EPO synthesis induced by HIF-PHD inhibition is dependent on myofibroblast transdifferentiation and colocalizes with non-injured nephron segments in murine kidney fibrosis.
Kobayashi H, Davidoff O, Pujari-Palmer S, Drevin M, Haase VH
(2022) Acta Physiol (Oxf) 235
: e13826MeSH Terms: Animals, Cell Transdifferentiation, Erythropoietin, Fibrosis, Hypoxia-Inducible Factor-Proline Dioxygenases, Kidney, Mice, Mice, Knockout, Myofibroblasts, Nephrons, Prolyl Hydroxylases, Renal Insufficiency, ChronicAdded May 3, 2022
12 MeSH Terms
Disruption of mitochondrial complex III in cap mesenchyme but not in ureteric progenitors results in defective nephrogenesis associated with amino acid deficiency.
Guan N, Kobayashi H, Ishii K, Davidoff O, Sha F, Ikizler TA, Hao CM, Chandel NS, Haase VH
(2022) Kidney Int 102
: 108-120MeSH Terms: Amino Acids, Cell Differentiation, Electron Transport Complex III, Female, Humans, Kidney, Mesoderm, Nephrons, Organogenesis, Podocytes, Pregnancy, UreterAdded March 30, 2022
12 MeSH Terms
Direct reprogramming to human nephron progenitor-like cells using inducible piggyBac transposon expression of SNAI2-EYA1-SIX1.
Vanslambrouck JM, Woodard LE, Suhaimi N, Williams FM, Howden SE, Wilson SB, Lonsdale A, Er PX, Li J, Maksimovic J, Oshlack A, Wilson MH, Little MH
(2019) Kidney Int 95
: 1153-1166MeSH Terms: Cells, Cultured, Cellular Reprogramming, DNA Transposable Elements, Gene Transfer Techniques, Genetic Engineering, Homeodomain Proteins, Humans, Intracellular Signaling Peptides and Proteins, Nephrons, Nuclear Proteins, Primary Cell Culture, Protein Tyrosine Phosphatases, Regeneration, Snail Family Transcription FactorsAdded March 28, 2019
14 MeSH Terms
Does Secretory Clearance Follow Glomerular Filtration Rate in Chronic Kidney Diseases? Reconsidering the Intact Nephron Hypothesis.
Chapron A, Shen DD, Kestenbaum BR, Robinson-Cohen C, Himmelfarb J, Yeung CK
(2017) Clin Transl Sci 10
: 395-403MeSH Terms: Glomerular Filtration Rate, Humans, Models, Biological, Nephrons, Pharmaceutical Preparations, Renal Insufficiency, ChronicAdded September 19, 2017
6 MeSH Terms
Integrated compensatory network is activated in the absence of NCC phosphorylation.
Grimm PR, Lazo-Fernandez Y, Delpire E, Wall SM, Dorsey SG, Weinman EJ, Coleman R, Wade JB, Welling PA
(2015) J Clin Invest 125
: 2136-50MeSH Terms: Amiloride, Ammonia, Animals, Biological Transport, Blood Pressure, Carbonic Anhydrases, Chlorides, Disease Models, Animal, Enzyme Activation, Epithelial Sodium Channels, Gene Expression Profiling, Gene Regulatory Networks, Gitelman Syndrome, Ketoglutaric Acids, Kidney Glomerulus, Male, Mice, Mice, Knockout, Natriuresis, Nephrons, Paracrine Communication, Phosphorylation, Protein Processing, Post-Translational, Protein Serine-Threonine Kinases, Receptors, Notch, Receptors, Purinergic P2, Renal Reabsorption, Signal Transduction, Sodium Chloride, Sodium-Potassium-Chloride Symporters, Solute Carrier Family 12, Member 3Added May 3, 2017
31 MeSH Terms
Percutaneous cryoablation for recurrent low grade renal cell carcinoma after failed nephron-sparing surgery.
Morgan MA, Roberts NR, Pino LA, Trabulsi EJ, Brown DB, Gomella LG, Lallas CD
(2013) Can J Urol 20
: 6933-7MeSH Terms: Administration, Cutaneous, Aged, Aged, 80 and over, Carcinoma, Renal Cell, Cryosurgery, Female, Follow-Up Studies, Humans, Incidence, Kidney Neoplasms, Male, Middle Aged, Neoplasm Grading, Neoplasm Recurrence, Local, Nephrectomy, Nephrons, Organ Sparing Treatments, Tomography, X-Ray Computed, Treatment Failure, Treatment OutcomeAdded March 5, 2014
20 MeSH Terms
Aberrant activation, nuclear localization, and phosphorylation of Yes-associated protein-1 in the embryonic kidney and Wilms tumor.
Murphy AJ, Pierce J, de Caestecker C, Libes J, Neblett D, de Caestecker M, Perantoni AO, Tanigawa S, Anderson JR, Dome JS, Das A, Carroll TJ, Lovvorn HN
(2014) Pediatr Blood Cancer 61
: 198-205MeSH Terms: Adaptor Proteins, Signal Transducing, Animals, Blotting, Western, Cell Cycle Proteins, Cell Nucleus, Cell Proliferation, Cells, Cultured, Child, Preschool, Embryo, Mammalian, Female, Gene Expression Regulation, Developmental, HeLa Cells, Humans, Immunoenzyme Techniques, Kidney, Kidney Neoplasms, Male, Mice, Mice, Knockout, Nephrons, Phosphoproteins, Phosphorylation, Protein Transport, Stem Cells, Subcellular Fractions, Transcription Factors, Wilms Tumor, YAP-Signaling ProteinsAdded January 10, 2014
28 MeSH Terms
Maturational regression of glomeruli determines the nephron population in normal mice.
Zhong J, Perrien DS, Yang HC, Kon V, Fogo AB, Ichikawa I, Ma J
(2012) Pediatr Res 72
: 241-8MeSH Terms: Angiopoietin-2, Animals, Immunohistochemistry, Kidney Glomerulus, Mice, Nephrons, Thrombospondin 1Added April 25, 2013
7 MeSH Terms
SIX2 and CITED1, markers of nephronic progenitor self-renewal, remain active in primitive elements of Wilms' tumor.
Murphy AJ, Pierce J, de Caestecker C, Taylor C, Anderson JR, Perantoni AO, de Caestecker MP, Lovvorn HN
(2012) J Pediatr Surg 47
: 1239-49MeSH Terms: Apoptosis Regulatory Proteins, Biomarkers, Tumor, Blotting, Western, Cell Nucleus, Cytosol, Gene Expression Regulation, Neoplastic, Homeodomain Proteins, Humans, Immunoenzyme Techniques, Kidney, Kidney Neoplasms, Microscopy, Fluorescence, Neoplasm Proteins, Neoplastic Stem Cells, Nephrons, Nerve Tissue Proteins, Nuclear Proteins, Prognosis, RNA, Messenger, RNA, Neoplasm, Reverse Transcriptase Polymerase Chain Reaction, Single-Blind Method, Trans-Activators, Transcription Factors, Wilms TumorAdded January 28, 2014
25 MeSH Terms
FGF9 and FGF20 maintain the stemness of nephron progenitors in mice and man.
Barak H, Huh SH, Chen S, Jeanpierre C, Martinovic J, Parisot M, Bole-Feysot C, Nitschké P, Salomon R, Antignac C, Ornitz DM, Kopan R
(2012) Dev Cell 22
: 1191-207MeSH Terms: Animals, Bone Morphogenetic Protein 7, Cell Differentiation, Congenital Abnormalities, Female, Fibroblast Growth Factor 9, Fibroblast Growth Factors, Humans, Kidney, Kidney Diseases, Male, Mesenchymal Stem Cells, Mice, Mutation, Nephrons, Organ Culture Techniques, Stem Cell Niche, Wnt Signaling PathwayAdded June 27, 2012
18 MeSH Terms