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Results: 1 to 10 of 19

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Synthesis and Characterization of Site-Specific O -Alkylguanine DNA-Alkyl Transferase-Oligonucleotide Crosslinks.
Ghodke PP, Albertolle ME, Johnson KM, Guengerich FP
(2019) Curr Protoc Nucleic Acid Chem 76: e74
MeSH Terms: Catalysis, Catalytic Domain, Chromatography, Liquid, Copper, Cross-Linking Reagents, Escherichia coli, O(6)-Methylguanine-DNA Methyltransferase, Oligonucleotides, Polymerization, Tandem Mass Spectrometry, Templates, Genetic, Trypsin
Added March 3, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
In vivo roles of conjugation with glutathione and O6-alkylguanine DNA-alkyltransferase in the mutagenicity of the bis-electrophiles 1,2-dibromoethane and 1,2,3,4-diepoxybutane in mice.
Cho SH, Guengerich FP
(2013) Chem Res Toxicol 26: 1765-74
MeSH Terms: Animals, Butadienes, Buthionine Sulfoximine, Chromatography, High Pressure Liquid, DNA Adducts, DNA Mutational Analysis, Epoxy Compounds, Ethylene Dibromide, Glutathione, Glutathione Transferase, Guanine, Liver, Male, Mice, Mice, Transgenic, Mutagenicity Tests, Mutation, Mutation Rate, O(6)-Methylguanine-DNA Methyltransferase, Spectrometry, Mass, Electrospray Ionization
Added March 7, 2014
0 Communities
1 Members
0 Resources
20 MeSH Terms
Detection and characterization of 1,2-dibromoethane-derived DNA crosslinks formed with O(6) -alkylguanine-DNA alkyltransferase.
Chowdhury G, Cho SH, Pegg AE, Guengerich FP
(2013) Angew Chem Int Ed Engl 52: 12879-82
MeSH Terms: Animals, DNA, DNA Adducts, DNA Damage, Humans, Hydrogenation, Mutation, O(6)-Methylguanine-DNA Methyltransferase
Added March 7, 2014
0 Communities
1 Members
0 Resources
8 MeSH Terms
Reactions of glyceraldehyde 3-phosphate dehydrogenase sulfhydryl groups with bis-electrophiles produce DNA-protein cross-links but not mutations.
Loecken EM, Guengerich FP
(2008) Chem Res Toxicol 21: 453-8
MeSH Terms: Cell Survival, Cross-Linking Reagents, DNA, Environmental Pollutants, Epoxy Compounds, Escherichia coli, Ethylene Dibromide, Glyceraldehyde-3-Phosphate Dehydrogenases, Humans, Mutagens, Mutation, O(6)-Methylguanine-DNA Methyltransferase, Recombinant Proteins, Sulfhydryl Compounds
Added March 5, 2014
0 Communities
1 Members
0 Resources
14 MeSH Terms
Effect of alterations of key active site residues in O6-alkylguanine-DNA Alkyltransferase on its ability to modulate the genotoxicity of 1,2-dibromoethane.
Liu L, Watanabe K, Fang Q, Williams KM, Guengerich FP, Pegg AE
(2007) Chem Res Toxicol 20: 155-63
MeSH Terms: Binding Sites, Chromatography, High Pressure Liquid, Electrophoresis, Polyacrylamide Gel, Escherichia coli, Ethylene Dibromide, Half-Life, Mutagens, O(6)-Methylguanine-DNA Methyltransferase, Point Mutation, Spectrometry, Mass, Electrospray Ionization
Added March 26, 2014
0 Communities
1 Members
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10 MeSH Terms
Promoter methylation status of the MGMT, hMLH1, and CDKN2A/p16 genes in non-neoplastic mucosa of patients with and without colorectal adenomas.
Ye C, Shrubsole MJ, Cai Q, Ness R, Grady WM, Smalley W, Cai H, Washington K, Zheng W
(2006) Oncol Rep 16: 429-35
MeSH Terms: Adaptor Proteins, Signal Transducing, Adenoma, Aged, Carrier Proteins, Colorectal Neoplasms, CpG Islands, DNA Methylation, Epigenesis, Genetic, Female, Genes, p16, Humans, Intestinal Mucosa, Male, Middle Aged, MutL Protein Homolog 1, Nuclear Proteins, O(6)-Methylguanine-DNA Methyltransferase, Promoter Regions, Genetic
Added March 5, 2014
0 Communities
3 Members
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18 MeSH Terms
Phase II trial of the O6-alkylguanine DNA alkyltransferase inhibitor O6-benzylguanine and 1,3-bis(2-chloroethyl)-1-nitrosourea in advanced melanoma.
Gajewski TF, Sosman J, Gerson SL, Liu L, Dolan E, Lin S, Vokes EE
(2005) Clin Cancer Res 11: 7861-5
MeSH Terms: Adult, Aged, Aged, 80 and over, Antineoplastic Agents, Antineoplastic Agents, Alkylating, Antineoplastic Combined Chemotherapy Protocols, Carbon Monoxide, Carmustine, Cohort Studies, Disease Progression, Female, Guanine, Humans, Leukocytes, Mononuclear, Male, Melanoma, Middle Aged, Neoplasm Metastasis, O(6)-Methylguanine-DNA Methyltransferase, Time Factors, Treatment Outcome
Added March 5, 2014
0 Communities
1 Members
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21 MeSH Terms
Kinetic analysis of steps in the repair of damaged DNA by human O6-alkylguanine-DNA alkyltransferase.
Zang H, Fang Q, Pegg AE, Guengerich FP
(2005) J Biol Chem 280: 30873-81
MeSH Terms: Base Sequence, DNA, DNA Damage, DNA Repair, Deoxyguanosine, Guanosine, Humans, Molecular Structure, O(6)-Methylguanine-DNA Methyltransferase, Oligodeoxyribonucleotides
Added March 5, 2014
0 Communities
1 Members
0 Resources
10 MeSH Terms
Aberrantly methylated CDKN2A, MGMT, and MLH1 in colon polyps and in fecal DNA from patients with colorectal polyps.
Petko Z, Ghiassi M, Shuber A, Gorham J, Smalley W, Washington MK, Schultenover S, Gautam S, Markowitz SD, Grady WM
(2005) Clin Cancer Res 11: 1203-9
MeSH Terms: Adaptor Proteins, Signal Transducing, Adenoma, Biomarkers, Tumor, Carrier Proteins, Cell Line, Tumor, Colonic Polyps, Colorectal Neoplasms, CpG Islands, Cyclin-Dependent Kinase Inhibitor p16, DNA Methylation, DNA, Neoplasm, Feces, Humans, Hyperplasia, MutL Protein Homolog 1, Neoplasm Proteins, Nuclear Proteins, O(6)-Methylguanine-DNA Methyltransferase
Added March 5, 2014
0 Communities
1 Members
0 Resources
18 MeSH Terms
Principles of covalent binding of reactive metabolites and examples of activation of bis-electrophiles by conjugation.
Guengerich FP
(2005) Arch Biochem Biophys 433: 369-78
MeSH Terms: Aflatoxin B1, Animals, Biotransformation, Butadienes, Cross-Linking Reagents, DNA, DNA Adducts, DNA Damage, DNA Repair, Dose-Response Relationship, Drug, Enzyme Activation, Escherichia coli, Ethylene Dibromide, Forecasting, Genes, Bacterial, Glutathione, Half-Life, Humans, Hydrolysis, Kinetics, Lysine, Models, Chemical, Molecular Structure, Mutagenicity Tests, Mutagens, Mutation, O(6)-Methylguanine-DNA Methyltransferase, Oxidation-Reduction, Salmonella typhimurium, Signal Transduction, Tetrachloroethylene, Trichloroethylene
Added March 5, 2014
0 Communities
1 Members
0 Resources
32 MeSH Terms