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Results: 1 to 10 of 10

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Preventing the autophagic survival response by inhibition of calpain enhances the cytotoxic activity of bortezomib in vitro and in vivo.
Escalante AM, McGrath RT, Karolak MR, Dorr RT, Lynch RM, Landowski TH
(2013) Cancer Chemother Pharmacol 71: 1567-76
MeSH Terms: Animals, Antineoplastic Agents, Apoptosis, Autophagy, Boronic Acids, Bortezomib, Calpain, Cell Line, Tumor, Cell Survival, Drug Synergism, HIV Protease Inhibitors, Humans, Mice, Mice, SCID, Multiple Myeloma, Nelfinavir, Pyrazines, RNA, Small Interfering, Xenograft Model Antitumor Assays
Added August 19, 2013
0 Communities
1 Members
0 Resources
19 MeSH Terms
Mitochondrial genomics and CD4 T-cell count recovery after antiretroviral therapy initiation in AIDS clinical trials group study 384.
Grady BJ, Samuels DC, Robbins GK, Selph D, Canter JA, Pollard RB, Haas DW, Shafer R, Kalams SA, Murdock DG, Ritchie MD, Hulgan T, ACTG 384 and DACS 250 Study Teams
(2011) J Acquir Immune Defic Syndr 58: 363-70
MeSH Terms: Acquired Immunodeficiency Syndrome, Adolescent, Adult, Aged, Alkynes, Anti-HIV Agents, Base Sequence, Benzoxazines, CD4 Lymphocyte Count, CD4-Positive T-Lymphocytes, Cyclopropanes, Drug Therapy, Combination, Female, Genome, Mitochondrial, Haplotypes, Humans, Male, Middle Aged, Molecular Sequence Data, Nelfinavir, Polymorphism, Single Nucleotide, RNA, Viral, Treatment Outcome, Viral Load, Young Adult
Added December 12, 2013
1 Communities
3 Members
0 Resources
25 MeSH Terms
Pharmacogenetics of long-term responses to antiretroviral regimens containing Efavirenz and/or Nelfinavir: an Adult Aids Clinical Trials Group Study.
Haas DW, Smeaton LM, Shafer RW, Robbins GK, Morse GD, Labbe L, Wilkinson GR, Clifford DB, D'Aquila RT, De Gruttola V, Pollard RB, Merigan TC, Hirsch MS, George AL, Donahue JP, Kim RB
(2005) J Infect Dis 192: 1931-42
MeSH Terms: ATP Binding Cassette Transporter, Subfamily B, Member 1, Adult, Alkynes, Anti-HIV Agents, Benzoxazines, Cyclopropanes, Cytochrome P-450 Enzyme System, Drug Resistance, Viral, Drug Therapy, Combination, Female, HIV Infections, Humans, Male, Middle Aged, Nelfinavir, Oxazines, Pharmacogenetics, Polymorphism, Genetic, Reverse Transcriptase Inhibitors, Time Factors, Treatment Outcome
Added March 13, 2015
0 Communities
1 Members
0 Resources
21 MeSH Terms
The pharmacokinetics of nelfinavir and M8 during pregnancy and post partum.
van Heeswijk RP, Khaliq Y, Gallicano KD, Bourbeau M, Seguin I, Phillips EJ, Cameron DW
(2004) Clin Pharmacol Ther 76: 588-97
MeSH Terms: Adult, Anti-HIV Agents, Chromatography, High Pressure Liquid, Female, Fetal Blood, Half-Life, Humans, Longitudinal Studies, Mass Spectrometry, Nelfinavir, Postpartum Period, Pregnancy
Added March 30, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
Diarrhea-associated HIV-1 APIs potentiate muscarinic activation of Cl- secretion by T84 cells via prolongation of cytosolic Ca2+ signaling.
Rufo PA, Lin PW, Andrade A, Jiang L, Rameh L, Flexner C, Alper SL, Lencer WI
(2004) Am J Physiol Cell Physiol 286: C998-C1008
MeSH Terms: Adult, Aspartic Acid Endopeptidases, Calcium Signaling, Carbachol, Cell Line, Cell Membrane, Chlorides, Cytosol, Diarrhea, Drug Synergism, Electric Conductivity, HIV Infections, HIV-1, Humans, Intestinal Mucosa, Intracellular Membranes, Middle Aged, Muscarinic Agonists, Nelfinavir, Protease Inhibitors, Time Factors
Added December 10, 2018
0 Communities
1 Members
0 Resources
21 MeSH Terms
Treatment with indinavir, efavirenz, and adefovir after failure of nelfinavir therapy.
Saah AJ, Haas DW, DiNubile MJ, Chen J, Holder DJ, Rhodes RR, Shivaprakash M, Bakshi KK, Danovich RM, Graham DJ, Condra JH
(2003) J Infect Dis 187: 1157-62
MeSH Terms: Adenine, Adult, Alkynes, Anti-HIV Agents, Benzoxazines, Cyclopropanes, Drug Resistance, Viral, Female, HIV, HIV Infections, HIV Protease Inhibitors, Humans, Indinavir, Male, Middle Aged, Nelfinavir, Organophosphonates, Oxazines, Treatment Failure
Added March 13, 2015
0 Communities
1 Members
0 Resources
19 MeSH Terms
Effects of nelfinavir and its M8 metabolite on lymphocyte P-glycoprotein activity during antiretroviral therapy.
Donahue JP, Dowdy D, Ratnam KK, Hulgan T, Price J, Unutmaz D, Nicotera J, Raffanti S, Becker M, Haas DW
(2003) Clin Pharmacol Ther 73: 78-86
MeSH Terms: ATP Binding Cassette Transporter, Subfamily B, Member 1, Adult, CD4-Positive T-Lymphocytes, CD8-Positive T-Lymphocytes, Female, HIV Protease Inhibitors, HIV Seropositivity, Humans, Male, Nelfinavir, T-Lymphocytes
Added December 10, 2013
0 Communities
2 Members
0 Resources
11 MeSH Terms
Evidence of a source of HIV type 1 within the central nervous system by ultraintensive sampling of cerebrospinal fluid and plasma.
Haas DW, Clough LA, Johnson BW, Harris VL, Spearman P, Wilkinson GR, Fletcher CV, Fiscus S, Raffanti S, Donlon R, McKinsey J, Nicotera J, Schmidt D, Shoup RE, Kates RE, Lloyd RM, Larder B
(2000) AIDS Res Hum Retroviruses 16: 1491-502
MeSH Terms: Adult, Anti-HIV Agents, Central Nervous System, Drug Resistance, Microbial, Genetic Variation, HIV Infections, HIV Protease Inhibitors, HIV-1, Humans, Lamivudine, Nelfinavir, RNA, Viral, Reverse Transcriptase Inhibitors, Stavudine, Time Factors
Added March 13, 2015
0 Communities
1 Members
0 Resources
15 MeSH Terms
Factors that predict incomplete virological response to protease inhibitor-based antiretroviral therapy.
Clough LA, D'Agata E, Raffanti S, Haas DW
(1999) Clin Infect Dis 29: 75-81; discussion 82-4
MeSH Terms: Adult, Anti-HIV Agents, Cohort Studies, Drug Therapy, Combination, Female, HIV Infections, HIV Protease Inhibitors, HIV-1, Humans, Indinavir, Male, Nelfinavir, Prognosis, Retrospective Studies, Ritonavir
Added March 13, 2015
0 Communities
1 Members
0 Resources
15 MeSH Terms
The drug transporter P-glycoprotein limits oral absorption and brain entry of HIV-1 protease inhibitors.
Kim RB, Fromm MF, Wandel C, Leake B, Wood AJ, Roden DM, Wilkinson GR
(1998) J Clin Invest 101: 289-94
MeSH Terms: ATP Binding Cassette Transporter, Subfamily B, Member 1, Animals, Caco-2 Cells, HIV Protease, HIV Protease Inhibitors, Humans, Indinavir, Intestinal Absorption, Male, Mice, Nelfinavir, Saquinavir
Added March 27, 2014
0 Communities
1 Members
0 Resources
12 MeSH Terms