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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 35

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Collagen IV dysfunction in glomerular basement membrane diseases. I. Discovery of a COL4A3 variant in familial Goodpasture's and Alport diseases.
Pokidysheva EN, Seeger H, Pedchenko V, Chetyrkin S, Bergmann C, Abrahamson D, Cui ZW, Delpire E, Fervenza FC, Fidler AL, Fogo AB, Gaspert A, Grohmann M, Gross O, Haddad G, Harris RC, Kashtan C, Kitching AR, Lorenzen JM, McAdoo S, Pusey CD, Segelmark M, Simmons A, Voziyan PA, Wagner T, Wüthrich RP, Zhao MH, Boudko SP, Kistler AD, Hudson BG
(2021) J Biol Chem 296: 100590
MeSH Terms: Animals, Anti-Glomerular Basement Membrane Disease, Collagen Type IV, Mice, Models, Molecular, Mutation, Nephritis, Hereditary, Protein Multimerization, Protein Structure, Quaternary, Signal Transduction
Added September 3, 2021
1 Communities
0 Members
0 Resources
MeSH Terms
Two Specific Sulfatide Species Are Dysregulated during Renal Development in a Mouse Model of Alport Syndrome.
Gessel MM, Spraggins JM, Voziyan PA, Abrahamson DR, Caprioli RM, Hudson BG
(2019) Lipids 54: 411-418
MeSH Terms: Animals, Disease Models, Animal, Kidney Tubules, Lipid Metabolism, Mice, Nephritis, Hereditary, Sulfoglycosphingolipids
Added January 22, 2020
0 Communities
2 Members
0 Resources
7 MeSH Terms
Anti-microRNA-21 oligonucleotides prevent Alport nephropathy progression by stimulating metabolic pathways.
Gomez IG, MacKenna DA, Johnson BG, Kaimal V, Roach AM, Ren S, Nakagawa N, Xin C, Newitt R, Pandya S, Xia TH, Liu X, Borza DB, Grafals M, Shankland SJ, Himmelfarb J, Portilla D, Liu S, Chau BN, Duffield JS
(2015) J Clin Invest 125: 141-56
MeSH Terms: Animals, Autoantigens, Collagen Type IV, Disease Progression, Fibrosis, Kidney, Metabolic Networks and Pathways, Mice, 129 Strain, MicroRNAs, Nephritis, Hereditary, Oligoribonucleotides, Antisense, Reactive Oxygen Species, Transcriptome, Up-Regulation
Added December 2, 2016
1 Communities
1 Members
0 Resources
14 MeSH Terms
Quaternary epitopes of α345(IV) collagen initiate Alport post-transplant anti-GBM nephritis.
Olaru F, Luo W, Wang XP, Ge L, Hertz JM, Kashtan CE, Sado Y, Segal Y, Hudson BG, Borza DB
(2013) J Am Soc Nephrol 24: 889-95
MeSH Terms: Animals, Anti-Glomerular Basement Membrane Disease, Autoantigens, Basement Membrane, Cattle, Collagen Type IV, Epitope Mapping, Haplorhini, Humans, Immunoglobulin G, Isoantibodies, Kidney Glomerulus, Kidney Transplantation, Mice, Mice, Transgenic, Nephritis, Hereditary, Postoperative Complications, Protein Interaction Domains and Motifs, Protein Structure, Quaternary, Transplantation, Homologous
Added August 21, 2013
1 Communities
2 Members
0 Resources
20 MeSH Terms
Upregulated expression of integrin α1 in mesangial cells and integrin α3 and vimentin in podocytes of Col4a3-null (Alport) mice.
Steenhard BM, Vanacore R, Friedman D, Zelenchuk A, Stroganova L, Isom K, St John PL, Hudson BG, Abrahamson DR
(2012) PLoS One 7: e50745
MeSH Terms: Animals, Autoantigens, Collagen Type IV, Disease Models, Animal, Glomerular Basement Membrane, Integrin alpha1, Integrin alpha3, Mesangial Cells, Mice, Mice, Knockout, Nephritis, Hereditary, Podocytes, Up-Regulation, Vimentin
Added August 21, 2013
1 Communities
2 Members
0 Resources
14 MeSH Terms
Mapping structural landmarks, ligand binding sites, and missense mutations to the collagen IV heterotrimers predicts major functional domains, novel interactions, and variation in phenotypes in inherited diseases affecting basement membranes.
Parkin JD, San Antonio JD, Pedchenko V, Hudson B, Jensen ST, Savige J
(2011) Hum Mutat 32: 127-43
MeSH Terms: Amino Acid Sequence, Basement Membrane, Collagen Type IV, Humans, Ligands, Molecular Sequence Data, Mutation, Nephritis, Hereditary, Protein Interaction Domains and Motifs, Protein Interaction Mapping, Protein Structure, Tertiary
Added August 27, 2013
1 Communities
2 Members
0 Resources
11 MeSH Terms
Alport alloantibodies but not Goodpasture autoantibodies induce murine glomerulonephritis: protection by quinary crosslinks locking cryptic α3(IV) collagen autoepitopes in vivo.
Luo W, Wang XP, Kashtan CE, Borza DB
(2010) J Immunol 185: 3520-8
MeSH Terms: Animals, Anti-Glomerular Basement Membrane Disease, Autoantibodies, Autoantigens, Binding Sites, Antibody, Collagen Type IV, Cross Reactions, Epitopes, Glomerulonephritis, Humans, Isoantibodies, Mice, Mice, Inbred C57BL, Mice, Knockout, Nephritis, Hereditary, Protein Structure, Tertiary
Added August 21, 2013
0 Communities
1 Members
0 Resources
16 MeSH Terms
Molecular architecture of the Goodpasture autoantigen in anti-GBM nephritis.
Pedchenko V, Bondar O, Fogo AB, Vanacore R, Voziyan P, Kitching AR, Wieslander J, Kashtan C, Borza DB, Neilson EG, Wilson CB, Hudson BG
(2010) N Engl J Med 363: 343-54
MeSH Terms: Adult, Aged, Aged, 80 and over, Anti-Glomerular Basement Membrane Disease, Antibodies, Autoantibodies, Autoantigens, Binding Sites, Antibody, Collagen Type IV, Enzyme-Linked Immunosorbent Assay, Epitope Mapping, Epitopes, Female, Glomerular Basement Membrane, Humans, Isoantibodies, Kidney Glomerulus, Kidney Transplantation, Male, Middle Aged, Nephritis, Nephritis, Hereditary, Postoperative Complications, Protein Conformation, Protein Isoforms, Retrospective Studies, Young Adult
Added December 10, 2013
1 Communities
6 Members
1 Resources
27 MeSH Terms
Cellular origins of type IV collagen networks in developing glomeruli.
Abrahamson DR, Hudson BG, Stroganova L, Borza DB, St John PL
(2009) J Am Soc Nephrol 20: 1471-9
MeSH Terms: Animals, Autoantigens, Collagen Type IV, Disease Models, Animal, Endothelium, Kidney Glomerulus, Mesangial Cells, Mice, Mice, Knockout, Nephritis, Hereditary, Podocytes
Added December 10, 2013
1 Communities
2 Members
0 Resources
11 MeSH Terms
Stem cell therapy for Alport syndrome: the hope beyond the hype.
Gross O, Borza DB, Anders HJ, Licht C, Weber M, Segerer S, Torra R, Gubler MC, Heidet L, Harvey S, Cosgrove D, Lees G, Kashtan C, Gregory M, Savige J, Ding J, Thorner P, Abrahamson DR, Antignac C, Tryggvason K, Hudson B, Miner JH
(2009) Nephrol Dial Transplant 24: 731-4
MeSH Terms: Animals, Autoantigens, Collagen Type IV, Humans, Mice, Nephritis, Hereditary, Renal Insufficiency, Stem Cell Transplantation
Added August 21, 2013
1 Communities
2 Members
0 Resources
8 MeSH Terms