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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 53

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The antifungal drug isavuconazole inhibits the replication of human cytomegalovirus (HCMV) and acts synergistically with anti-HCMV drugs.
Mercorelli B, Celegato M, Luganini A, Gribaudo G, Lepesheva GI, Loregian A
(2021) Antiviral Res 189: 105062
MeSH Terms: Antifungal Agents, Antiviral Agents, Cell Line, Cytomegalovirus, Cytomegalovirus Infections, Drug Repositioning, Drug Resistance, Viral, Drug Synergism, Drug Therapy, Combination, Humans, Nitriles, Pyridines, Sterol 14-Demethylase, Triazoles, Virus Replication
Added July 2, 2021
0 Communities
1 Members
0 Resources
15 MeSH Terms
The delta isoform of phosphatidylinositol-3-kinase predominates in chronic myelomonocytic leukemia and can be targeted effectively with umbralisib and ruxolitinib.
Villaume MT, Arrate MP, Ramsey HE, Sunthankar KI, Jenkins MT, Moyo TK, Smith BN, Fischer MA, Childress MA, Gorska AE, Ferrell PB, Savona MR
(2021) Exp Hematol 97: 57-65.e5
MeSH Terms: Cell Line, Tumor, Cell Survival, Class I Phosphatidylinositol 3-Kinases, Drug Synergism, Heterocyclic Compounds, 4 or More Rings, Humans, Leukemia, Myelomonocytic, Chronic, Molecular Targeted Therapy, Nitriles, Phosphoinositide-3 Kinase Inhibitors, Pyrazoles, Pyrimidines
Added September 1, 2022
0 Communities
1 Members
0 Resources
MeSH Terms
Hyperoxia Injury in the Developing Lung Is Mediated by Mesenchymal Expression of Wnt5A.
Sucre JMS, Vickers KC, Benjamin JT, Plosa EJ, Jetter CS, Cutrone A, Ransom M, Anderson Z, Sheng Q, Fensterheim BA, Ambalavanan N, Millis B, Lee E, Zijlstra A, Königshoff M, Blackwell TS, Guttentag SH
(2020) Am J Respir Crit Care Med 201: 1249-1262
MeSH Terms: Alveolar Epithelial Cells, Animals, Bronchopulmonary Dysplasia, Coculture Techniques, Fibroblasts, Gene Expression Profiling, Gene Expression Regulation, Developmental, Humans, Hyperoxia, In Situ Hybridization, Lung, Mesenchymal Stem Cells, Mice, Microscopy, Confocal, NF-kappa B, Nitriles, Organ Culture Techniques, Real-Time Polymerase Chain Reaction, Sulfones, Wnt-5a Protein
Added February 6, 2020
0 Communities
3 Members
0 Resources
20 MeSH Terms
TBCRC 032 IB/II Multicenter Study: Molecular Insights to AR Antagonist and PI3K Inhibitor Efficacy in Patients with AR Metastatic Triple-Negative Breast Cancer.
Lehmann BD, Abramson VG, Sanders ME, Mayer EL, Haddad TC, Nanda R, Van Poznak C, Storniolo AM, Nangia JR, Gonzalez-Ericsson PI, Sanchez V, Johnson KN, Abramson RG, Chen SC, Shyr Y, Arteaga CL, Wolff AC, Pietenpol JA, Translational Breast Cancer Research Consortium
(2020) Clin Cancer Res 26: 2111-2123
MeSH Terms: Androgen Receptor Antagonists, Antineoplastic Combined Chemotherapy Protocols, Benzamides, Class I Phosphatidylinositol 3-Kinases, Female, Humans, Imidazoles, Middle Aged, Neoplasm Metastasis, Nitriles, Oxazepines, Phenylthiohydantoin, Protein Kinase Inhibitors, Receptors, Androgen, Survival Rate, Triple Negative Breast Neoplasms
Added March 30, 2020
0 Communities
1 Members
0 Resources
16 MeSH Terms
Heart failure and atrial tachyarrhythmia on abiraterone: A pharmacovigilance study.
Bretagne M, Lebrun-Vignes B, Pariente A, Shaffer CM, Malouf GG, Dureau P, Potey C, Funck-Brentano C, Roden DM, Moslehi JJ, Salem JE
(2020) Arch Cardiovasc Dis 113: 9-21
MeSH Terms: Adverse Drug Reaction Reporting Systems, Aged, Aged, 80 and over, Androgen Antagonists, Androstenes, Antineoplastic Agents, Hormonal, Benzamides, Cardiotoxicity, Databases, Factual, Heart Failure, Humans, Male, Middle Aged, Nitriles, Pharmacovigilance, Phenylthiohydantoin, Prostatic Neoplasms, Retrospective Studies, Risk Assessment, Risk Factors, Tachycardia, Supraventricular, Time Factors
Added November 12, 2019
0 Communities
2 Members
0 Resources
22 MeSH Terms
Androgenic Effects on Ventricular Repolarization: A Translational Study From the International Pharmacovigilance Database to iPSC-Cardiomyocytes.
Salem JE, Yang T, Moslehi JJ, Waintraub X, Gandjbakhch E, Bachelot A, Hidden-Lucet F, Hulot JS, Knollmann BC, Lebrun-Vignes B, Funck-Brentano C, Glazer AM, Roden DM
(2019) Circulation 140: 1070-1080
MeSH Terms: Androgens, Antineoplastic Agents, Benzamides, Cell Differentiation, Cells, Cultured, Databases, Factual, Humans, Hypogonadism, Induced Pluripotent Stem Cells, International Cooperation, Long QT Syndrome, Male, Myocytes, Cardiac, Nitriles, Pharmacovigilance, Phenylthiohydantoin, Risk, Torsades de Pointes, Translational Research, Biomedical
Added November 12, 2019
0 Communities
2 Members
0 Resources
19 MeSH Terms
Radiosensitization by enzalutamide for human prostate cancer is mediated through the DNA damage repair pathway.
Sekhar KR, Wang J, Freeman ML, Kirschner AN
(2019) PLoS One 14: e0214670
MeSH Terms: Aged, Animals, Benzamides, Cell Line, Tumor, Cell Proliferation, DNA Damage, DNA Repair, Drug Resistance, Neoplasm, Humans, Male, Mice, Mice, Nude, Mice, Transgenic, Nitriles, Phenylthiohydantoin, Prostatic Neoplasms, Prostatic Neoplasms, Castration-Resistant, Radiation Tolerance, Radiation-Sensitizing Agents, Signal Transduction, Xenograft Model Antitumor Assays
Added April 2, 2019
0 Communities
2 Members
0 Resources
21 MeSH Terms
Vildagliptin ameliorates pulmonary fibrosis in lipopolysaccharide-induced lung injury by inhibiting endothelial-to-mesenchymal transition.
Suzuki T, Tada Y, Gladson S, Nishimura R, Shimomura I, Karasawa S, Tatsumi K, West J
(2017) Respir Res 18: 177
MeSH Terms: Adamantane, Animals, Dipeptidyl-Peptidase IV Inhibitors, Epithelial-Mesenchymal Transition, Lipopolysaccharides, Lung Injury, Male, Mice, Mice, Inbred C57BL, Nitriles, Pulmonary Fibrosis, Pyrrolidines, Vildagliptin
Added April 2, 2019
0 Communities
1 Members
0 Resources
MeSH Terms
Oestrogen inhibition reverses pulmonary arterial hypertension and associated metabolic defects.
Chen X, Austin ED, Talati M, Fessel JP, Farber-Eger EH, Brittain EL, Hemnes AR, Loyd JE, West J
(2017) Eur Respir J 50:
MeSH Terms: Anastrozole, Animals, Bone Morphogenetic Protein Receptors, Type II, Disease Models, Animal, Echocardiography, Estradiol, Estrogen Antagonists, Female, Fulvestrant, Hemodynamics, Humans, Hypertension, Pulmonary, Insulin Resistance, Lung, Mice, Mice, Knockout, Mutation, Nitriles, Signal Transduction, Tamoxifen, Triazoles
Added March 14, 2018
0 Communities
3 Members
0 Resources
21 MeSH Terms
A Phase Ib Study of Alpelisib (BYL719), a PI3Kα-Specific Inhibitor, with Letrozole in ER+/HER2- Metastatic Breast Cancer.
Mayer IA, Abramson VG, Formisano L, Balko JM, Estrada MV, Sanders ME, Juric D, Solit D, Berger MF, Won HH, Li Y, Cantley LC, Winer E, Arteaga CL
(2017) Clin Cancer Res 23: 26-34
MeSH Terms: Adult, Aged, Antineoplastic Combined Chemotherapy Protocols, Aromatase Inhibitors, Biomarkers, Tumor, Breast Neoplasms, Cell Line, Tumor, DNA Mutational Analysis, Female, Humans, In Situ Hybridization, Fluorescence, Letrozole, Maximum Tolerated Dose, Middle Aged, Mutation, Neoplasm Metastasis, Neoplasm Staging, Nitriles, Phosphatidylinositol 3-Kinases, Phosphoinositide-3 Kinase Inhibitors, Receptor, ErbB-2, Receptor, Fibroblast Growth Factor, Type 1, Receptors, Estrogen, Thiazoles, Treatment Outcome, Triazoles
Added April 6, 2017
0 Communities
1 Members
0 Resources
26 MeSH Terms