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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 16

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Human DNA polymerase η accommodates RNA for strand extension.
Su Y, Egli M, Guengerich FP
(2017) J Biol Chem 292: 18044-18051
MeSH Terms: 8-Hydroxy-2'-Deoxyguanosine, Base Pair Mismatch, DNA Primers, DNA Replication, DNA-Directed DNA Polymerase, Deoxyguanosine, Electrophoretic Mobility Shift Assay, Humans, Kinetics, Nucleic Acid Heteroduplexes, Nucleic Acid Hybridization, Oligodeoxyribonucleotides, Oligoribonucleotides, Pyrimidine Dimers, RNA, Recombinant Proteins, Reverse Transcription, Substrate Specificity, Transcription Elongation, Genetic
Added March 14, 2018
0 Communities
1 Members
0 Resources
19 MeSH Terms
Structural basis for 2'-5'-oligoadenylate binding and enzyme activity of a viral RNase L antagonist.
Ogden KM, Hu L, Jha BK, Sankaran B, Weiss SR, Silverman RH, Patton JT, Prasad BV
(2015) J Virol 89: 6633-45
MeSH Terms: Adenine Nucleotides, Capsid Proteins, Catalytic Domain, Crystallography, X-Ray, Exoribonucleases, Oligoribonucleotides, Protein Binding, Protein Conformation, Rotavirus
Added April 26, 2017
0 Communities
1 Members
0 Resources
9 MeSH Terms
Anti-microRNA-21 oligonucleotides prevent Alport nephropathy progression by stimulating metabolic pathways.
Gomez IG, MacKenna DA, Johnson BG, Kaimal V, Roach AM, Ren S, Nakagawa N, Xin C, Newitt R, Pandya S, Xia TH, Liu X, Borza DB, Grafals M, Shankland SJ, Himmelfarb J, Portilla D, Liu S, Chau BN, Duffield JS
(2015) J Clin Invest 125: 141-56
MeSH Terms: Animals, Autoantigens, Collagen Type IV, Disease Progression, Fibrosis, Kidney, Metabolic Networks and Pathways, Mice, 129 Strain, MicroRNAs, Nephritis, Hereditary, Oligoribonucleotides, Antisense, Reactive Oxygen Species, Transcriptome, Up-Regulation
Added December 2, 2016
1 Communities
1 Members
0 Resources
14 MeSH Terms
Homologous 2',5'-phosphodiesterases from disparate RNA viruses antagonize antiviral innate immunity.
Zhang R, Jha BK, Ogden KM, Dong B, Zhao L, Elliott R, Patton JT, Silverman RH, Weiss SR
(2013) Proc Natl Acad Sci U S A 110: 13114-9
MeSH Terms: 2',5'-Oligoadenylate Synthetase, Adenine Nucleotides, Amino Acid Sequence, Animals, Binding Sites, Capsid Proteins, Cell Line, Cells, Cultured, Endoribonucleases, Host-Pathogen Interactions, Humans, Immunity, Innate, Immunoblotting, Macrophages, Mice, Mice, Knockout, Molecular Sequence Data, Murine hepatitis virus, Mutation, Oligoribonucleotides, Phosphoric Diester Hydrolases, RNA Virus Infections, RNA Viruses, Rotavirus, Sequence Homology, Amino Acid, Viral Nonstructural Proteins
Added April 3, 2019
0 Communities
1 Members
0 Resources
MeSH Terms
Structure and nuclease resistance of 2',4'-constrained 2'-O-methoxyethyl (cMOE) and 2'-O-ethyl (cEt) modified DNAs.
Pallan PS, Allerson CR, Berdeja A, Seth PP, Swayze EE, Prakash TP, Egli M
(2012) Chem Commun (Camb) 48: 8195-7
MeSH Terms: DNA, Deoxyribonucleases, Models, Molecular, Nucleosides, Oligoribonucleotides
Added May 27, 2014
0 Communities
1 Members
0 Resources
5 MeSH Terms
Crystal structure, stability and in vitro RNAi activity of oligoribonucleotides containing the ribo-difluorotoluyl nucleotide: insights into substrate requirements by the human RISC Ago2 enzyme.
Li F, Pallan PS, Maier MA, Rajeev KG, Mathieu SL, Kreutz C, Fan Y, Sanghvi J, Micura R, Rozners E, Manoharan M, Egli M
(2007) Nucleic Acids Res 35: 6424-38
MeSH Terms: Argonaute Proteins, Base Pair Mismatch, Base Pairing, Crystallography, X-Ray, Eukaryotic Initiation Factor-2, Fluorobenzenes, HeLa Cells, Humans, Hydrogen Bonding, Models, Molecular, Nucleotides, Oligoribonucleotides, Osmotic Pressure, RNA Interference, RNA, Small Interfering, RNA-Induced Silencing Complex, Substrate Specificity, Thermodynamics
Added March 5, 2014
0 Communities
1 Members
0 Resources
18 MeSH Terms
Stabilizing contributions of sulfur-modified nucleotides: crystal structure of a DNA duplex with 2'-O-[2-(methoxy)ethyl]-2-thiothymidines.
Diop-Frimpong B, Prakash TP, Rajeev KG, Manoharan M, Egli M
(2005) Nucleic Acids Res 33: 5297-307
MeSH Terms: Base Pairing, Crystallography, X-Ray, DNA, Models, Molecular, Nucleic Acid Conformation, Oligoribonucleotides, Antisense, Sulfur, Thionucleotides, Thymidine
Added March 5, 2014
0 Communities
1 Members
0 Resources
9 MeSH Terms
Syntheses of 4'-thioribonucleosides and thermodynamic stability and crystal structure of RNA oligomers with incorporated 4'-thiocytosine.
Haeberli P, Berger I, Pallan PS, Egli M
(2005) Nucleic Acids Res 33: 3965-75
MeSH Terms: Crystallography, X-Ray, Cytosine, Models, Molecular, Molecular Structure, Nucleic Acid Conformation, Oligoribonucleotides, Organophosphorus Compounds, RNA Stability, Ribonucleosides, Thermodynamics, Thionucleosides
Added March 5, 2014
0 Communities
1 Members
0 Resources
11 MeSH Terms
Structure of the 1,N(2)-propanodeoxyguanosine adduct in a three-base DNA hairpin loop derived from a palindrome in the Salmonella typhimurium hisD3052 gene.
Weisenseel JP, Reddy GR, Marnett LJ, Stone MP
(2002) Chem Res Toxicol 15: 140-52
MeSH Terms: Alcohol Oxidoreductases, Bacterial Proteins, Base Pairing, DNA Adducts, Deoxyguanosine, Genes, Bacterial, Hydrogen-Ion Concentration, Magnetic Resonance Spectroscopy, Models, Molecular, Oligoribonucleotides, Salmonella typhimurium
Added March 5, 2014
0 Communities
2 Members
0 Resources
11 MeSH Terms
Structure of an oligodeoxynucleotide containing a 1,N(2)-propanodeoxyguanosine adduct positioned in a palindrome derived from the Salmonella typhimurium hisD3052 gene: Hoogsteen pairing at pH 5.2.
Weisenseel JP, Reddy GR, Marnett LJ, Stone MP
(2002) Chem Res Toxicol 15: 127-39
MeSH Terms: Alcohol Oxidoreductases, Bacterial Proteins, Base Pairing, DNA Adducts, DNA-Binding Proteins, Deoxyguanosine, Genes, Bacterial, Hydrogen-Ion Concentration, Oligoribonucleotides, Salmonella typhimurium
Added March 5, 2014
0 Communities
2 Members
0 Resources
10 MeSH Terms