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Results: 1 to 10 of 51

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Increased breadth of HIV-1 neutralization achieved by diverse antibody clones each with limited neutralization breadth.
Chukwuma VU, Kose N, Sather DN, Sapparapu G, Falk R, King H, Singh V, Lampley R, Malherbe DC, Ditto NT, Sullivan JT, Barnes T, Doranz BJ, Labranche CC, Montefiori DC, Kalams SA, Haigwood NL, Crowe JE
(2018) PLoS One 13: e0209437
MeSH Terms: Antibodies, Neutralizing, Antibody Diversity, B-Lymphocytes, Cells, Cultured, Epitope Mapping, Epitopes, HIV Antibodies, HIV Infections, HIV-1, Humans, Hybridomas, Neutralization Tests, env Gene Products, Human Immunodeficiency Virus
Added March 31, 2019
0 Communities
1 Members
0 Resources
13 MeSH Terms
Surface-Matrix Screening Identifies Semi-specific Interactions that Improve Potency of a Near Pan-reactive HIV-1-Neutralizing Antibody.
Kwon YD, Chuang GY, Zhang B, Bailer RT, Doria-Rose NA, Gindin TS, Lin B, Louder MK, McKee K, O'Dell S, Pegu A, Schmidt SD, Asokan M, Chen X, Choe M, Georgiev IS, Jin V, Pancera M, Rawi R, Wang K, Chaudhuri R, Kueltzo LA, Manceva SD, Todd JP, Scorpio DG, Kim M, Reinherz EL, Wagh K, Korber BM, Connors M, Shapiro L, Mascola JR, Kwong PD
(2018) Cell Rep 22: 1798-1809
MeSH Terms: Antibodies, Neutralizing, Cell Membrane, HIV Antibodies, HIV Envelope Protein gp41, HIV-1, Half-Life, Humans, Neutralization Tests, Polysaccharides, Protein Binding
Added March 14, 2018
0 Communities
1 Members
0 Resources
10 MeSH Terms
Structure-function characterization of three human antibodies targeting the vaccinia virus adhesion molecule D8.
Matho MH, Schlossman A, Gilchuk IM, Miller G, Mikulski Z, Hupfer M, Wang J, Bitra A, Meng X, Xiang Y, Kaever T, Doukov T, Ley K, Crotty S, Peters B, Hsieh-Wilson LC, Crowe JE, Zajonc DM
(2018) J Biol Chem 293: 390-401
MeSH Terms: Antibodies, Antibodies, Monoclonal, Antibodies, Neutralizing, Antibodies, Viral, Antibody Formation, Antigens, Viral, Cell Adhesion Molecules, Crystallography, X-Ray, Enzyme-Linked Immunosorbent Assay, Epitopes, Humans, Neutralization Tests, Protein Binding, Structure-Activity Relationship, Vaccinia virus, Viral Envelope Proteins
Added March 14, 2018
0 Communities
1 Members
0 Resources
16 MeSH Terms
Broadly neutralizing antibodies targeting the HIV-1 envelope V2 apex confer protection against a clade C SHIV challenge.
Julg B, Tartaglia LJ, Keele BF, Wagh K, Pegu A, Sok D, Abbink P, Schmidt SD, Wang K, Chen X, Joyce MG, Georgiev IS, Choe M, Kwong PD, Doria-Rose NA, Le K, Louder MK, Bailer RT, Moore PL, Korber B, Seaman MS, Abdool Karim SS, Morris L, Koup RA, Mascola JR, Burton DR, Barouch DH
(2017) Sci Transl Med 9:
MeSH Terms: Amino Acid Sequence, Animals, Antibodies, Neutralizing, CD4-Positive T-Lymphocytes, Female, HIV Envelope Protein gp120, HIV-1, Macaca mulatta, Male, Neutralization Tests, Sequence Alignment, Simian Acquired Immunodeficiency Syndrome, Simian Immunodeficiency Virus, Viral Load
Added March 14, 2018
0 Communities
1 Members
0 Resources
14 MeSH Terms
Principles of Broad and Potent Antiviral Human Antibodies: Insights for Vaccine Design.
Crowe JE
(2017) Cell Host Microbe 22: 193-206
MeSH Terms: Animals, Antibodies, Monoclonal, Antibodies, Neutralizing, Antibodies, Viral, Antigens, Viral, Antiviral Agents, Cross Reactions, Drug Design, Genes, Reporter, Humans, Immunity, Models, Molecular, Neutralization Tests, Protein Structure, Quaternary, Vaccination, Vaccines, Viral Envelope Proteins, Virus Diseases
Added March 14, 2018
0 Communities
1 Members
0 Resources
18 MeSH Terms
Mapping Polyclonal HIV-1 Antibody Responses via Next-Generation Neutralization Fingerprinting.
Doria-Rose NA, Altae-Tran HR, Roark RS, Schmidt SD, Sutton MS, Louder MK, Chuang GY, Bailer RT, Cortez V, Kong R, McKee K, O'Dell S, Wang F, Abdool Karim SS, Binley JM, Connors M, Haynes BF, Martin MA, Montefiori DC, Morris L, Overbaugh J, Kwong PD, Mascola JR, Georgiev IS
(2017) PLoS Pathog 13: e1006148
MeSH Terms: AIDS Vaccines, Algorithms, Antibody Formation, Antibody Specificity, Cohort Studies, Computer Simulation, Epitope Mapping, Epitopes, HIV Antibodies, HIV Infections, HIV-1, Humans, Neutralization Tests
Added May 3, 2017
0 Communities
1 Members
0 Resources
13 MeSH Terms
Structural Insights into Reovirus σ1 Interactions with Two Neutralizing Antibodies.
Dietrich MH, Ogden KM, Katen SP, Reiss K, Sutherland DM, Carnahan RH, Goff M, Cooper T, Dermody TS, Stehle T
(2017) J Virol 91:
MeSH Terms: Amino Acid Sequence, Animals, Antibodies, Neutralizing, Antibodies, Viral, Binding Sites, CHO Cells, Cell Line, Cricetulus, Hemagglutinin Glycoproteins, Influenza Virus, Immunoglobulin Fab Fragments, Mice, Molecular Docking Simulation, Molecular Dynamics Simulation, Neutralization Tests, Protein Binding, Protein Conformation, Protein Interaction Domains and Motifs, Reoviridae, Structure-Activity Relationship, Viral Proteins, Virus Replication
Added April 26, 2017
0 Communities
1 Members
0 Resources
21 MeSH Terms
Multiple Antibody Lineages in One Donor Target the Glycan-V3 Supersite of the HIV-1 Envelope Glycoprotein and Display a Preference for Quaternary Binding.
Longo NS, Sutton MS, Shiakolas AR, Guenaga J, Jarosinski MC, Georgiev IS, McKee K, Bailer RT, Louder MK, O'Dell S, Connors M, Wyatt RT, Mascola JR, Doria-Rose NA
(2016) J Virol 90: 10574-10586
MeSH Terms: AIDS Vaccines, Amino Acid Sequence, Antibodies, Monoclonal, Antibodies, Neutralizing, Antibody Specificity, B-Lymphocytes, Binding Sites, Cells, Cultured, Epitope Mapping, HIV Antibodies, HIV Envelope Protein gp120, HIV Infections, HIV-1, Humans, Neutralization Tests, Peptide Fragments, Protein Structure, Quaternary
Added May 3, 2017
0 Communities
1 Members
0 Resources
17 MeSH Terms
Structural basis for norovirus neutralization by an HBGA blocking human IgA antibody.
Shanker S, Czakó R, Sapparapu G, Alvarado G, Viskovska M, Sankaran B, Atmar RL, Crowe JE, Estes MK, Prasad BV
(2016) Proc Natl Acad Sci U S A 113: E5830-E5837
MeSH Terms: Amino Acid Sequence, Antibodies, Blocking, Antigens, Blood Group Antigens, Crystallography, X-Ray, Epitopes, Genotype, Humans, Immunoglobulin A, Immunoglobulin Fab Fragments, Models, Molecular, Neutralization Tests, Norovirus, Protein Domains, Viral Proteins
Added April 13, 2017
0 Communities
1 Members
0 Resources
15 MeSH Terms
Development of Human Monoclonal Antibodies Against Respiratory Syncytial Virus Using a High Efficiency Human Hybridoma Technique.
Alvarado G, Crowe JE
(2016) Methods Mol Biol 1442: 63-76
MeSH Terms: Antibodies, Monoclonal, Antibodies, Neutralizing, B-Lymphocytes, Cell Line, Cell Proliferation, Humans, Hybridomas, Lymphocyte Activation, Neutralization Tests, Respiratory Syncytial Virus, Human
Added April 13, 2017
0 Communities
1 Members
0 Resources
10 MeSH Terms