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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 10

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M-positive allosteric modulators lacking agonist activity provide the optimal profile for enhancing cognition.
Moran SP, Dickerson JW, Cho HP, Xiang Z, Maksymetz J, Remke DH, Lv X, Doyle CA, Rajan DH, Niswender CM, Engers DW, Lindsley CW, Rook JM, Conn PJ
(2018) Neuropsychopharmacology 43: 1763-1771
MeSH Terms: Allosteric Regulation, Animals, CHO Cells, Cholinergic Agents, Cricetulus, Excitatory Postsynaptic Potentials, Male, Mice, Inbred C57BL, Nootropic Agents, Prefrontal Cortex, Pyramidal Cells, Rats, Rats, Sprague-Dawley, Receptor, Muscarinic M1, Recognition, Psychology, Tissue Culture Techniques
Added March 3, 2020
0 Communities
2 Members
0 Resources
MeSH Terms
Beyond Acetylcholinesterase Inhibitors: Novel Cholinergic Treatments for Alzheimer's Disease.
Kamkwalala AR, Newhouse PA
(2017) Curr Alzheimer Res 14: 377-392
MeSH Terms: Alzheimer Disease, Animals, Cholinergic Agents, Humans, Neuroprotective Agents, Nootropic Agents
Added March 3, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
Prefrontal Cortex-Mediated Impairments in a Genetic Model of NMDA Receptor Hypofunction Are Reversed by the Novel M PAM VU6004256.
Grannan MD, Mielnik CA, Moran SP, Gould RW, Ball J, Lu Z, Bubser M, Ramsey AJ, Abe M, Cho HP, Nance KD, Blobaum AL, Niswender CM, Conn PJ, Lindsley CW, Jones CK
(2016) ACS Chem Neurosci 7: 1706-1716
MeSH Terms: Action Potentials, Animals, Cholinergic Agents, Cognition Disorders, Conditioning, Psychological, Disease Models, Animal, Drug Evaluation, Preclinical, Fear, Gene Knockdown Techniques, Heterocyclic Compounds, 4 or More Rings, Long-Term Synaptic Depression, Male, Mice, 129 Strain, Mice, Inbred C57BL, Mice, Transgenic, Motor Activity, Nerve Tissue Proteins, Nootropic Agents, Prefrontal Cortex, Pyramidal Cells, Receptors, N-Methyl-D-Aspartate, Recognition, Psychology, Tissue Culture Techniques
Added April 6, 2017
0 Communities
3 Members
0 Resources
23 MeSH Terms
N-aryl piperazine metabotropic glutamate receptor 5 positive allosteric modulators possess efficacy in preclinical models of NMDA hypofunction and cognitive enhancement.
Gregory KJ, Herman EJ, Ramsey AJ, Hammond AS, Byun NE, Stauffer SR, Manka JT, Jadhav S, Bridges TM, Weaver CD, Niswender CM, Steckler T, Drinkenburg WH, Ahnaou A, Lavreysen H, Macdonald GJ, Bartolomé JM, Mackie C, Hrupka BJ, Caron MG, Daigle TL, Lindsley CW, Conn PJ, Jones CK
(2013) J Pharmacol Exp Ther 347: 438-57
MeSH Terms: Allosteric Regulation, Animals, Antipsychotic Agents, Dose-Response Relationship, Drug, Drug Evaluation, Preclinical, HEK293 Cells, Humans, Hyperkinesis, Male, Maze Learning, Memory, Short-Term, Mice, Mice, Knockout, Motor Activity, Nootropic Agents, Piperazines, Rats, Rats, Sprague-Dawley, Receptor, Metabotropic Glutamate 5, Receptors, N-Methyl-D-Aspartate, Schizophrenia, Transfection
Added February 16, 2015
0 Communities
5 Members
0 Resources
22 MeSH Terms
Muscarinic receptor pharmacology and circuitry for the modulation of cognition.
Bubser M, Byun N, Wood MR, Jones CK
(2012) Handb Exp Pharmacol : 121-66
MeSH Terms: Acetylcholine, Animals, Brain, Cognition, Cognition Disorders, Humans, Muscarinic Agonists, Muscarinic Antagonists, Nootropic Agents, Receptors, Muscarinic, Signal Transduction
Added March 14, 2018
0 Communities
2 Members
0 Resources
11 MeSH Terms
The cholinergic hypothesis of cognitive aging revisited again: cholinergic functional compensation.
Dumas JA, Newhouse PA
(2011) Pharmacol Biochem Behav 99: 254-61
MeSH Terms: Acetylcholine, Aging, Alzheimer Disease, Cognition, Cognition Disorders, Humans, Models, Neurological, Models, Psychological, Nootropic Agents, Receptors, Cholinergic
Added March 3, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
The effect of donepezil treatment on cardiovascular mortality.
Sato K, Urbano R, Yu C, Yamasaki F, Sato T, Jordan J, Robertson D, Diedrich A
(2010) Clin Pharmacol Ther 88: 335-8
MeSH Terms: Aged, Aged, 80 and over, Alzheimer Disease, Cardiovascular Diseases, Cholinesterase Inhibitors, Cohort Studies, Dementia, Vascular, Donepezil, Female, Follow-Up Studies, Humans, Indans, Male, Nootropic Agents, Piperidines, Proportional Hazards Models, Retrospective Studies
Added December 10, 2013
0 Communities
1 Members
0 Resources
17 MeSH Terms
Ascorbic acid attenuates scopolamine-induced spatial learning deficits in the water maze.
Harrison FE, Hosseini AH, Dawes SM, Weaver S, May JM
(2009) Behav Brain Res 205: 550-8
MeSH Terms: Acetylcholinesterase, Animals, Ascorbic Acid, Cerebral Cortex, Corpus Striatum, Escape Reaction, Female, Learning Disabilities, Liver, Locomotion, Male, Maze Learning, Mice, Mice, Inbred Strains, Nootropic Agents, Prosencephalon, Scopolamine, Space Perception, Time Factors
Added December 10, 2013
0 Communities
1 Members
0 Resources
19 MeSH Terms
Ameliorating effects of preadolescent aniracetam treatment on prenatal ethanol-induced impairment in AMPA receptor activity.
Wijayawardhane N, Shonesy BC, Vaithianathan T, Pandiella N, Vaglenova J, Breese CR, Dityatev A, Suppiramaniam V
(2008) Neurobiol Dis 29: 81-91
MeSH Terms: Animals, Animals, Newborn, Central Nervous System Depressants, Drug Interactions, Ethanol, Excitatory Amino Acid Agents, Excitatory Postsynaptic Potentials, Female, Hippocampus, In Vitro Techniques, Ion Channel Gating, Neurons, Nootropic Agents, Patch-Clamp Techniques, Pregnancy, Prenatal Exposure Delayed Effects, Pyrrolidinones, Rats, Rats, Sprague-Dawley, Receptors, AMPA, Time Factors
Added July 2, 2013
0 Communities
1 Members
0 Resources
21 MeSH Terms
Postnatal aniracetam treatment improves prenatal ethanol induced attenuation of AMPA receptor-mediated synaptic transmission.
Wijayawardhane N, Shonesy BC, Vaglenova J, Vaithianathan T, Carpenter M, Breese CR, Dityatev A, Suppiramaniam V
(2007) Neurobiol Dis 26: 696-706
MeSH Terms: Alcohol-Induced Disorders, Nervous System, Animals, Animals, Newborn, Central Nervous System Depressants, Ethanol, Female, Glutamic Acid, Hippocampus, Male, Neural Pathways, Nootropic Agents, Organ Culture Techniques, Patch-Clamp Techniques, Pregnancy, Prenatal Exposure Delayed Effects, Pyramidal Cells, Pyrrolidinones, Rats, Rats, Sprague-Dawley, Receptors, AMPA, Synaptic Transmission, Treatment Outcome
Added July 2, 2013
0 Communities
1 Members
0 Resources
22 MeSH Terms