Other search tools

About this data

The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

If you have any questions or comments, please contact us.

Results: 1 to 10 of 12

Publication Record

Connections

FGFR1 signaling in hypertrophic chondrocytes is attenuated by the Ras-GAP neurofibromin during endochondral bone formation.
Karolak MR, Yang X, Elefteriou F
(2015) Hum Mol Genet 24: 2552-64
MeSH Terms: Animals, Chondrocytes, Chondrogenesis, Collagen Type II, Female, Gene Expression, Gene Knockout Techniques, Growth Plate, Hypertrophy, Male, Mice, Mice, Knockout, Neurofibromin 1, Osteoclasts, Osteogenesis, Phenotype, Phenylurea Compounds, Protein Transport, Pyrimidines, Receptor, Fibroblast Growth Factor, Type 1, Receptor, Fibroblast Growth Factor, Type 3, Signal Transduction
Added February 19, 2015
0 Communities
1 Members
0 Resources
22 MeSH Terms
Combined MEK inhibition and BMP2 treatment promotes osteoblast differentiation and bone healing in Nf1Osx -/- mice.
de la Croix Ndong J, Stevens DM, Vignaux G, Uppuganti S, Perrien DS, Yang X, Nyman JS, Harth E, Elefteriou F
(2015) J Bone Miner Res 30: 55-63
MeSH Terms: Animals, Bone Morphogenetic Protein 2, Bone Regeneration, Cell Differentiation, Disease Models, Animal, Drug Delivery Systems, Humans, MAP Kinase Kinase Kinases, Mesenchymal Stem Cells, Mice, Mice, Knockout, Nanoparticles, Neurofibromatosis 1, Neurofibromin 1, Protein Kinase Inhibitors, Pseudarthrosis, Pyridones, Pyrimidinones
Added July 28, 2014
2 Communities
7 Members
0 Resources
18 MeSH Terms
Asfotase-α improves bone growth, mineralization and strength in mouse models of neurofibromatosis type-1.
de la Croix Ndong J, Makowski AJ, Uppuganti S, Vignaux G, Ono K, Perrien DS, Joubert S, Baglio SR, Granchi D, Stevenson DA, Rios JJ, Nyman JS, Elefteriou F
(2014) Nat Med 20: 904-10
MeSH Terms: Adolescent, Alkaline Phosphatase, Animals, Bone Development, Bone Diseases, Developmental, Bone Morphogenetic Protein 2, Calcification, Physiologic, Cells, Cultured, Child, Child, Preschool, Collagen Type I, Collagen Type I, alpha 1 Chain, Collagen Type II, Diphosphates, Disease Models, Animal, Durapatite, Humans, Immunoglobulin G, Infant, Mice, Mice, Inbred C57BL, Mice, Knockout, Mitogen-Activated Protein Kinases, Neurofibromatosis 1, Neurofibromin 1, Osteoblasts, Osteogenesis, Phosphate Transport Proteins, Phosphoric Diester Hydrolases, Pyrophosphatases, Recombinant Fusion Proteins, Sp7 Transcription Factor, Transcription Factors
Added July 28, 2014
2 Communities
4 Members
0 Resources
33 MeSH Terms
Neurofibromin inactivation impairs osteocyte development in Nf1Prx1 and Nf1Col1 mouse models.
Kühnisch J, Seto J, Lange C, Stumpp S, Kobus K, Grohmann J, Elefteriou F, Fratzl P, Mundlos S, Kolanczyk M
(2014) Bone 66: 155-62
MeSH Terms: Animals, Calcification, Physiologic, Cell Shape, Cell Survival, Energy Metabolism, Extracellular Matrix, Gene Expression Regulation, Humerus, Mice, Mice, Mutant Strains, Models, Animal, Neurofibromin 1, Osteocytes, Stress, Mechanical, Transcription, Genetic
Added January 22, 2015
0 Communities
1 Members
0 Resources
15 MeSH Terms
Multiscale, converging defects of macro-porosity, microstructure and matrix mineralization impact long bone fragility in NF1.
Kühnisch J, Seto J, Lange C, Schrof S, Stumpp S, Kobus K, Grohmann J, Kossler N, Varga P, Osswald M, Emmerich D, Tinschert S, Thielemann F, Duda G, Seifert W, El Khassawna T, Stevenson DA, Elefteriou F, Kornak U, Raum K, Fratzl P, Mundlos S, Kolanczyk M
(2014) PLoS One 9: e86115
MeSH Terms: Animals, Biomechanical Phenomena, Blood Vessels, Bone Density, Bone Matrix, Bone and Bones, Calcification, Physiologic, Collagen, Diaphyses, Homeodomain Proteins, Mice, Mice, Knockout, Neurofibromatosis 1, Neurofibromin 1, Osteocytes, Porosity, Tibia
Added March 20, 2014
0 Communities
1 Members
0 Resources
17 MeSH Terms
The ras-GTPase activity of neurofibromin restrains ERK-dependent FGFR signaling during endochondral bone formation.
Ono K, Karolak MR, Ndong Jde L, Wang W, Yang X, Elefteriou F
(2013) Hum Mol Genet 22: 3048-62
MeSH Terms: Animals, Apoptosis, Cell Proliferation, Chondrocytes, Chondrogenesis, Extracellular Signal-Regulated MAP Kinases, Gene Expression, Growth Plate, Mice, Knockout, Neurofibromin 1, Osteogenesis, Receptors, Fibroblast Growth Factor, Signal Transduction
Added November 14, 2013
0 Communities
3 Members
0 Resources
13 MeSH Terms
Zebrafish neurofibromatosis type 1 genes have redundant functions in tumorigenesis and embryonic development.
Shin J, Padmanabhan A, de Groh ED, Lee JS, Haidar S, Dahlberg S, Guo F, He S, Wolman MA, Granato M, Lawson ND, Wolfe SA, Kim SH, Solnica-Krezel L, Kanki JP, Ligon KL, Epstein JA, Look AT
(2012) Dis Model Mech 5: 881-94
MeSH Terms: Amino Acid Sequence, Animals, Base Sequence, Cell Proliferation, Cell Transformation, Neoplastic, Embryonic Development, Genes, Neurofibromatosis 1, Hyperplasia, Larva, Learning, Melanophores, Molecular Sequence Data, Motor Activity, Mutation, Myelin Sheath, Neurofibromatosis 1, Neurofibromin 1, Oligodendroglia, Schwann Cells, Signal Transduction, Stem Cells, Tumor Suppressor Protein p53, Up-Regulation, Zebrafish, Zebrafish Proteins, ras Proteins
Added September 24, 2013
0 Communities
1 Members
0 Resources
26 MeSH Terms
Mice lacking Nf1 in osteochondroprogenitor cells display skeletal dysplasia similar to patients with neurofibromatosis type I.
Wang W, Nyman JS, Ono K, Stevenson DA, Yang X, Elefteriou F
(2011) Hum Mol Genet 20: 3910-24
MeSH Terms: Animals, Bone Diseases, Developmental, Bone Remodeling, Bone and Bones, Chondrocytes, Collagen Type II, Enzyme Activation, Extracellular Signal-Regulated MAP Kinases, Female, Intervertebral Disc, Lovastatin, Mice, Mice, Knockout, Neurofibromatosis 1, Neurofibromin 1, Osteoblasts, Osteocytes, Osteogenesis, Phenotype, Porosity, Promoter Regions, Genetic, Recombination, Genetic, Stem Cells, ras Proteins
Added November 14, 2013
1 Communities
3 Members
0 Resources
24 MeSH Terms
Local low-dose lovastatin delivery improves the bone-healing defect caused by Nf1 loss of function in osteoblasts.
Wang W, Nyman JS, Moss HE, Gutierrez G, Mundy GR, Yang X, Elefteriou F
(2010) J Bone Miner Res 25: 1658-67
MeSH Terms: Animals, Bone Density, Bony Callus, Fracture Healing, Lovastatin, Male, Mice, Neurofibromatosis 1, Neurofibromin 1, Osteoblasts, Tibial Fractures, X-Ray Microtomography
Added November 14, 2013
0 Communities
2 Members
0 Resources
12 MeSH Terms
Signals from both sides: Control of cardiac development by the endocardium and epicardium.
Smith TK, Bader DM
(2007) Semin Cell Dev Biol 18: 84-9
MeSH Terms: Animals, Chemokine CXCL12, Chemokines, CXC, Endocardium, Endothelins, Feedback, Physiological, Fibroblast Growth Factors, Heart, Humans, Morphogenesis, Neuregulin-1, Neurofibromin 1, Pericardium, Signal Transduction, Tretinoin
Added September 28, 2015
1 Communities
1 Members
0 Resources
15 MeSH Terms