkel B
(2008) J Cell Biochem 105: 965-70
MeSH Terms: Animals, Cell Differentiation, Cell Line, Core Binding Factor Alpha 1 Subunit, Gene Expression Regulation, Developmental, Mice, Osteoblasts, Osteocalcin, Promoter Regions, Genetic, Protein Transport, RNA, Messenger, Time Factors, Transcription Factors
Added September 23, 2013
0 Communities
1 Members
0 Resources
13 MeSH Terms
Supraphysiological testosterone enanthate administration prevents bone loss and augments bone strength in gonadectomized male and female rats.
Yarrow JF, Conover CF, Purandare AV, Bhakta AM, Zheng N, Conrad B, Altman MK, Franz SE, Wronski TJ, Borst SE
(2008) Am J Physiol Endocrinol Metab 295: E1213-22
MeSH Terms: Amino Acids, Androgens, Animals, Body Weight, Bone and Bones, Creatinine, Dihydrotestosterone, Estradiol, Female, Femur, Kidney, Male, Muscle, Skeletal, Orchiectomy, Organ Size, Osteocalcin, Osteoporosis, Ovariectomy, Rats, Rats, Inbred F344, Tensile Strength, Testosterone, Tibia
Added September 20, 2016
0 Communities
1 Members
0 Resources
23 MeSH Terms
Synthesis and characterization of segmented poly(esterurethane urea) elastomers for bone tissue engineering.
Kavlock KD, Pechar TW, Hollinger JO, Guelcher SA, Goldstein AS
(2007) Acta Biomater 3: 475-84
MeSH Terms: Alkaline Phosphatase, Animals, Biocompatible Materials, Bone and Bones, Cell Count, Cell Culture Techniques, Cells, Cultured, Elastomers, Male, Molecular Structure, Osteocalcin, Osteopontin, Polyurethanes, RNA, Messenger, Rats, Rats, Sprague-Dawley, Stromal Cells, Temperature, Tissue Engineering, Urea
Added February 23, 2016
1 Communities
1 Members
0 Resources
20 MeSH Terms
Potential effect of inter-genic action on peak bone mass (PBM) in Chinese females.
Deng FY, Long JR, Lei SF, Li MX, Deng HW
(2005) Yi Chuan Xue Bao 32: 1003-10
MeSH Terms: Absorptiometry, Photon, Adult, Alleles, Asians, Blood Proteins, Bone Density, China, Collagen, Collagen Type I, Estrogen Receptor alpha, Female, Femur, Gene Frequency, Genotype, Humans, Interleukin-6, Lumbar Vertebrae, Osteocalcin, Parathyroid Hormone, Polymerase Chain Reaction, Polymorphism, Genetic, Polymorphism, Restriction Fragment Length, Receptors, Calcitriol, Young Adult, alpha-2-HS-Glycoprotein
Added December 10, 2013
0 Communities
1 Members
0 Resources
25 MeSH Terms