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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 38

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Structural basis of ligand binding modes at the neuropeptide Y Y receptor.
Yang Z, Han S, Keller M, Kaiser A, Bender BJ, Bosse M, Burkert K, Kögler LM, Wifling D, Bernhardt G, Plank N, Littmann T, Schmidt P, Yi C, Li B, Ye S, Zhang R, Xu B, Larhammar D, Stevens RC, Huster D, Meiler J, Zhao Q, Beck-Sickinger AG, Buschauer A, Wu B
(2018) Nature 556: 520-524
MeSH Terms: Arginine, Binding Sites, Crystallography, X-Ray, Dihydropyridines, Diphenylacetic Acids, Humans, Inositol Phosphates, Ligands, Molecular Docking Simulation, Mutant Proteins, Mutation, Neuropeptide Y, Nuclear Magnetic Resonance, Biomolecular, Phenylurea Compounds, Protein Binding, Receptors, Neuropeptide Y, Structure-Activity Relationship, Substrate Specificity
Added March 21, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
G Protein Preassembly Rescues Efficacy of W Toggle Mutations in Neuropeptide Y Receptor.
Kaiser A, Hempel C, Wanka L, Schubert M, Hamm HE, Beck-Sickinger AG
(2018) Mol Pharmacol 93: 387-401
MeSH Terms: Amino Acid Sequence, Binding Sites, Dose-Response Relationship, Drug, GTP-Binding Proteins, HEK293 Cells, Humans, Mutation, Neuropeptide Y, Protein Structure, Secondary, Receptors, Neuropeptide Y
Added March 24, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
A critical period for the trophic actions of leptin on AgRP neurons in the arcuate nucleus of the hypothalamus.
Kamitakahara A, Bouyer K, Wang CH, Simerly R
(2018) J Comp Neurol 526: 133-145
MeSH Terms: Age Factors, Agouti-Related Protein, Analysis of Variance, Animals, Animals, Newborn, Arcuate Nucleus of Hypothalamus, Axons, ELAV-Like Protein 3, Estrogen Receptor alpha, Female, Green Fluorescent Proteins, Integrases, Leptin, Male, Mice, Mice, Inbred C57BL, Mice, Transgenic, Neurons, Neuropeptide Y, Receptors, Leptin, STAT3 Transcription Factor
Added April 11, 2019
0 Communities
1 Members
0 Resources
MeSH Terms
Identification and Characterization of the First Selective Y Receptor Positive Allosteric Modulator.
Schubert M, Stichel J, Du Y, Tough IR, Sliwoski G, Meiler J, Cox HM, Weaver CD, Beck-Sickinger AG
(2017) J Med Chem 60: 7605-7612
MeSH Terms: Allosteric Regulation, Animals, Arrestins, COS Cells, Chlorocebus aethiops, Cyclohexanols, GTP-Binding Proteins, HEK293 Cells, Humans, Models, Molecular, Receptors, Neuropeptide Y, Signal Transduction
Added March 17, 2018
0 Communities
2 Members
0 Resources
12 MeSH Terms
A Deep Hydrophobic Binding Cavity is the Main Interaction for Different Y R Antagonists.
Burkert K, Zellmann T, Meier R, Kaiser A, Stichel J, Meiler J, Mittapalli GK, Roberts E, Beck-Sickinger AG
(2017) ChemMedChem 12: 75-85
MeSH Terms: Animals, Arginine, Benzazepines, Binding Sites, COS Cells, Cells, Cultured, Chlorocebus aethiops, Dose-Response Relationship, Drug, HEK293 Cells, Humans, Hydrophobic and Hydrophilic Interactions, Molecular Docking Simulation, Molecular Structure, Receptors, Neuropeptide Y, Structure-Activity Relationship
Added April 8, 2017
1 Communities
1 Members
0 Resources
15 MeSH Terms
C-terminal motif of human neuropeptide Y receptor determines internalization and arrestin recruitment.
Wanka L, Babilon S, Burkert K, Mörl K, Gurevich VV, Beck-Sickinger AG
(2017) Cell Signal 29: 233-239
MeSH Terms: Amino Acid Motifs, Amino Acid Sequence, Amino Acids, Animals, COS Cells, Chlorocebus aethiops, Endocytosis, HEK293 Cells, Humans, Mutant Proteins, Receptors, Neuropeptide Y, Reproducibility of Results, Sequence Alignment, Sequence Deletion, Structure-Activity Relationship, beta-Arrestin 2
Added March 14, 2018
0 Communities
1 Members
0 Resources
16 MeSH Terms
Discovery of Small-Molecule Modulators of the Human Y4 Receptor.
Sliwoski G, Schubert M, Stichel J, Weaver D, Beck-Sickinger AG, Meiler J
(2016) PLoS One 11: e0157146
MeSH Terms: Allosteric Regulation, Animals, COS Cells, Chlorocebus aethiops, Drug Evaluation, Preclinical, Humans, Ligands, Niclosamide, Receptors, Neuropeptide Y, Small Molecule Libraries, Structure-Activity Relationship
Added April 8, 2017
1 Communities
1 Members
0 Resources
11 MeSH Terms
Unwinding of the C-Terminal Residues of Neuropeptide Y is critical for Y₂ Receptor Binding and Activation.
Kaiser A, Müller P, Zellmann T, Scheidt HA, Thomas L, Bosse M, Meier R, Meiler J, Huster D, Beck-Sickinger AG, Schmidt P
(2015) Angew Chem Int Ed Engl 54: 7446-9
MeSH Terms: Amino Acid Sequence, Binding Sites, Humans, Molecular Docking Simulation, Molecular Sequence Data, Neuropeptide Y, Nuclear Magnetic Resonance, Biomolecular, Protein Binding, Protein Structure, Secondary, Receptors, Neuropeptide Y
Added February 5, 2016
1 Communities
2 Members
0 Resources
10 MeSH Terms
A rodent model of traumatic stress induces lasting sleep and quantitative electroencephalographic disturbances.
Nedelcovych MT, Gould RW, Zhan X, Bubser M, Gong X, Grannan M, Thompson AT, Ivarsson M, Lindsley CW, Conn PJ, Jones CK
(2015) ACS Chem Neurosci 6: 485-93
MeSH Terms: Analysis of Variance, Animals, Brain Waves, Corticosterone, Disease Models, Animal, Electroencephalography, Electromyography, Fourier Analysis, Indoles, Male, Neuropeptide Y, RNA, Messenger, Random Allocation, Rats, Rats, Sprague-Dawley, Serotonin, Sleep Wake Disorders, Stress Disorders, Post-Traumatic, Tacrolimus Binding Proteins, Time Factors
Added February 12, 2015
0 Communities
2 Members
0 Resources
20 MeSH Terms
Position and length of fatty acids strongly affect receptor selectivity pattern of human pancreatic polypeptide analogues.
Mäde V, Bellmann-Sickert K, Kaiser A, Meiler J, Beck-Sickinger AG
(2014) ChemMedChem 9: 2463-74
MeSH Terms: Amino Acid Sequence, Animals, Anti-Obesity Agents, COS Cells, Chlorocebus aethiops, Fatty Acids, Half-Life, Humans, Kinetics, Ligands, Liver, Molecular Sequence Data, Pancreatic Polypeptide, Receptors, Neuropeptide Y
Added January 24, 2015
1 Communities
1 Members
0 Resources
14 MeSH Terms