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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 6 of 6

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Large-scale whole-exome sequencing association studies identify rare functional variants influencing serum urate levels.
Tin A, Li Y, Brody JA, Nutile T, Chu AY, Huffman JE, Yang Q, Chen MH, Robinson-Cohen C, Macé A, Liu J, Demirkan A, Sorice R, Sedaghat S, Swen M, Yu B, Ghasemi S, Teumer A, Vollenweider P, Ciullo M, Li M, Uitterlinden AG, Kraaij R, Amin N, van Rooij J, Kutalik Z, Dehghan A, McKnight B, van Duijn CM, Morrison A, Psaty BM, Boerwinkle E, Fox CS, Woodward OM, Köttgen A
(2018) Nat Commun 9: 4228
MeSH Terms: Exome, Genetic Predisposition to Disease, Glucose Transport Proteins, Facilitative, Humans, Kidney Function Tests, Meta-Analysis as Topic, Organic Anion Transporters, Organic Cation Transport Proteins, Protein Structure, Secondary, Uric Acid
Added January 3, 2019
0 Communities
1 Members
0 Resources
MeSH Terms
Contribution of Organic Anion-Transporting Polypeptides 1A/1B to Doxorubicin Uptake and Clearance.
Lee HH, Leake BF, Kim RB, Ho RH
(2017) Mol Pharmacol 91: 14-24
MeSH Terms: ATP Binding Cassette Transporter, Subfamily B, Member 1, Animals, Biological Transport, Cell Membrane, Dogs, Doxorubicin, HeLa Cells, Humans, Kinetics, Liver, Liver-Specific Organic Anion Transporter 1, Madin Darby Canine Kidney Cells, Male, Mice, Models, Biological, Mutant Proteins, Organic Anion Transporters, Organic Anion Transporters, Sodium-Independent, Organic Cation Transport Proteins, Rats, Transfection
Added November 10, 2016
0 Communities
1 Members
0 Resources
21 MeSH Terms
A Longitudinal HbA1c Model Elucidates Genes Linked to Disease Progression on Metformin.
Goswami S, Yee SW, Xu F, Sridhar SB, Mosley JD, Takahashi A, Kubo M, Maeda S, Davis RL, Roden DM, Hedderson MM, Giacomini KM, Savic RM
(2016) Clin Pharmacol Ther 100: 537-547
MeSH Terms: Adult, Aged, Aged, 80 and over, Diabetes Mellitus, Type 2, Disease Progression, Female, Glycated Hemoglobin A, Humans, Hypoglycemic Agents, Longitudinal Studies, Male, Membrane Proteins, Metformin, Middle Aged, Nonlinear Dynamics, Organic Cation Transport Proteins, Organic Cation Transporter 2, Pharmacogenomic Variants, Polymorphism, Single Nucleotide, Tumor Suppressor Proteins, Young Adult
Added March 24, 2020
0 Communities
1 Members
0 Resources
21 MeSH Terms
A common 5'-UTR variant in MATE2-K is associated with poor response to metformin.
Choi JH, Yee SW, Ramirez AH, Morrissey KM, Jang GH, Joski PJ, Mefford JA, Hesselson SE, Schlessinger A, Jenkins G, Castro RA, Johns SJ, Stryke D, Sali A, Ferrin TE, Witte JS, Kwok PY, Roden DM, Wilke RA, McCarty CA, Davis RL, Giacomini KM
(2011) Clin Pharmacol Ther 90: 674-84
MeSH Terms: Adult, Aged, Alleles, Animals, Diabetes Mellitus, Type 2, Female, Genetic Variation, Glycated Hemoglobin A, HCT116 Cells, HEK293 Cells, Haplotypes, Humans, Hypoglycemic Agents, LLC-PK1 Cells, Luciferases, Male, Metformin, Middle Aged, Organic Cation Transport Proteins, Polymorphism, Genetic, Promoter Regions, Genetic, Racial Groups, Retrospective Studies, Swine, Treatment Outcome
Added June 26, 2014
0 Communities
1 Members
0 Resources
25 MeSH Terms
Modulation of drug block of the cardiac potassium channel KCNA5 by the drug transporters OCTN1 and MDR1.
Yang T, McBride BF, Leake BF, Kim RB, Roden DM
(2010) Br J Pharmacol 161: 1023-33
MeSH Terms: ATP Binding Cassette Transporter, Subfamily B, ATP Binding Cassette Transporter, Subfamily B, Member 1, Animals, Anti-Arrhythmia Agents, Binding Sites, Biological Transport, CHO Cells, Cell Line, Cricetinae, Cricetulus, Gene Expression Regulation, Humans, Kv1.5 Potassium Channel, Organic Cation Transport Proteins, Protein Binding, Swine, Symporters
Added March 7, 2014
1 Communities
2 Members
2 Resources
17 MeSH Terms
The organic cation transporter, OCTN1, expressed in the human heart, potentiates antagonism of the HERG potassium channel.
McBride BF, Yang T, Liu K, Urban TJ, Giacomini KM, Kim RB, Roden DM
(2009) J Cardiovasc Pharmacol 54: 63-71
MeSH Terms: Anti-Arrhythmia Agents, Arrhythmias, Cardiac, Cation Transport Proteins, Electrophysiology, Ether-A-Go-Go Potassium Channels, Flecainide, Gene Expression, Heart, Humans, Immunohistochemistry, In Situ Hybridization, Inhibitory Concentration 50, Myocytes, Cardiac, Organic Cation Transport Proteins, Patch-Clamp Techniques, Potassium Channels, Quinidine, Sulfonamides, Symporters
Added June 26, 2014
0 Communities
1 Members
0 Resources
19 MeSH Terms