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Hdac3 is essential for the maintenance of chromatin structure and genome stability.
Bhaskara S, Knutson SK, Jiang G, Chandrasekharan MB, Wilson AJ, Zheng S, Yenamandra A, Locke K, Yuan JL, Bonine-Summers AR, Wells CE, Kaiser JF, Washington MK, Zhao Z, Wagner FF, Sun ZW, Xia F, Holson EB, Khabele D, Hiebert SW
(2010) Cancer Cell 18: 436-47
MeSH Terms: Acetylation, Animals, Carcinoma, Hepatocellular, Cell Line, Tumor, Chromatin, Chromatin Assembly and Disassembly, DNA Damage, DNA Repair, DNA Replication, Down-Regulation, Gene Expression Regulation, Neoplastic, Genomic Instability, Histone Deacetylases, Histones, Humans, Liver Neoplasms, Experimental, Mice, Nuclear Receptor Co-Repressor 1, Nuclear Receptor Co-Repressor 2, RNA Interference, RNA, Messenger, S Phase
Added November 4, 2012
3 Communities
5 Members
0 Resources
22 MeSH Terms
Mtgr1 is a transcriptional corepressor that is required for maintenance of the secretory cell lineage in the small intestine.
Amann JM, Chyla BJ, Ellis TC, Martinez A, Moore AC, Franklin JL, McGhee L, Meyers S, Ohm JE, Luce KS, Ouelette AJ, Washington MK, Thompson MA, King D, Gautam S, Coffey RJ, Whitehead RH, Hiebert SW
(2005) Mol Cell Biol 25: 9576-85
MeSH Terms: Animals, Cell Line, Cell Lineage, Chlorocebus aethiops, Enteroendocrine Cells, Goblet Cells, Histone Deacetylases, Humans, Intestine, Small, Mice, Nuclear Proteins, Nuclear Receptor Co-Repressor 1, Paneth Cells, Phosphoproteins, Protein Binding, Repressor Proteins, Sin3 Histone Deacetylase and Corepressor Complex, Transcription, Genetic
Added August 13, 2010
2 Communities
4 Members
0 Resources
18 MeSH Terms
N-CoR mediates DNA methylation-dependent repression through a methyl CpG binding protein Kaiso.
Yoon HG, Chan DW, Reynolds AB, Qin J, Wong J
(2003) Mol Cell 12: 723-34
MeSH Terms: Animals, Carrier Proteins, CpG Islands, DNA Methylation, DNA-Binding Proteins, DNA-Cytosine Methylases, Eukaryotic Cells, Genes, Regulator, HeLa Cells, Histone Deacetylases, Histones, Humans, Lysine, Nuclear Proteins, Nuclear Receptor Co-Repressor 1, Promoter Regions, Genetic, Repressor Proteins, Transcription Factors
Added March 5, 2014
1 Communities
1 Members
0 Resources
18 MeSH Terms
ETO, a target of t(8;21) in acute leukemia, makes distinct contacts with multiple histone deacetylases and binds mSin3A through its oligomerization domain.
Amann JM, Nip J, Strom DK, Lutterbach B, Harada H, Lenny N, Downing JR, Meyers S, Hiebert SW
(2001) Mol Cell Biol 21: 6470-83
MeSH Terms: Amino Acid Sequence, Animals, Binding Sites, Cell Line, Core Binding Factor Alpha 2 Subunit, DNA-Binding Proteins, Enzyme Inhibitors, Histone Deacetylase Inhibitors, Histone Deacetylases, Hydroxamic Acids, Leukemia, Myelomonocytic, Acute, Mice, Models, Genetic, Molecular Sequence Data, Nuclear Proteins, Nuclear Receptor Co-Repressor 1, Oncogene Proteins, Fusion, Protein Structure, Tertiary, Proto-Oncogene Proteins, RUNX1 Translocation Partner 1 Protein, Repressor Proteins, Sequence Homology, Amino Acid, Sin3 Histone Deacetylase and Corepressor Complex, Transcription Factors, Transcription, Genetic, Translocation, Genetic
Added June 10, 2010
1 Communities
1 Members
0 Resources
26 MeSH Terms
TEL contacts multiple co-repressors and specifically associates with histone deacetylase-3.
Wang L, Hiebert SW
(2001) Oncogene 20: 3716-25
MeSH Terms: 3T3 Cells, Acetylation, Animals, Binding Sites, COS Cells, Chlorocebus aethiops, Chromosome Mapping, DNA-Binding Proteins, Genes, Tumor Suppressor, Histone Deacetylases, Histones, Matrix Metalloproteinase 3, Mice, Mutagenesis, Nuclear Proteins, Nuclear Receptor Co-Repressor 1, Promoter Regions, Genetic, Proto-Oncogene Proteins c-ets, Repressor Proteins, Sin3 Histone Deacetylase and Corepressor Complex, Transcription Factors
Added June 10, 2010
1 Communities
1 Members
0 Resources
21 MeSH Terms
ETO, a target of t(8;21) in acute leukemia, interacts with the N-CoR and mSin3 corepressors.
Lutterbach B, Westendorf JJ, Linggi B, Patten A, Moniwa M, Davie JR, Huynh KD, Bardwell VJ, Lavinsky RM, Rosenfeld MG, Glass C, Seto E, Hiebert SW
(1998) Mol Cell Biol 18: 7176-84
MeSH Terms: Cell Line, Chromosomes, Human, Pair 21, Chromosomes, Human, Pair 8, Core Binding Factor Alpha 2 Subunit, DNA-Binding Proteins, Histone Deacetylases, Humans, Leukemia, Myeloid, Nuclear Proteins, Nuclear Receptor Co-Repressor 1, Precipitin Tests, Proto-Oncogene Proteins, RUNX1 Translocation Partner 1 Protein, Recombinant Fusion Proteins, Repressor Proteins, Saccharomyces cerevisiae Proteins, Transcription Factors, Translocation, Genetic
Added June 10, 2010
1 Communities
1 Members
0 Resources
18 MeSH Terms