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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 7 of 7

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Identification of human liver cytochrome P-450 3A4 as the enzyme responsible for fentanyl and sufentanil N-dealkylation.
Tateishi T, Krivoruk Y, Ueng YF, Wood AJ, Guengerich FP, Wood M
(1996) Anesth Analg 82: 167-72
MeSH Terms: Analgesics, Opioid, Animals, Antibodies, Antibody Specificity, Cytochrome P-450 CYP3A, Cytochrome P-450 Enzyme Inhibitors, Cytochrome P-450 Enzyme System, Dealkylation, Enzyme Inhibitors, Erythromycin, Fentanyl, Humans, Kinetics, Liver, Microsomes, Liver, Mixed Function Oxygenases, Norpregnenes, Rabbits, Sufentanil, Troleandomycin
Added March 5, 2014
0 Communities
1 Members
0 Resources
20 MeSH Terms
Oxidation of the antihistaminic drug terfenadine in human liver microsomes. Role of cytochrome P-450 3A(4) in N-dealkylation and C-hydroxylation.
Yun CH, Okerholm RA, Guengerich FP
(1993) Drug Metab Dispos 21: 403-9
MeSH Terms: Contraceptives, Oral, Cytochrome P-450 CYP2E1, Cytochrome P-450 Enzyme Inhibitors, Cytochrome P-450 Enzyme System, Dealkylation, Humans, Hydroxylation, In Vitro Techniques, Microsomes, Liver, Mixed Function Oxygenases, NADP, Norpregnenes, Oxidation-Reduction, Stereoisomerism, Terfenadine
Added March 5, 2014
0 Communities
1 Members
0 Resources
15 MeSH Terms
Inhibition of oral contraceptive steroid-metabolizing enzymes by steroids and drugs.
Guengerich FP
(1990) Am J Obstet Gynecol 163: 2159-63
MeSH Terms: Animals, Contraceptives, Oral, Hormonal, Cytochrome P-450 CYP1A1, Cytochrome P-450 Enzyme Inhibitors, Ethinyl Estradiol, Humans, Hydroxylation, Norpregnenes, Progestins, Steroid Hydroxylases, Steroids
Added March 5, 2014
0 Communities
1 Members
0 Resources
11 MeSH Terms
Mechanism-based inactivation of human liver microsomal cytochrome P-450 IIIA4 by gestodene.
Guengerich FP
(1990) Chem Res Toxicol 3: 363-71
MeSH Terms: Contraceptives, Oral, Cytochrome P-450 Enzyme Inhibitors, Ethinyl Estradiol, Humans, Hydroxylation, Microsomes, Liver, Nifedipine, Norpregnenes, Oxidation-Reduction, Structure-Activity Relationship
Added March 5, 2014
0 Communities
1 Members
0 Resources
10 MeSH Terms
Oxidation of dihydropyridine calcium channel blockers and analogues by human liver cytochrome P-450 IIIA4.
Guengerich FP, Brian WR, Iwasaki M, Sari MA, Bäärnhielm C, Berntsson P
(1991) J Med Chem 34: 1838-44
MeSH Terms: Calcium Channel Blockers, Chromatography, High Pressure Liquid, Cimetidine, Cytochrome P-450 Enzyme System, Dihydropyridines, Felodipine, Humans, Kinetics, Microsomes, Liver, Nifedipine, Norpregnenes, Oxidation-Reduction
Added March 5, 2014
0 Communities
1 Members
0 Resources
12 MeSH Terms
Human liver microsomal N-hydroxylation of dapsone by cytochrome P-4503A4.
Fleming CM, Branch RA, Wilkinson GR, Guengerich FP
(1992) Mol Pharmacol 41: 975-80
MeSH Terms: Antibodies, Benzoflavones, Cytochrome P-450 Enzyme System, Humans, Hydroxylation, Isoenzymes, Kinetics, Microsomes, Liver, Norpregnenes, Troleandomycin
Added March 5, 2014
0 Communities
1 Members
0 Resources
10 MeSH Terms
Roles of human liver cytochrome P4502C and 3A enzymes in the 3-hydroxylation of benzo(a)pyrene.
Yun CH, Shimada T, Guengerich FP
(1992) Cancer Res 52: 1868-74
MeSH Terms: Antibodies, Benzo(a)pyrene, Benzoflavones, Cytochrome P-450 Enzyme System, Gene Expression, Humans, Hydroxylation, Isoenzymes, Kinetics, Liver, Microsomes, Liver, Norpregnenes, Recombinant Proteins, Saccharomyces cerevisiae, Sulfaphenazole
Added March 5, 2014
0 Communities
1 Members
0 Resources
15 MeSH Terms