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Results: 1 to 10 of 34

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Activation of Nrf2 attenuates delayed gastric emptying in obesity induced diabetic (T2DM) female mice.
Sampath C, Sprouse JC, Freeman ML, Gangula PR
(2019) Free Radic Biol Med 135: 132-143
MeSH Terms: Acrolein, Animals, Antioxidants, Diabetes Complications, Diabetes Mellitus, Type 2, Diet, High-Fat, Gastric Emptying, Gastroparesis, Humans, MAP Kinase Signaling System, Mice, Muscle Relaxation, NF-E2-Related Factor 2, Nitric Oxide Synthase Type I, Obesity, Stomach, p38 Mitogen-Activated Protein Kinases
Added March 3, 2020
0 Communities
1 Members
0 Resources
17 MeSH Terms
An Integrated, High-Throughput Strategy for Multiomic Systems Level Analysis.
Gutierrez DB, Gant-Branum RL, Romer CE, Farrow MA, Allen JL, Dahal N, Nei YW, Codreanu SG, Jordan AT, Palmer LD, Sherrod SD, McLean JA, Skaar EP, Norris JL, Caprioli RM
(2018) J Proteome Res 17: 3396-3408
MeSH Terms: Gene Expression Profiling, Genomics, HL-60 Cells, Humans, Metabolomics, NF-E2-Related Factor 2, NF-kappa B, Proteomics, Signal Transduction, Systems Biology, Zinc
Added August 27, 2018
1 Communities
3 Members
0 Resources
11 MeSH Terms
Suppressed ubiquitination of Nrf2 by p47 contributes to Nrf2 activation.
Ha Kim K, Sadikot RT, Yeon Lee J, Jeong HS, Oh YK, Blackwell TS, Joo M
(2017) Free Radic Biol Med 113: 48-58
MeSH Terms: Animals, Disease Models, Animal, HEK293 Cells, Humans, Kelch-Like ECH-Associated Protein 1, Lipopolysaccharides, Mice, NADPH Oxidases, NF-E2-Related Factor 2, Pneumonia, RAW 264.7 Cells, Reactive Oxygen Species, Signal Transduction, Ubiquitination
Added March 21, 2018
0 Communities
1 Members
0 Resources
14 MeSH Terms
Loss of Nrf2 promotes alveolar type 2 cell loss in irradiated, fibrotic lung.
Traver G, Mont S, Gius D, Lawson WE, Ding GX, Sekhar KR, Freeman ML
(2017) Free Radic Biol Med 112: 578-586
MeSH Terms: Animals, Cell Proliferation, Cell Survival, Epithelial Cells, Gene Expression Regulation, Hematopoietic Stem Cell Mobilization, Lung, Male, Mice, Mice, Inbred C57BL, Mice, Knockout, Myofibroblasts, NF-E2-Related Factor 2, Phosphoproteins, Pulmonary Fibrosis, Respiratory Mucosa, Signal Transduction, Stem Cells, Thorax, Trans-Activators, X-Rays
Added April 12, 2021
0 Communities
0 Members
0 Resources
MeSH Terms
NADPH oxidase 4 deficiency increases tubular cell death during acute ischemic reperfusion injury.
Nlandu-Khodo S, Dissard R, Hasler U, Schäfer M, Pircher H, Jansen-Durr P, Krause KH, Martin PY, de Seigneux S
(2016) Sci Rep 6: 38598
MeSH Terms: Animals, Apoptosis, Cell Death, Creatinine, Disease Models, Animal, Gene Expression, Gene Expression Regulation, Genetic Predisposition to Disease, Glutathione, Kelch-Like ECH-Associated Protein 1, Kidney Diseases, Kidney Tubules, Mice, Mice, Knockout, Mitochondria, NADPH Oxidase 4, NF-E2-Related Factor 2, Oxidation-Reduction, Proto-Oncogene Proteins c-bcl-2, Reperfusion Injury
Added December 26, 2018
0 Communities
1 Members
0 Resources
MeSH Terms
Comprehensive Molecular Characterization of Papillary Renal-Cell Carcinoma.
Cancer Genome Atlas Research Network, Linehan WM, Spellman PT, Ricketts CJ, Creighton CJ, Fei SS, Davis C, Wheeler DA, Murray BA, Schmidt L, Vocke CD, Peto M, Al Mamun AA, Shinbrot E, Sethi A, Brooks S, Rathmell WK, Brooks AN, Hoadley KA, Robertson AG, Brooks D, Bowlby R, Sadeghi S, Shen H, Weisenberger DJ, Bootwalla M, Baylin SB, Laird PW, Cherniack AD, Saksena G, Haake S, Li J, Liang H, Lu Y, Mills GB, Akbani R, Leiserson MD, Raphael BJ, Anur P, Bottaro D, Albiges L, Barnabas N, Choueiri TK, Czerniak B, Godwin AK, Hakimi AA, Ho TH, Hsieh J, Ittmann M, Kim WY, Krishnan B, Merino MJ, Mills Shaw KR, Reuter VE, Reznik E, Shelley CS, Shuch B, Signoretti S, Srinivasan R, Tamboli P, Thomas G, Tickoo S, Burnett K, Crain D, Gardner J, Lau K, Mallery D, Morris S, Paulauskis JD, Penny RJ, Shelton C, Shelton WT, Sherman M, Thompson E, Yena P, Avedon MT, Bowen J, Gastier-Foster JM, Gerken M, Leraas KM, Lichtenberg TM, Ramirez NC, Santos T, Wise L, Zmuda E, Demchok JA, Felau I, Hutter CM, Sheth M, Sofia HJ, Tarnuzzer R, Wang Z, Yang L, Zenklusen JC, Zhang J, Ayala B, Baboud J, Chudamani S, Liu J, Lolla L, Naresh R, Pihl T, Sun Q, Wan Y, Wu Y, Ally A, Balasundaram M, Balu S, Beroukhim R, Bodenheimer T, Buhay C, Butterfield YS, Carlsen R, Carter SL, Chao H, Chuah E, Clarke A, Covington KR, Dahdouli M, Dewal N, Dhalla N, Doddapaneni HV, Drummond JA, Gabriel SB, Gibbs RA, Guin R, Hale W, Hawes A, Hayes DN, Holt RA, Hoyle AP, Jefferys SR, Jones SJ, Jones CD, Kalra D, Kovar C, Lewis L, Li J, Ma Y, Marra MA, Mayo M, Meng S, Meyerson M, Mieczkowski PA, Moore RA, Morton D, Mose LE, Mungall AJ, Muzny D, Parker JS, Perou CM, Roach J, Schein JE, Schumacher SE, Shi Y, Simons JV, Sipahimalani P, Skelly T, Soloway MG, Sougnez C, Tam A, Tan D, Thiessen N, Veluvolu U, Wang M, Wilkerson MD, Wong T, Wu J, Xi L, Zhou J, Bedford J, Chen F, Fu Y, Gerstein M, Haussler D, Kasaian K, Lai P, Ling S, Radenbaugh A, Van Den Berg D, Weinstein JN, Zhu J, Albert M, Alexopoulou I, Andersen JJ, Auman JT, Bartlett J, Bastacky S, Bergsten J, Blute ML, Boice L, Bollag RJ, Boyd J, Castle E, Chen YB, Cheville JC, Curley E, Davies B, DeVolk A, Dhir R, Dike L, Eckman J, Engel J, Harr J, Hrebinko R, Huang M, Huelsenbeck-Dill L, Iacocca M, Jacobs B, Lobis M, Maranchie JK, McMeekin S, Myers J, Nelson J, Parfitt J, Parwani A, Petrelli N, Rabeno B, Roy S, Salner AL, Slaton J, Stanton M, Thompson RH, Thorne L, Tucker K, Weinberger PM, Winemiller C, Zach LA, Zuna R
(2016) N Engl J Med 374: 135-45
MeSH Terms: Carcinoma, Papillary, CpG Islands, DNA Methylation, Humans, Kidney Neoplasms, MicroRNAs, Mutation, NF-E2-Related Factor 2, Phenotype, Proto-Oncogene Proteins c-met, RNA, Messenger, RNA, Neoplasm, Sequence Analysis, RNA, Signal Transduction
Added August 8, 2016
1 Communities
2 Members
0 Resources
14 MeSH Terms
Heme oxygenase-1 dysregulates macrophage polarization and the immune response to Helicobacter pylori.
Gobert AP, Verriere T, Asim M, Barry DP, Piazuelo MB, de Sablet T, Delgado AG, Bravo LE, Correa P, Peek RM, Chaturvedi R, Wilson KT
(2014) J Immunol 193: 3013-22
MeSH Terms: Animals, Antigens, Bacterial, Bacterial Proteins, Cell Line, Enzyme Inhibitors, Gastric Mucosa, Gastritis, Helicobacter Infections, Helicobacter pylori, Heme Oxygenase-1, Humans, Imidazoles, Inflammation, Interleukin-10, MAP Kinase Signaling System, Macrophages, Membrane Proteins, Mice, Mice, Inbred C57BL, Mice, Knockout, NF-E2-Related Factor 2, Nitric Oxide Synthase Type II, Phagocytosis, Phosphorylation, Pyridines, Signal Transduction, Stomach, Th1 Cells, Th17 Cells, p38 Mitogen-Activated Protein Kinases
Added January 20, 2015
0 Communities
3 Members
0 Resources
30 MeSH Terms
LKB1 Loss induces characteristic patterns of gene expression in human tumors associated with NRF2 activation and attenuation of PI3K-AKT.
Kaufman JM, Amann JM, Park K, Arasada RR, Li H, Shyr Y, Carbone DP
(2014) J Thorac Oncol 9: 794-804
MeSH Terms: AMP-Activated Protein Kinases, Adaptor Proteins, Signal Transducing, Adenocarcinoma, Animals, Ataxia Telangiectasia Mutated Proteins, Carcinoma, Non-Small-Cell Lung, Cell Line, Tumor, Cytoskeletal Proteins, ErbB Receptors, GA-Binding Protein Transcription Factor, Humans, Intracellular Signaling Peptides and Proteins, Kelch-Like ECH-Associated Protein 1, Lung Neoplasms, Mice, Mitochondria, Multigene Family, Mutation, NF-E2-Related Factor 2, Phosphatidylinositol 3-Kinase, Phosphorylation, Protein-Serine-Threonine Kinases, Proto-Oncogene Proteins, Proto-Oncogene Proteins c-akt, Proto-Oncogene Proteins p21(ras), RNA, Messenger, Signal Transduction, Transcriptome, Tumor Suppressor Protein p53, ras Proteins
Added February 19, 2015
0 Communities
1 Members
0 Resources
30 MeSH Terms
Nrf1 and Nrf2 transcription factors regulate androgen receptor transactivation in prostate cancer cells.
Schultz MA, Hagan SS, Datta A, Zhang Y, Freeman ML, Sikka SC, Abdel-Mageed AB, Mondal D
(2014) PLoS One 9: e87204
MeSH Terms: Analysis of Variance, Cell Line, Tumor, Chromatin Immunoprecipitation, DNA Primers, Dihydrotestosterone, Electrophoretic Mobility Shift Assay, Humans, Immunoblotting, Luciferases, Male, NF-E2-Related Factor 2, Nuclear Respiratory Factor 1, Prostatic Neoplasms, Castration-Resistant, Real-Time Polymerase Chain Reaction, Receptors, Androgen, Transcriptional Activation
Added March 13, 2014
0 Communities
1 Members
0 Resources
16 MeSH Terms
Nrf2 is essential for the expression of lipocalin-prostaglandin D synthase induced by prostaglandin D2.
Kim KH, Sadikot RT, Xiao L, Christman JW, Freeman ML, Chan JY, Oh YK, Blackwell TS, Joo M
(2013) Free Radic Biol Med 65: 1134-1142
MeSH Terms: Amino Acid Sequence, Animals, Base Sequence, Binding Sites, Cell Line, Cyclooxygenase 2, Intramolecular Oxidoreductases, Lipocalins, Lipopolysaccharides, Lung, Macrophages, Mice, Mice, Inbred C57BL, Mice, Knockout, NF-E2-Related Factor 2, Neutrophil Infiltration, Neutrophils, Pneumonia, Promoter Regions, Genetic, Prostaglandin D2, Protein Binding, RNA Interference, RNA, Small Interfering, Sequence Analysis, DNA, Toll-Like Receptor 4
Added March 7, 2014
1 Communities
2 Members
0 Resources
25 MeSH Terms